Sebclair for Seborrheic Dermatitis

Written by on May 8, 2008 in Rosacea Topicals, seborrheic dermatitis with 29 Comments

sebclairThis recently published paper investigates the effectiveness of a `novel steroid-free cream containing multiple active ingredients’, called Sebclair to treat facial seborrheic dermatitis.

This product sounds quite interesting for rosacea and rosacea/SD sufferers. Little information about Sebclair is currently available on the internet.

Sebclair (MAS064D) is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s claim to fame is that it contains no corticosteroids or immunomodulating agents. The paper’s authors admit that it is difficult to know which compound is responsible for Sebclair’s success as a treatment.

The authors state “We believe that the major activity is probably due to the synergistic effect of both piroctone olamine, for its antimycotic action, and glycyrrhetinic acid, for its anti-inflammatory action.”

Sebclair Ingredients

Shea butter6%Emollient
Piroctone olamine1%Antimycotic
Alglycera1%Anti-inflammatory and keratolytic
Vitamin E1%Anti-inflammatory and antioxidant
V. vinifera0.1%Anti-oxidant
Telmesteine0.01%Anti-inflammatory and antioxidant

The following descriptions of each ingredient is supplied in the full text of the paper.

Alglycera is a compound combining the anti-inflammatory properties of glycyrrhetinic acid and the keratolytic properties of allantoin.

Glycyrrhetinic acid, extracted from the licorice root, exhibits anti-inflammatory properties in different organs in several animal models,
with a potency similar to that of indomethacine. Its chemical structure is similar to that of cortisone and has been shown to potentiate the action of hydrocortisone

Piroctone olamine is an antimycotic effective against Malassezia spp.

The standardized extract of V. vinifera (grapevine) in Sebclair contains 40% of epigallocatechin gallate, a proanthocyanidine that prevents oxidative damage to the endothelium, with maintenance of optimal blood supply. It works as an antioxidant synergistically with telmesteine and Vitamin E.

Shea butter, from Butyrospermum parkii, is composed of tryglycerides and fatty acids, including linoleic acid, rich in phytosterols and tocopherols. The action of shea butter is enhanced by isohexedecane, another emollient present in the formulation.

If you live in the EU and suffer from SD, please do let us know how you like Sebclair, by leaving a comment below.

Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial, J Eur Acad Dermatol Venereol. 2008 Mar;22(3):290-6. S Veraldi, A Menter, M Innocenti, Institute of Dermatological Sciences, University of Milan, IRCCS Foundation, Policlinico, Mangiagalli and Regina Elena Hospital, Milan, Italy; Baylor University Medical Centre, Dallas, TX, USA, European Institute of Dermatology, Milan, Italy

Aim: MAS064D (Sebclair) is a novel steroid-free cream containing multiple active ingredients. Objective of this pilot study was to evaluate the efficacy and safety of MAS064D in the treatment of mild to moderate SD of the face.

Methods: Patients (n= 60) with SD were randomized to receive MAS064D (n= 40) or a matching vehicle (n = 20). The primary study endpoint was investigators’ global assessment (IGA) score at day 28, compared with baseline. Secondary endpoints included: IGA score at day 14; investigators’ assessment of erythema and scaling; patients’ assessment of burning/stinging, pruritus and global response to MAS064D; resort to rescue medication; quality of life.

Results: Use of MAS064D for 4 weeks was associated with a higher percentage of success in the MAS064D group than in the vehicle group (~68% vs 11%, P < 0.0001). The effects of MAS064D were significantly better than those of vehicle for investigator-assessed erythema and scaling, and patients’ assessed pruritus and global response to MAS064D (P ≤ 0.01). No patient in the MAS064D
group required rescue medication, compared with two patients in the vehicle group. Four patients (two each in the MAS064D and vehicle groups) reported a total of six non-serious adverse events.

Conclusions: MAS064D appears to be an effective and well tolerated cream for the treatment of mild to moderate SD of the face. Further clinical evaluation of MAS064D in SD is warranted.

Update: Sebclair has launched as Promiseb Cream in the United States.

Sinclair Pharma: Sebclair

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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29 Reader Comments

  1. D says:

    Is this available yet in the US? I also travel to the UK and Europe from time to time, and it seems to indicate on their website that this could be available both over the counter and by prescription. Either way as I’m in London today I will try to see if I can find some as this would be very helpful for me.

  2. I don’t believe that it is available in the US yet, but would love to hear from someone if they do find it.

  3. Maria says:

    I would love to try it. I ask my family to look for it in Spain and they did not find it.

  4. Zodwa says:

    I would like to try it. It’s not available at the pharmacy where I buy my medicine in South Africa.

  5. Unfortunately this product is still very new. Would love to hear from people that have been able to find it and even better have tried it !

  6. liz g says:

    would love to know where to buy this in the uk,as my skin is so bad on my face please help.

  7. Sunil says:

    elidel not workin for me i want to try sebclair is it available in uk plz… anyone

  8. david says:

    SebClair is sold in US by Dr Reddy (

    for Europe here is an Italian website seller

    for Uk concact sinclair company

  9. Tom McCracken says:

    Please advise when Sebclair will be available for sale as a prescription product in the United States. Thank you.


