State of the art in rosacea topical treaments

Written by on December 14, 2023 in research, Rosacea Topicals with 0 Comments

A really easy to access article in Mol. Pharmaceutics has given us a detailed run down of the current status of rosacea topicals and a glimpse into the future of topical treatments.

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

Mol. Pharmaceutics 2023, 20, 8, 3804–3828

https://doi.org/10.1021/acs.molpharmaceut.3c00324

The paper lists the topicals that are promoted as best in class treatments for rosacea:

Topical therapy is often an alternative to oral therapy, since it allows local action related to fewer side effects and simultaneously provides greater ease and convenience of application.

FDA-approved topical therapies consists of metronidazole (MTZ) 0.25%, 0.75%, and 1% cream, gel, and lotion; azelaic acid (AZA) 15% gel; sodium sulfacetamide 10%; sulfur 5%; and sodium sulfate 10%.

In addition, these other formulations are also used as off-label therapies: topical brimonidine 0.33% gel, 1% oxymetazoline cream, 1% ivermectin cream, calcineurin inhibitors such as 0.1% tacrolimus and 1% pimecrolimus cream, topical retinoids, and 5% permethrin. Further sections discuss Timolol, Ivermectin, Calcineurin Inhibitors, topical retinoids, Permethrin, Serine Protease Inhibitor, Pioglitazone, Dapsone (and the list goes on).

The product names here are respectively the familiar Metrogel, Finacea, Clarifoam EF, Mirvaso, Rhofade, Soolantra and more.

After a thorough description of the state of the art, the paper offers a glimpse into the topical futures with sections on nanosystems, probiotics and Anti-TNFα and siRNA.

The paper is well worth your read:

  • Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems Ana Cláudia Paiva-Santos, Tatiana Gonçalves, Diana Peixoto, Patrícia C. Pires, K. Velsankar, Niraj Kumar Jha, Vivek P. Chavda, Imran Shair Mohammad, Letícia Caramori Cefali, Priscila Gava Mazzola, Filipa Mascarenhas-Melo, and Francisco VeigaMolecular Pharmaceutics 2023 20 (8), 3804-3828DOI: 10.1021/acs.molpharmaceut.3c00324
Read more about: research, Rosacea Topicals

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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