Promiseb Topical Cream for Seborrheic Dermatitis


I was alerted to the launch of a product called Promiseb by a comment left on the Sebclair for Seborrheic Dermatitis post. Since then the news web sites are also covering the press release. Promiseb (probably pronounced Promi-seb) is launching in the U.S. via Promius Pharma, after being licensed from Sinclair Pharma in 2007.

Promiseb Topical Cream (Sebclair) is a non-steroidal, prescription only cream for the treatment of seborrheic dermatitis. It has demonstrated anti-inflammatory and anti-fungal properties. Sebclair is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s (and now Promiseb’s) claims to fame is that it contains no corticosteroids or immunomodulating agents.

Promiseb is claimed to “Significantly reduced Malassezia yeasts, the organisms that may cause seborrheic dermatitis, by 94%”. These claims are more interesting when you consider the ongoing discussions like Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective, Could M. Globosa Cause Rosacea? and Real cause of seborrhea discovered!.

For a description of the ingredients and suggested method of action see Sebclair for seborrheic dermatitis.

From the press release: Sebclair launched in the US by Dr Reddy’s Laboratories’  subsidiary Promius Pharma, LLC

Jeff Wasserstein, President of Promius Pharma, said “We are very excited about Promiseb Cream because it has the potential to replace both anti-inflammatoryand antifungal treatments in patients with seborrheic dermatitis. In a clinicalstudy Promiseb was shown to have efficacy comparable to desonide cream 0.05% atdays 14 and 28 with fewer relapses.

“Promiseb Cream also has an excellent safety profile with no restrictions onage, duration of use or application on the face.” He continued, “We are very enthusiastic about this product because our clinical research shows thatPromiseb Cream may be used as a first-line treatment for seborrheic flares andfor long-term maintenance”

No Active Ingredients?

A supporting web site for Promiseb is online at contains a very interesting insight into the Promiseb product itself ;

What is the active ingredient in Promiseb Cream?

Promiseb Cream is a prescription-only, nonsteroidal FDA-cleared medical device and has no active ingredient. However, Promiseb Cream has demonstrated both anti-inflammatory and antifungal properties.

The makers of Promiseb do say that those who are allergic to shea butter or shea nut oil should not use their product though.

It does seem to be an unusual situation; a prescription only medicine that claims to have no active ingredients.

Promiseb Ingredients

Here is the full list of ingredients as detailed in the Promiseb Prescribing Information.

Purified Water, Isohexadecane, Butyrospermum parkii, Pentylene glycol, Ethylhexyl palmitate, Cera alba, PEG-30 Dipolyhydroxystearate, Bisabolol, Polyglyceryl-6 polyricinoleate, Tocopheryl acetate, Hydrogenated castor oil, Acifructol complex, Butylene glycol, Magnesium sulfate, Piroctone olamine, Allantoin, Magnesium stearate, Disodium EDTA, Vitis vinifera, Ascorbyl tetraisopalmitate, Glycyrrhetinic acid, Propyl gallate, and Telmesteine.

User Reviews

Auburn-NH has posted an early review of Promiseb, from using a doctor supplied sample.

Savings Coupon

Promiseb is offering a 50% discount off your co-pay or $40, whichever is less. For more information see Promiseb Savings Coupon.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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33 Reader Comments

  1. Larry Ferlazzo says:


    Based on your experience and knowledge, are any of the ingredients known to aggravate rosacea (recognizing, of course, everybody has their own unique issues).


  2. Oh if only such a difficult question had a simple answer 🙁

    None of the ingredients look like obvious no-no for all rosacea sufferers – that is about I can say for now. Hopefully some user reviews will surface over time.

    Any Europeans out there already tried it ?


  3. jiggyp says:


    I have to admit- this product has been pretty effective so far for me. Been using it for about 2 weeks and results have been outstanding so far. Redness around the corner of my nose have been reduced, no itchiness or skin irritation so far..

  4. Joek says:

    So Promiseb is the same as Sebclair? Is Sebclair the same as Atopclair? I can only get Atopclair where I live, but it’s hard to find any information differentiating the two.

  5. MBW says:

    Agree with above reviewer, it is working really well on sides of nose and forehead where I get SB. NOTHING else has worked. I love this stuff so far, its really cleared up my face and I’ve only been using a few times a week – no new flare-ups since i started!!! Thank goodness I was giving up hope.