  10. Apparently Dr. Reddy’s will be the exclusive marketer of Sebclair in the US. It was also announced in Sep 2007 that Dr. Reddy’s would market Sebclair under a new brand name. It was expected to be launched within a year.

    Sinclair Pharma plc announces Dr Reddy’s Laboratories, Inc. as Sebclair marketing partner in US

    If I find out anything more about this product I will post it here.


  11. It looks like Australians can easily get this prepartion via mail and pay via paypal.

    It appears to be called Atopiclair and is available from It is listed as Atopiclair Cream 40ml and is $49 including postage to anywhere in Australia.

    The web site claims a “new, non-steroidal cream that is designed to relieve the symptoms and signs of eczema (atopic dermatitis) and allergic dermatitis (contact dermatitis).”

    Going by the papers they cite on that page and the paper above both quoting MAS063DP (Atopiclair[TM]), and the fact that Otco Global is listed as the Australian distributor – I’d say that this is Sebclair.


  12. Eric says:

    So Atopiclair is the same as Sebclair then?

  13. Well based on my reading, yes it is the same thing. I haven’t found an official statement saying that it is, but according to my reasons above I’m pretty confident.

    If someone finds something more definitive than my detective work above, please do let us know.

  14. Mike says:

    ‘So Atopiclair is the same as Sebclair then?’

    I don’t think it is, Atopiclair is for those with Atopic Dermatitis and Sebclair is for those with Seborrheic Dermatitis.

  15. The active ingredient is marketed and targeted at both of these conditions.

  16. yousef says:

    I would like to try this product ,how can i get it in israel ?

  17. Margaux says:

    I have seborrheic dermatitis and was just given a brand new cream called: Promiseb put out by: Promius Pharma.
    It contains the exact active ingredients as your website de-
    scribes in Sebclair! I have no idea how much it is, but I’m sure it’s exspensive. It comes in 30g tubes. (I was given samples) I will let you know how it does.

  18. Thanks Margaux, I felt sure it would surface soon. Please do let us know how you get on.

    It looks like the Promiseb Prescribing Information is also available online on the Promiseb web site.

    I want to pronounce it Promise-b, but I guess because of “seb” in the name is would be said Promi-Seb …


  19. Charlie says:

    I was given some Sebclair and almost as soon as I used it the redness and itching died down, and although i still have some of the symptons, my skin is in the best condition it has been in a long time. Unfortunately I don’t know where you would be able to get this yourselves but when you do find it, try it!

  20. Eric says:

    So Sebclair = Atopiclair = Promiseb?

  21. Julie says:

    I asked my Dr. for samples of promiseb. I was given 2 VERY small tubes – nurse told by pharmacy rep it was enough to last 2 weeks. NO WAY. I used the 2 small tubes but did not feel I’d had enough to really test it out. I asked for an rx for a 3 mo. supply (cheapest way under our ins). I got 3 small tubes – expensive even with ins. I have so much trouble with seb derm (blessed with lots of rosacea flushing too). I really want to find a non steroid that works. I gave it 3 weeks on the next area of breakout and sadly, it did not work for me. When totally clear, I’m thinking of using up the rest kind of like a moisturizer on the areas I frequently have the seb derm and see if it can help prevent since, for me, it does not help cure.

    Best I’ve found so far is Desonate at night, Xolegel in the a.m.. When the red and inflamed seb derm has calmed to just the flaking, the Xolegel handles that well.






  23. david says:

    have used sebclair for past 3 weeks and found it to be really good,i usually apply am&pm plus some diprobase as a moisturiser.having had sd for the past 20 years this is the only cream thats actually happy customer.

  24. Anna says:

    I bought this on the internet when my beloved Boots Botanics Rice Bran and Honey moisturiser, the only effective thing I have ever used for my seb derm, was recently discontinued.

    So far it is working well, keeps the skin comfortable and pale. I would definitely recommend it. (I still have seb derm as other things I tried before finding this online had me tearing at my face after a few hours. Not willing to go back to steroids).

  25. Louis Hoo says:

    Please advise when Sebclair will be available for sale as a prescription product in Viet Nam??

    what’s different from Sebclair and Atopiclair?

  26. Laura says:

    I live in Australia and just purchased Sebuclair cheaply from dermacare direct. It ships worldwide. Promiseb seems to be the same thing however much more expensive. Atopiclair is not the same product. I will let you know how Sebulclaire goes… Sounds so good!

  27. Lisa says:

    I recently bought this cream from Dermacare Direct as I suffer with facial SD I have only been using it for a few days 3 times a day as instructed – Less if symptoms calm down a little. I have noticed that my skin is still a little red but not as flaky and sore, my skin is also not as itchy and bumpy. I’m hoping the more I use this, the more effective it will be with time. I read that this has anti-fungal and anti inflammatory properties in which is a main point for SD sufferers as this is what causes the itch and the horrific redness I was always using treatments from the doctors that contained ketaconzole and other things to battle SD to no avail (all steroid based) I’ll give it a few more days and report back!

  28. John O says:

    Have had Seb Derm for over 10 years, it was only controlled with Canisten HC. Started using Seclair two months ago. I can only say that it has changed my life. As soon as there is any sign of inflammation two or three days of Sebclair and SD is gone. The mouisteriser in the cream is excellent.

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