VEGF and vasodilation

Written by on September 23, 2005 in research, VEGF with 1 Comment

An in-depth article to do with the effect of VEGF on the vasodilation and vasorelaxation of blood vessels.

Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature

American Journal of Physiology Heart and Circulatory Physiology 286: H946-H954, 2004.

Abstract: Various laboratories have reported that local subcutaneous or subdermal injection of VEGF165 at the time of surgery effectively attenuated ischemic necrosis in rat skin flaps, but the mechanism was not studied and enhanced angiogenesis was implicated. In the present study, we used the clinically relevant isolated perfused 6 x 16-cm pig buttock skin flap model to 1) test our hypothesis that VEGF165 is a potent vasodilator and acute VEGF165 treatment increases skin perfusion; and 2) investigate the mechanism of VEGF165-induced skin vasorelaxation.

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. skincarejunkie says:

    VEGF can be found in TNS Recovery Complex made by SkinMedica. This product has shown to reduce facial redness.

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