Soolantra for Ocular Rosacea

soolantra-ocular-rosacea

This just published article is describing some clinical work has been concluded that proposes using topical Ivermectin (Soolantra) to treat ocular rosacea. Soolantra so far has only been approved as a treatment for the papules and pustules of rosacea.

Soolantra is thought to be effective against rosacea because of its anti-demodex and anti-inflammatory properties.

The paper is authored by Martin Schaller, from the Department of Dermatology, Eberhard Karls University Tuebingen in Germany. Dr. Schaller is known to rosacea sufferers through his research into a new way to diagnose rosacea, and how Soolantra works.

We can see from the above photos at baseline, 14 weeks and 35 weeks that the patient enjoyed significant relief from their symptoms. We also learn that their demodex mite count dropped to zero.

The Demodex mite count using Standardized Skin Surface Biopsies (SSSB) prior to therapy was 21 mites per cm2. After 14 and 35 weeks of monotherapy with 1% ivermectin daily no mites could be detected.

Dr. Schaller was a member of the Bayer, Galderma and Marpinion advisory board during the past 2 years and has received lecture fees from AbbVie, Bayer Healthcare, Galderma and La Roche‐Posay.

Dr. Schaller was kind enough to provide a copy of the paper as only the title is available online.

Treating Ocular Rosacea with Soolantra

The paper describes the following treatment regimen;

The patient was instructed to apply one small pea size (approximately 1 gram) of cream on the forehead, chin, nose and cheeks (i.e. a total of 5 pea-sized amounts).

The product was to be spread in a thin film over the entire face. In addition, he was asked to apply one half pea-sized amount on each closed eyelid and next to the lid edges while carefully avoiding the eyes.

So you can see the instructions are to apply the Soolantra cream to the closed eyelid, around the lid edges, but not on the eye as irritation will occur.

A new Ocular Rosacea Treatment?

Hopefully this research might lead to another viable ocular rosacea treatment. Professor Schaller points out, though, that a large randomised clinical trial is needed before this result can be confirmed and a new ocular rosacea treatment approved.

Successful therapy of ocular osacea with topical ivermectin.

M. Schaller, K. Pietschke

 2018 Mar 12. doi: 10.1111/bjd.16534. [Epub ahead of print]

Soolantra Off Label

This is an example of an off-label treatment that may be of benefit to rosacea sufferers. Doctors are allowed to prescribe prescription-only treatments for conditions for which they were not offically FDA approved, on the condition that they take into consideration the known risks. All drugs have risks and you need to be sure that you understand the additional risks you may be exposing yourself to from an off-label usage.  See Off Label Treatments for Rosacea for more information.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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19 Reader Comments

  1. Frank says:

    This would so be welcome as I’m tired of resorting to Minocycline. Is Soolantra available in Canada?

  2. Heather Russell says:

    In addition to severe ocular rosacea, I have an allergy/ sensitivity to the preservatives used in otc eye drops for dry eyes. I can use the preservative free individual ampoules. My condition has been well controlled for two years using the following:

    I am on Doxycycline USP 40 mg capsule – one a day. My ophthalmologist prescribed preservative free eye drops Dexamethasone .01% which I have compounded every two weeks and I use one drop in each eye at bedtime

    I use ocusoft baby eyelid wipes to wash my lids ( I was sensitive to adult preparations) in the morning followed by gauze wipes and warm water. ( I found that the detergent residue on face washers caused breakouts).

    At night I use gauze and warm water to wash my eyelids.

    During the day, I use the individual ampoules of eye drops for dry eyes ( “Refresh Optive Advanced” is my favorite.) If my eyes become itchy during the day, I do a gentle lid scrub with gauze squares and warm water.

    Hope my treatment success might translate to success for someone else!

  3. Elaine A says:

    You could potentially cure the condition in just 2 weeks with oral ivermectin+oral metronidazole and avoid potential damage to your eyes, corneas and meibomin glands. The 2 oral drugs are available as generics about $13 with insurance or about $52 full retail. The oral treatment will work to quickly kill the mites in the glands. The topical treatment is only effective on the surface of the skin as you cannot put it in the glands or follicles. That explains why the topical treatment takes so much longer than the oral treatment. The 2 treatment protocols together could be even more effective.

    The oral treatment is much cheaper than Soolantra which will cost the insurance company or uninsured patient over $500 per tube. The oral treatment might not be recommended for some patients depending on their drug tolerance and health issues.

    The combined oral treatment worked for me.

    https://www.sciencedirect.com/science/article/pii/S120197121201315X

    • Frank says:

      Will ask my ophthalmologist; this looks quite promising. Did you feel any side effects especially from the metronidazole?
      Thanks, Elaine!

      • Elaine A says:

        No, I didn’t have any side effects. You cannot drink alcohol while taking the oral metronidazole and for 72 hours after finishing the last tablet. Good luck!

        • Frank says:

          So is this a continuous treatment or for X number of days? Either wayI’m feeling encouraged that through you and John Lafarge, relief may be near..especially for my eyes.

          • Elaine A says:

            Yes, this is a 2 week treatment. It is 2 doses of oral Ivermectin taken 1 week apart on an empty stomach with a large glass of water. The doses of Ivermectin are based on your weight. 200 micrograms per Kilogram of body weight. For me, the dosage worked out to 12mg or oral Ivermectin per dose. At the same time you take oral Metronidazole 250 mg, 3 times a day for the 2 week time frame (no alcohol while taking the oral metronidazole for the 2 weeks + 72 hours after last tablet). Then you are done!