  6. Auburn-NH is continuing to let us know how her use of Promiseb is going here: My experience with Promiseb

    Thanks for your updates Auburn !

  7. TZK says:

    my son is 10 and has SD around his nose. he has been
    putting Promiseb on for 1 wk now. how soon should we
    be seeing some improvement?

  8. Hello TZK,

    In one clinical trial comparing Promiseb to Desonide 0.05%, participants saw a benefit after 14 days of use.

    all the best,

  9. Will stevens says:

    I have been using promiseb for over a week now and see a marked improvement. Moisturizers never worked and seemed to exacerbate the problem. So far, I only have good things to say about promiseb. I wish it wasn’t so expensive. Insane, but what can we do ?

  10. Erik says:

    I have been using Promiseb for about a week so far. It seems to be working well around my nose, but every once in a while I get a strong smell that smells like an ashtray. Ever heard of that before? Is there an ingrediant that might cause that?

  11. joe says:

    Hi, I just used promiseb for the very first time and my wife said its made my face a bit more red. Is this normal? Does it irritiate the face, before it starts to work? I know my doctor told me 14 days, but I wasn’t expecting it to get worse..

  12. Thanks to a comment left in the support community area by stingray326 –

    The manufacturer of Promiseb is offering co-pay rebates of 50% or $25.00 whichever is less.


  13. tonys says:

    was looking forward to trying a non-steriod treatment for SD, tried promiseb (atopiclair in Oz) and after four days my skin was worse, was not going to persist for 10 more days. Expensive, ineffective in my case.

  14. tonys says:

    PS great site!

  15. Amilee says:

    I’ve been using Promisehb for 14 days now. For the first 4 days it made my skin much, much worse. It has slowly been drying up the blisters (or whatever you might call the pimple-type irritation) and the itchiness has lessened.

    It seems to make the blisters worse at first then better as the day goes on.

    I’m disappointed that it hasn’t been more effective, but I’m hopeful.

    for the past 2 years I’ve been using Nystatin, which actually kept it at bay for a while – even cleared it up for a couple months. But it came back b/c I stopped applying.

    I didn’t know it was a sort of skin condition. I thought I’d just contracted something from someone.

    Has anyone else has this worse-before-better reaction to Promisehb?

    • chris says:

      Promiseb did nothing for my SD. What it did do was make my skin much much much worse! Everything on my cheeks, nose and forehead is bright red and burns. I’m so disgusted with this product. It simply does not work for some of us who have been suffering for years!

  16. mlofty says:

    Just got prescribed Promiseb today for my rosacea and SB. Does it reduce redness as well as getting rid of the dry skin? Ive tried Elidel which contained steroids and it made my skin less flaky but far more red. Almost as if my skin was glowing. If someone can give me their experience with Promiseb it would be greatly appreciated. Thanks

  17. Comment via email from Anthony:

    “I had a rash develop over my face to a point where at least 80% of my face was red, inflamed and itchy and flaky, I thought it was SD but the doctor said it was rosacea and prescribed steroid cream. I didn’t want to use a steroid as I’d heard it perhaps caused the rosacea in the first place. I heard about Mario Bedescu on, ordered some from the US, rash gone, flaking gone, no sign of previous symptoms! The promiseb didn’t work on my face, it did work on a small patch on my chest. I don’t know whats going on with these rashes but I have them under control after a decade of insecurity and discomfort. Try Mario. Hope this helps”

  18. Heather says:

    I just got this from my derm but he did not say whether or not it should still be used with rosacea topicals. Does this also do the job of metrocream?

  19. Hi Heather,

    I think the best answer to that question comes from your derm as I haven’t seen any evidence of how well Promiseb can replace metrocream. If you have seborrheic dermatitis as well as rosacea then using it together is probably beneficial.

    I was slightly surprised to see the makers of Promiseb claiming that their product contains no active ingredients – despite it being a prescription only medication. Weird.

    all the best,

  20. Tma says:

    Does promiseb topical cream work for dark spots?

  21. Angela Platt says:

    It looks like Promiseb has taken the color out of our pillowcases. Has anybody else experienced this?

