SkinMedica Redness Relief CalmPlex launches to replace Cutanix DRL

Written by on January 31, 2011 in cutanix, Red Face of Rosacea with 8 Comments

We were tipped off by a comment on the blog posting about Cutanix going offline, to the possible future availability of a Cutanix like product. The commenter, who works for SkinMedica told us that;


Bioform was sold to Merz Aesthetics.
In that sale Cutanix was sold to SkinMedica.
They will launch the product this Jan so stay tunned!

The last news from Cutanix was in April 2007 when they disappeared off the internet and a warning letter from the FDA surfaced. At that stage DRL was a part of my regular regime, it kept my facial redness under pretty good control. I, along with many others was sad to hear that this product was no longer available.



Now SkinMedica has announced the availability of their formulation of the Cutanix DRL, as a new product called Redness Relief Calmplex Treatment Moisturizer.

This product is available in 1.6 ounces (50ml / 45gm) for $80 at

By comparison we have been used to paying $45.00, or less with a discount, for 1.7 oz of Cutanix DRL.

How to Purchase

SkinMedica products are available at physician offices across the US. You can use their Physician Finder to find one close to you. Alternatively you can purchase RR CalmPlex from their web site and designate any physician when you place your order.

Ordering outside the US is to be possible via the international distributors for SkinMedica.

Does it Work ?

The Redness Relief Camplex contains the same active ingredient from the Cutanix Dynamic Relief Lotion, namely 4-Ethoxybenzaldehyde. SkinMedica call this ingredient CalmPlex. Cutanix’s moniker was Quadrinone.

SkinMedica tell us that they have commissioned Dr. Zoe Draelos to undertake pilot studies into the effectiveness of Redness Relief CalmPlex and that the results of these studies are on file at SkinMedica. Of course not being able to read this studies does mean that we can’t see for ourselves how effective is has proven to be. Perhaps in the future more research will become available.

The publicity for RR CalmPlex also tells us that in in-vitro (i.e. in the lab, not on skin) CalmPlex was found  to be an inhibitor of Prostaglandin E2 (PGE2), claimed to be a key natural vasodilator.

A small pilot study published in 2005 concluded that this benzaldehyde-derived anti-inflammatory agent may be useful in reducing facial erythema in a rosacea model.

Redness Relief CalmPlex Ingredients

Water/Aqua/Eau, Glycerin, Ethoxydiglycol, Squalene, Isocetyl Stearate, Simmondsia Chinensis (Jojoba) Seed Oil, Isostearyl Palmitate, Mineral Oil, Glyceryle Stearate, PEG-100 Stearate, Niacinamide, Glycereth-7, PEG-7 Glyceryl Cocoate, 4-Ethoxybenzaldehyde (CalmPlex), Cetyl Ricinoleate, Polysorbate 20, Polyacrylamide, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Methylparaben, Propylparaben, Butylparaben.

Defunct Cutanix DRL Ingredients

By comparison, here are the Cutanix DRL Ingredients. Note that Cutanix referred to 4-Ethoxybenzaldehyde  as Quadrinone.

Purified Water, Glycerin, Ethoxydiglycol, Glyceryl Stearate (and) PEG 100 Stearate, Squalane (vegetal), Isocetyl Stearate, Isostearyl Palmitate, Simmondsia Chinesis (Jojoba) Seed Oil, Lipovol MOS-130, Niacinamide, Glycereth-7, PEG-7 Glyceryl Cocoate, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, Quadrinone, Cetyl Ricinoleate, Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Butylparaben (and) Propylparaben (and) Isobutylparaben, Polysorbate-20

Are you Excited?

I can well remember the sad thoughts when Cutanix was no longer available. Will you be tempted back to try RR CalmPlex?

Related Articles

Read more about: cutanix, Red Face of Rosacea

About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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8 Reader Comments

  1. Comment via email from Mary:

    “Would I try it? Not a chance. I’ve actually never seen a product with five different types of cancer-causing paraben”

    • Susan says:

      Hi there . I came across several bottles of cutanix, still in sealed cases. I have been using it I love it. I have four boxes of six each, maybe more for $250 a box if you buy all four $800

  2. Diane says:

    I’m at the bottom of my last bottle of Cutanix Gelee skin cleanser. Who knew it had disappeared? I love this product so much, and it’s been so helpful. Does anyone have a comparable cleanser to recommend?

  3. I was sent a jar of Redness Relief CalmPlex to try it out and I have to say that it is nice to have it back in my regime. I missed having it to use after exercise when I was red and flushed and need to reduce the red a quick as I can.


  4. John N says:

    Whats the deal with the five different types of cancer causing paraben? I really want to try this product but effects like that should not be overlooked.

  5. Steven M says:

    Hi David,
    I would like to know if you still use Skin medica redness relief
    and is it worth the money?
    Do you only use it once your flushed?
    Does it help in preventing flushes?
    thank you

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