ROSIE: a new Rosacea Expert Group

Written by on July 19, 2010 in research foundation with 0 Comments

With this recent abstract we learn about a new group of International Rosacea Experts.

Up until now the best known group of rosacea experts was organised by the National Rosacea Society, and was referred to as the Rosacea Expert Committee.

The NRS Expert Committee over the years has been responsible for amongst others the 4 following landmark rosacea publications;

According to this new paper, it has proven difficult to achieve international consensus on therapy guidelines for rosacea.

Interestingly, one of the authors of this paper, Dr. Zoe Draelos, is also listed an author of Standard management options for rosacea and is additionally a member of the NRS Expert Committee itself, so I don’t see this new ROSIE expert group being in competition with, but complementing the NRS expert efforts.

The paper proposes extra emphasis on three prongs of patient education, skin care and drug and physical therapies. Further, the paper suggests that sub-type based treatments might not serve the patient best especially if more than one subtype is present.

The group seems to prefer a regime based on the signs and symptoms of rosacea rather than a subtype classification, but this doesn’t seem to be in conflict with the standard treatments for rosacea, which also seeks to classify symptoms in order to treat them.

Rosacea sufferers can only benefit from more experts getting together and proposing ways to best treat rosacea.

Regardless of what they have to say, you do have to admit that ROSIE is a cute name for a group associated with a red faced disease such as rosacea

Rosacea – global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group

J Eur Acad Dermatol Venereol., 2010 Jun 23, Elewski BE, Draelos Z, Dréno B, Jansen T, Layton A, Picardo M.

Background: The absence of specific histological or serological markers, the gaps in understanding the aetiology and pathophysiology of rosacea, and the broad diversity in its clinical manifestations has made it difficult to reach international consensus on therapy guidelines.

Objectives: The main objective was to highlight the global diversity in current thinking about rosacea pathophysiology, classification and medical features, under particular consideration of the relevance of the findings to optimization of therapy.

Methods: The article presents findings, proposals and conclusions reached by the ROSacea International Expert group (ROSIE), comprising European and US rosacea experts.

Results: New findings on pathogenesis provide a rationale for the development of novel therapies. Thus, recent findings suggest a central role of the antimicrobial peptide cathelicidin and its activator kallikrein-5 by eliciting an exacerbated response of the innate immune system. Cathelicidin/kallikrein-5 also provide a rationale for the effect of tetracyclines and azelaic acid against rosacea.

Clinically, the ROSIE group emphasized the need for a comprehensive therapy strategy – the triad of rosacea care – that integrates patient education including psychological and social aspects, skin care with dermo-cosmetics as well as drug- and physical therapies.

Classification of rosacea into stages or subgroups, with or without progression, remained controversial. However, the ROSIE group proposed that therapy decision making should be in accordance with a treatment algorithm based on the signs and symptoms of rosacea rather than on a prior classification.

Conclusion: The ROSIE group reviewed rosacea pathophysiology and medical features and the impact on patients and treatment options. The group suggested a rational, evidence-based approach to treatment for the various symptoms of the condition. In daily practice this approach might be more easily handled than prior subtype classification, in particular since patients often may show clinical features of more than one subtype at the same time.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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