  22. TML says:

    I’ve been using Promiseb for about 6 months now, and I love it! I temporarily stopped (sometime in November) in order to use up the rest of a tube ketaconozole (sp). However, my scaly skin came right back within 7 days. I immediately went back to Promiseb. I know only have very, very, very light flaking on my nostrils and occasionally near my hair line. I don’t know where I would be without Promiseb. Before I started using it, the scaling and flakiness was all over, and I even had dark patches on my skin near my mouth. It’s a life saver! And a definite keeper!

  23. Jannette says:

    Hi Joek, Atopiclair is different to Sebclair. Atopicair is for the treatment of Atopic dermatistis, whereas Sebclair treats Seborrheic dermatitis.

    From what I can find so far, Promiseb is the same as Sebclair.

    Sebcliar will be available in the Asia Pacific region soon. Refer to the Invidia website for details:

  24. floyd fletcher says:


  25. debbie says:

    I am 46 years old and have rosacea acne. I had been using metrogel for the last year and it was working great on the acne, still had redness and a lot dead skin around my nose, but I was ok with that. It slowly stopped working on my acne after about a year. Started using Promiseb about a month ago and I am very pleased. While I still have some redness, the acne is gone again and my complexion is looking pretty good. Happy to have found this stuff; hope it works for a while.

  26. Terry T Tutor says:

    My Doctor has put me on Cleanser called AVAR Cleanser, is it safe to use my Promiseb Topical Cream after using the Avar cleaner on face.

    Thanks for answer

  27. Scavenger says:

    About four years ago SD (or whatever it is) started showing up badly on my bald scalp. Insult to injury. My first dermatologist launched me on a 2 year steroid nightmare. My second Dermatologist is a bit more homeopathic and we tried many creams, lotions, shampoo’s and techniques. On one visit after some mild improvement, almost as an aside she suggested we try the Promiseb Complete (kit with scalp wash). Halle-frickin-lujah! It has been 3 months now and I am on my second tube. An occasional pimple here and there on my forehead but I am almost normal again. There are some faint red blotches that I am guessing only I notice. I apply twice a day to my entire scalp after a 15+ minute cool pack and 15 min or so air dry. Kind of pain but I don’t really care anymore. Now if I could get a bigger tube, bucket or 55gal drum I would be ecstatic.

  28. Ask says:

    This week I went to see a dermatologist regarding the light patches around my mouth and sides of nose. While talking to the doctor I also brought to her attention how dry itchy and flaky my scalp had been for the past years and that id try just about every shampoo out there. Before she address my face concern she took a look through my scalp. Once she finished that she proceeded to tell me that was the leading cause of the light patches was because of my scalp ( seborrhea dermatitis). Has anyone else experience the light spots on the face? And if so how long after using promiseb did you see results ?

  29. Kristian says:

    I have been using Sebclair along with my Elidel treatment. It definitely helps on the itching! Been using it for 6-7 days now. I think it helps on the small spots in the affected areas.(I only suffer under the nose and on the sides of the nose)

  30. Kerri says:

    Promiseb is a life saver! Years and years of redness, scales, ITCHING and pain…GONE! Been using for 4 days, around nose and mouth. Tried Elidel, ketoconazole, steroids, you name it. Every soap, soap less cleanser, lotion. Amazed with my results. Hope others are able to see the same results 🙂

  31. Cindy L says:

    Sorry to be late to the comments here, but I wanted to report on my experience using both Sebclair and Promiseb. I have a mild case of rosacea and have also battled SD on the forehead and eyebrows, plus around the mouth and nose.

    Sebclair is much cheaper, although my dermatologist found a pharmacy that discounts Promiseb quite a bit — so I’ve been sticking with the latter. Sebclair was thinner in consistency, but same effects as Promiseb. I feel that Promiseb is thicker and more moisturizing, yet also absorbs quickly after application.

    Results for Promiseb can take up to two weeks, according to patient info on the site, but I noticed some improvement after using twice daily for three days. Users should note that a common side effect is stinging and burning at the start, especially when you first start using it and your skin is more “raw” than usual. (Which is why you’re using it, right?) The stinging sensation lessens after a few days of use — and the skin improves.

    Promiseb isn’t a quick fix for me, but it does work beautifully on mild rosacea and SD after consistent use for more than two weeks. Keep using it and you’ll see more improvements in redness, eyebrow itching, roughness, etc. The quality of my skin has improved a lot — almost better than using an anti-wrinkle cream — after a month of use. Ask your dermatologist to help you find the best price available. Shop around. Or use Sebclair instead — it’s almost as good.

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