            I had occular rosacea/blepharitis demodex for years. It was misdiagnosed as allergic conjunctivitis. I finally figured out what the real problem was when it got really bad last year. That is when I found that paper. The oral treatment worked. I am six weeks post treatment. Eyes and skin are clear. Hope this helps!

      • Hi Frank,
        I’ve been on Rosiver for almost 2 years. Worked for me. Noticed dramatic improvement in 10 days. I am now on a maintenance plan and use it twice a week.
        Redness around forehead, cheeks and eyes is completely gone.
        I had a bad demodex problem. Mites are now killed.
        All the best.

        • Frank says:

          Much appreciated John, Thanks!

          • Frank says:

            Elaine, looks like I may have difficulty obtaining oral ivermectin. Called my local pharmacy and sure enough they can only get under special approval.Will have to convince my Doc. In ematime I’ll ask hi to prescribe Rosiver.
            https://www.theglobeandmail.com/news/national/why-world-beating-tropical-drugs-are-so-hard-to-get-incanada/article33469954/

          • Elaine A says:

            Frank,
            My family doctor prescribed the oral treatment for me when I explained the problem with the mites. I had been using Cliradex wipes which really helped. But I could not stop using the Cliradex or the mites came right back. The oral treatment really helped – for me the mites were really entrenched in my eye lids and skin. I’m at 6 weeks post oral treatment and still clear..

            The Soolantra should help in the meantime. Some people have been able to use just the topical and clear them. I hope which ever solution you end up with, it works!

            Good Luck!

            Elaine

  4. rebecca says:

    After 12 months on Doxycycline (Australia) and a stomach ulcer to show for it, I have used 2 x tubes of Soolantra over 6 months. I have completely cleared my Rosacea, apart from a few small bumps that arise ONLY when my ulcer has been playing up – if i’ve had a bad stomach guaranteed the Rosacea flares up. I am now using my third tube of Soolantra, twice a week on maintenance plus a few dabs on the occasion Rosacea spot as spot treatment. I wish I had tried this cream prior to going on the Doxy, I would have literally saved my stomach. Whilst I understand how debilitating this condition is, my thoughts are to AVOID all oral medications and give Soolantra a go first.

  5. Logan stewart says:

    I have had red checks for almost two years I have tried slontra,finacea, avene redness, rofade and some I can’t remember. Can someone please tell me what had cleared there redness up on there face??

    • Joyce says:

      Try colloidal silver topically as well as orally. It worked great for taming the redness. I make my own now, but you can purchase Sovreign Silver at Walgreens (they will order it for you if not in stock). It’s about $20 for an ounce. Expensive in the longterm, which is why I bought my own machine to make it myself. Don’t worry about it turning you blue, which only happens to people who extremely consume it over many, many years time. Smaller particle ionic silver doesn’t collect in the body which is what Sovreign Silver is. Research it for yourself. It has so far healed my ear infection, eye infection, a sore on my dog, my hubby’s eczema. I take about an ounce daily as a preventive. Try it! What do you have to lose!

  6. Comments via facebook posting.

    “This is encouraging, but soolantra is overpriced. Ivermectin can be purchased cheaply at the farm store….maybe I could make a topical.”

    “Ivermectin cream 1% (sold as rosier in Canada) ‘cured’ my rosacea. A 60g tube sells for $193 CN but luckily I have an insurance plan so it costs me $40. I only use it now for flare-ups so a tube lasts 10 months. It took about 2 months initially to get the rosacea under control.”

    “I used it for my ‘periocular dermatitis’. Or at least that’s what name the dermatologist gave it. Soolantra ‘cured’ my pd and rosacea.”

    “Soolantra has cured my rosacea. I used daily for 6 MO I now use nothing no flares no problems.”

    “I use Soolantra and it is SERIOUSLY the miracle cream!”

    “Soolantra gave me my “life” back”

    “After using Soolantra for two weeks, the skin on my face was as soft as a babies behind. I’m not kidding! after four weeks my breakouts stopped. I’m also on a low dose of doxycycline. I do have a lot of red capillaries under my skin so I will have to see if I need them zapped once summer is here.”

    “LOVE Soolantra – I have tried Minocycline in past and this time took it and 1 week in had a horrible reaction (purpura) – Soolantra has made my skin soft and within 2 weeks almost all red is gone and skin is close to normal”

    “Expensive and didn’t help me”

    ” I used it for 10 days last May, my skin felt like it was on fire. Had a reaction to the mixing agent, took 3-4 days to recover after discontinuing”

  7. Jack says:

    Does anyone know where to purchase oral ivermectin? Thanks!!!

  8. “I paid $85… it was a huge outlay.. but on the chance it worked i save up the money.. it has helped me.”

  9. Kathy says:

    I’ve had ocular rosacea for 9 years now and have tried everything from Tetracyclines (Minomycin), Lipiflow, IPL (both E-Eye and Lumenis), tea-tree oil cleansers and currently 1% Ivermectin cream. My eyes reacted to the additives in Soolantra when I used it on my face so would not be willing to use it on my eyelids, but I have recently had 1% Ivermectin cream compounded here in Australia with a simpler base. I have been using it for 2 weeks and so far it has only had a marginal effect but it may be useful for others on this forum. The compounding pharmacy is the Wesley Pharmacy in Brisbane and the base they use is Versapro which I believe does have a bit of preservative but not all the additives of Soolantra and much less expensive. A Sydney pharmacy told me they have compounded it in an eye ointment base as well.

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