SPF-90 inhibits VEGF, IL-1a and MMP-1 induced by UVB radiation

Written by on March 9, 2006 in Sunscreens for Rosacea Sufferers, VEGF with 1 Comment

Inhibition of UVB-induced VEGF, IL-1a and MMP-1 release by a SPF-90 sunscreen

Mar Recasens, PhD, Josep Maria Reig, PhD, Carles Trullas, PhD, Carles Pelejero, PhD, Isdin Skin Research Center, Barcelona, Spain

Ultraviolet radiation is well-known to induce a range of deleterious effects on human skin such as photoaging and photoimmunosuppression, and can lead to the development of skin cancer. The UV radiation increases the release of VEGF, IL- 1 alfa and the overexpression of enzymes such as MMP-1. VEGF provides a major angiogenic activity in tumor progression and invasion. IL-1a is a proinflammatory cytokine that stimulates proliferation, differentiation, and activation of various epithelial and endothelial cells, and the production of other cytokines involved in inflammatory skin diseases, histamine release, and systemic and local immunosuppression. The matrix metalloproteinase (MMP) enzymes are responsible for breaking down macromolecules of the skin ECM; in particular, MMP-1 can hydrolyze type I and III collagen, and seems to play a crucial role in the disorganization and progressive degeneration of dermal ECM. We used human skin equivalents to study the efficiency of a SPF-90 sunscreen in preventing the VEGF, IL-1a and MMP-1 release induced by UVB radiation. Skin equivalents, either treated or untreated with SPF-90 sunscreen at 2 mg/cm2, were exposed to 300 and 600 mJ/cm2 of UVB. To assess the UVB-induced damaging effects, we investigated the following events 24 hours after UVB irradiation: VEGF, IL-1 IL-1a, and MMP-1 release in the culture medium by ELISA and cell viability. The results of this study reveal that the unprotected UVB-irradiated skin equivalents show increased VEGF, IL-1 IL-1a, and MMP-1 release, and decreased cell viability. In contrast those skin equivalents treated with sunscreen show a significantly lower VEGF, IL-1 IL-1a, and MMP-1 release and higher cell viability. We concluded that this SPF-90 sunscreen provides an efficient protection against UVB-induced VEGF, IL-1 IL-1a, and MMP-1 release.

Author disclosure: Researcher at Isdin Skin Research Center. 100% sponsored by Isdin Skin Research Center.

Poster Discussion Session P2610, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.

Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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