topical antihistamine reduces oily skin and acne

Written by on February 13, 2007 in antihistamines with 2 Comments

This product sounds really interesting for those rosacea sufferers who have oily skin. A H-1 Receptor Antagonist is an antihistamine, which are among the most widely used medications in the world. There is some published research with respect to H1 Antagonists and Atopic Dermatitis. All that I know so far is that this is a patent pending product that will be available in dermatologists offices. As more information becomes available I’ll publish it.

A 4-week, randomized, double-blind, parallel group trial evaluating the efficacy and tolerability of sebum control product in male and female subjects with oily skin appearance and mild to moderate acne vulgaris, Ronald Rizer, PhD, Thomas J. Stephens & Associates, Colorado Springs, CO, United States; Nathan Trookman, MD, Rocky Mountain Laser Center, Colorado Springs, CO, United States; James Herndon, MD, Prsbyterian Hospital, Dallas, TX, United States; Thomas Stephens, PhD, Thomas J. Stephens & Associates, Carrollton, TX, United States.

Excessive production of sebum on acne prone individuals often leaves skin with an undesirable appearance that emphasizes facial shine, acne lesions, and enlarged pores. The factors that often contribute to this appearance include family history, hormonal activity changes, stress, and the use of certain types of birth control pills.

This randomized, double-blind, placebo-controlled trial was undertaken to evaluate a novel treatment containing an H-1 receptor antagonist designed to improve the appearance of oily facial skin in subjects with and without mild to moderate acne vulgaris.

The treatment product contained an H-1 receptor blocker, acrylic copolymer, and botanicals with oil control activity in a hydro-alcoholic gel base. Twenty (20) male and female adult subjects meeting the eligibility requirements were enrolled in this study. At the baseline visit, the investigator graded the severity of facial shine and oily feel on the face using an 11 point analog scale were 0 = none and 10 = severe. Subject’s acne severity was assessed by counting acne lesions and by using a global acne scale. Objective and subjective skin irritation was graded using a 4-point scale with 0 = none and 3 = severe. Triplicate sebum measurements were taken on forehead, cheeks and chin of subjects at each visit. Subjects’ faces were photographed with a digital camera. Subjects returned at 2 weeks and 4 weeks for repeat grading, sebum measurements and photography.

Clinical grading showed that treatment product provided both an immediate and sustained benefit in reducing oily skin appearance. Some subjects showed improved acne conditions. The significance of these findings is discussed in this poster.

Commercial support: None identified.

Poster Abstract P104, American Academy of Dermatology, 65th Annual Meeting February 2-6, 2007, Washington, DC. Published in Journal of the American Academy of Dermatology Volume 56, Number 2.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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2 Reader Comments

  1. pauline says:

    The Made from Earth Rosehip & Hibiscus Face Serum is perfect for my skin. My chin, forehead and especially my nose tend to be oily, but the rest of my face can be really dry. Anything I use to prevent or reduce acne generally dries out my face. I haven’t been able to find this moisturizer at my regular stores lately, so I used another brand’s moisturizer (Dove, I believe), and my face started breaking out by the next day. I’ve read other reviews where people said this moisturizer makes their skin softer than it’s ever been. I guess it just really depends on your skin type. They should sell cheaper samples, so people can try out these kind of products. Oh well. I’m just glad to find it on their website – if your looking for it its:

  2. harpreet singh says:

    i have oily skin.and acnes only on fore head nose.since 1 year i m suffering from this problem.plz suggest me something for it.

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