What’s new for rosacea treatment?

Written by on July 19, 2019 in Acne Treatments, New Rosacea Treatments with 2 Comments

new rosacea treatments

If, like me, you see a published article titled `What’s new for rosacea treatment’ and get a small rush thinking there must be something new about to burst on to the market, then maybe you might share my disappointment. All regular readers of this web site will know the latest and greatest information about the world of rosacea research and treatments. Still, here is a summary of recent developments that might help those searching.

Sadly the article lists far more recent developments in the treatment of acne compared to rosacea;

  • Topical antiandrogens,
  • ASC-J9 cream,
  • Insulin-like growth factor-1 inhibitors,
  • Peroxisome proliferator-activated receptor modulators,
  • Acetylcholine inhibitors,
  • Acetyl-coenzyme A carboxylase (ACC) inhibitors ,
  • Phosphodiesterase inhibitors,
  • Inhibitors of the interleukin-1β-mediated inflammatory response,
  • Vitamin D analogs,
  • Dapsone,
  • Nitric oxide
  • Probiotics and Prebiotics

Article Abstract

Acne and rosacea: What’s new for treatment?

Dermatol Ther. 2019 Jul 11

Assoc. Prof. Dr. Recep Dursun, Assoc. Prof. Dr. Munise Daye, RA. Dr. Koray Durmaz

Acne and rosacea are two well-known chronic skin diseases in dermatology. There are many known therapeutic options of both diseases, but new treatment agents and therapeutic advances come to the agenda day by day. We would like to summarize new treatment advances for acne and rosacea diseases.

Recent Advances in Rosacea Treatments

There are many treatment options have been applied for rosacea up to now. The traditional treatments in rosacea include topical and systemic agents (see table 2) (11). The researchers aim novel treatment agents for the controlling of the disease and many studies have been reported.

Topical Ivermectin

Ivermectin %1 cream is an acaricidal agent such as permethrin %5 and crotamiton %10. It targets Demodex foliculorum and brevis. It has also decreased the innate and adaptive immune responses, inhibits neutrophil chemotaxis and phagocytosis. In clinical trials, ivermectin has shown to be effective on rosacea lesions after 16 weeks duration. It approved by FDA for the treatment of rosacea in 2014.

Read more: Soolantra

Topical Brimonidine and Oxymetazoline

a-2 adrenergic receptor agonist brimonidine targets the vasomotor dysregulation in rosacea pathogenesis. It has the purpose of relieving symptoms in rosacea patients. Brimonidine %0.33 gel is approved by the FDA for the treatment in rosacea in 2013. Oxymetazoline is a potent a1 and partial a2 adrenergic receptor antagonist. It affinities small subcutaneous vessels lesser than Brimonidine gel.

Read more: Mirvaso and Rhofade.

Intradermal Botulinum Toxin-A

Neurogenic vascular dysfunction can be a crucial pathogenic step in rosacea. Acetylcholine is thought to be effective on cutaneous vasodilatation. Botulinum toxin-A blocks the presynaptic acetylcholine release followed by cutaneous bloodstream control.

Read more: Botox

Laser and light therapies

These modalities typically target the vascular manifestations of rosacea. Such types of laser systems have been tried for rosacea treatment. Pulsed dye laser and intense pulse light were found to be effective with similar efficacy in erythematotelangiectatic rosacea. In different clinical trials, Nd:YAG laser has shown to be effective in erythematotelangiectatic rosacea and papulopustular rosacea. CO2 laser can be beneficial in phymateous rosacea.

Read more: laser therapy

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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2 Reader Comments

  1. Sandra Hall says:

    I’ve got my rosacea under control since going off antibiotics and harsh cleansing and exfoliating. I watched Dr Dray’s YouTube vlogs, took her advice and started using CeraVe hydrating cleanser ( washing and rinsing with my hands ) and moisturizing with the cream in the large tub. An application of an Elta md sunscreen and I’m good to go. Of course I need to watch out for trigger foods, no wine and protect my face from cold or hot winds. My skin is so healthy and flawless now. I’m also able to use RetinA every night which has been beneficial as well. I urge anyone suffering from rosacea, acne or any skin disorder to watch Dr. Dray on YouTube as she is extremely knowledgeable and helpful. What have you got to lose?
    Sandra Hall

  2. Sandra Hall says:

    Oops, I forgot one of the most important things to mention. Rosacea sufferers often, if not always, have transdermal water loss leading to a compromised moisture barrier function. It is crucial for us to trap water in the skin immediately after cleansing with an occlusive moisturizing cream. That has been the single most successful tip I’ve gotten from Dr Dray.
    Hope this helps.

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