Soolantra is both anti-inflammatory and anti-demodex

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This paper is exploring the reasons for Soolantra’s success in treating the lumps and bumps of rosacea; its dual method of action – both as an antiparasitic and anti-inflammatory.

The research was able to show that along with the improvement in rosacea symptoms, trialists had a significant reduction in the amount of demodex mites present as well as the amount pro-rosacea inflammatory markers present in their skin.

This paper looks to be based on the results of a trial to chase how Soolantra works, conducted in 2016.

Overall, Soolantra seems to be gathering favourable reviews, and this research suggests that this success is likely to be sustained into the future as more rosacea sufferers try Soolantra and potentially experience a benefit.

 Article Abstract

Dual anti-inflammatory and antiparasitic action of topical ivermectin 1% in papulopustular rosacea.

J Eur Acad Dermatol Venereol. 2017 Jun 27.

Schaller M, Gonser L, Belge K, Braunsdorf C, Nordin R, Scheu A, Borelli C.
BACKGROUND: Recently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream.
It is assumed to have a dual mode of action with anti-inflammatory capacities and anti-parasitic effect against Demodex, which however has not yet been demonstrated in vivo.

AIM: To find scientific rationale for the dual anti-inflammatory and anti-parasitic mode of action of topical ivermectin 1% cream in patients with rosacea.

METHODS: A monocentric pilot study was performed including 20 Caucasian patients with moderate to severe rosacea, as assessed by investigator global assessment (IGA score ≥ 3) and a demodex density ≥ 15/cm2 .

Patients were treated with topical ivermectin 1% cream once daily (Soolantra) for ≥12 weeks. The density of Demodex mites was assessed with skin surface biopsies.

Expression of inflammatory and immune markers were evaluated with RT-PCR and by immunofluorescence staining.

RESULTS: The mean density of mites was significantly decreased at week 6 and week 12 (p<0.001).

The gene expression levels of IL-8, LL-37, HBD3, TLR4 and TNF-α were downregulated at both time points. Reductions in gene expression were significant for LL-37, HBD3 and TNF-α at both follow up time points and at week 12 for TLR4 (all p<0.05). Reduced LL-37 (p<0.05) and IL-8 expression was confirmed on the protein level by immunofluorescence staining.

All patients improved clinically and 16 out of 20 patients reached therapeutic success defined as IGA score ≤ 1.

CONCLUSION: Topical ivermectin 1% cream acts by a dual, anti-inflammatory and anti-parasitic mode of action against rosacea by killing Demodex spp. in vivo, in addition to significantly improving clinical signs and symptoms in the skin.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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7 Reader Comments

  1. Pinky says:

    You’re skeptical about the role of Dermodex Mite in Rosacea David, no? I have used this on a pre rhinophyma nose and I’m not sure if it’s working or not. I reverted back to topical clindamycin and it seems to bring down the swelling far more but the alcohol irritates the sebaceous glands, and the skin somewhat which is problematic.
    My symptoms are all nose based and Soolantra is receiving rave reviews but it kinda clogs my nose pores ans creates a bumpy, white heady texture.
    There is no doubt through in the initial week it massively reduced the stinging and burning and inflammation.

    • Katie says:

      I wonder if it’s not the ivermectin that’s causing the clogging, but the compound itself? My skin gets red and inflamed with alcohol-based products or even gels (rosex gel for example), yet the creams tend to clog me up and I get breakouts. It’s tricky finding that happy medium. You can get your doctor to write a script for a pharmacist to make soolantra with a different compound – they often know which ingredients would work better – and it can be trial and error until you find the right compound that works for you. You could probably get the clindamycin done in a compound too.

  2. felix says:

    This Medication is over rated and over priced .i was prescribed this med and make my skin terrible very painful to touch follow by face swelling specially the nose this med base on cetaphil .loaded with alcohol is no good for rosesea at all irritates the skin further more than what already is .this med should it be investigated .tons of complaints on it from allergic reactions to burns etc .becareful no one with rocesea should use any medication that the contents are alcohol base like this ….

  3. Pinky says:

    Hi Felix,

    The alcohol in Soolantra is listed as cetyl alcohol, which according to the Paula’s Choice website is soothing and beneficial. See link below.
    I’ve not had great success with Soolanta as I find it too rich but its getting excellent ratings on many online med review sites. It just mightn’t be suitable for my very tender, phymatous, actinic nose!

    “Just to be 100% clear, there are other types of alcohols, known as fatty alcohols, which are absolutely non-irritating and can be exceptionally beneficial for skin. Examples you’ll see on ingredient labels include cetyl, stearyl, and cetearyl alcohol. All of these are good ingredients for dry skin, and in small amounts fine for any skin type as they give a pleasing texture and help keep ingredients stable in products. It’s important to discern these skin-friendly forms of alcohol from the problematic types of alcohol.”

    http://www.paulaschoice.com/expert-advice/skincare-advice/basic-skin-care-tips/alcohol-in-skin-care-the-facts.html

  4. David Pascoe says:

    Comment via email.

    “Please tell your people that taking probiotics might help. I think they have helped me. “

  5. Dana says:

    I have been using this for quite a while and I cannot live without it. Soolantra is the only thing that has worked for my stubborn rosacea. My skin looks really nice and barely any bumps when I wear make up,I love how smooth my skin is. I have not had any burning with this medicine and it has not broke me out or irritated my skin any further. I will not go without this medicine. Its the best!

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