Tropisetron (Navoban): rosacea patent filed by Galderma

Written by on February 25, 2009 in patents, Rosacea Topicals with 0 Comments

My regular patent trolling has unearthed something potentially interesting. The anti-nausea drug Tropisetron is patented by Galderma as a treatment for inflammatory skin conditions including rosacea. Tropisetron is officially known as a 5-HT3 receptor antagonist or a serotonin antagonist. Serotonin (5-HT) is found widely distributed throughout the gut and the central nervous system

ADMINISTRATION OF TROPISETRON FOR TREATING INFLAMMATORY SKIN DISEASES/DISORDERS, United States Patent Application 20090048289.

Tropisetron or salt thereof, formulated into diverse pharmaceutical/dermatological compositions, is useful for the treatment of a variety of inflammatory skin disorders/diseases, e.g., eczema, psoriasis, rosacea, acne vulgaris, ulcers, seborrhoeic dermatitis and irritations induced by chemical, physical or mechanical agents, notably rosacea.

Tropisetron has been approved in the past in palliative therapy to prevent or treat chemotherapy induced nausea and vomiting and to treat post-operative nausea and vomiting. Tropisetron is not available in the United States.

Tropisetron has been found effective in treating rheumatic arthritis, IBS, diarrhoea, central nervous system related disorders like anxiety, drug addiction, cognitive functions, myofascial pain, chronic fatigue syndrome, fibromyalgia and certain forms of pruritus.

Further, Claim 8 in the patent application is interesting;  “there is, however, no published data regarding the use of tropisetron in order to treat an inflammatory skin disorder/disease and preferably rosacea”. If indeed Galderma have found this agent to be effective in treating rosacea, they may well end up owning the patent outright.

The claims proposed in the patent embody a topical agent being a gel, cream or lotion with a concentration from 0.0001% to 20%. The claims also mention topical application to the eye and cover oral and sub cutaneous preparations as well.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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