ROSÉLIANE Anti-Redness Cream (SK5R on KLK5)

Written by on December 9, 2015 in Rosacea Topicals, What Causes Rosacea? with 4 Comments

A poster session at the 2015 San Francisco AAD meeting promotes the significant improvement in facial redness offered by the active called specific-kallikrein-5-regulator (SK5R). This ingredient is found a product called ROSÉLIANE Anti-Redness Cream, which is made by Uriage, who funded the trial that is described in the abstract presented.

It is interesting to see a topical being tested that claims to be able to address  cathelicidin LL-37 and kallikrein-5 (KLK5) expression, which is thought to lead to the inflammation associated with rosacea.

ROSÉLIANE Anti-Redness Cream Product Publicity

The product web site for ROSÉLIANE Anti-Redness Cream makes some claims about the active ingredients and the research behind them.

Restores and fortifies the immunological barrier

A new patent filed by the Uriage Dermatological Laboratories combines TLR2-Regul complex and SK5R complex (Specific-Kallikrein-5-Regulator) to regulate the activity of Kallikrein-5, a protease that causes inflammation and vascular problems, and provide highly effective soothing action.

ROSÉLIANE Anti-Redness Cream Ingredients

  • Uriage Thermal Water
  • Cerasterol-2F
  • SK5R Complex
  • TLR2-REGUL Complex
  • Combination of plants
  • Green pearlescent particles
  • Glycerine
  • Shea butter

AAD Poster Session

TLR-2, cathelicidin-LL37 and kallikrein-5 targeting in rosacea: In tubo, ex vivo and in vivo studies

JAAD Poster 1445, May 2015, Volume 72, Number 5, American Academy of Dermatology 73rd Annual Meeting, March 20-24, 2015, San Francisco, California.

Marius Anton Ionescu, MD, PhD, Dermatology Outpatient Clinic, University Hospital Saint Louis, Paris, France; Francine Joly, PhD, Sephrapharma, Puteaux, France; Elodie Bombard, PhD, Sephrapharma, Puteaux, France; Geraldine Robert, MBBCh, Laboratoires Dermatologiques d’Uriage, Neuilly sur Seine, France; Luc Lefeuvre, PharmD, Laboratoires Dermatologiques d’Uriage R&D, Neuilly sur Seine, France; Michel Bohbot, PharmD, PhD, Laboratoires Dermatologiques d’Uriage, Neuilly sur Seine, France

Background: Toll-like receptor 2 (TLR2) activation and antimicrobial peptides (AMP) up-regulation by Demodex species and by bacillus oleronius play an important role in rosacea physiopathology.

Post transductional changes of AMP cathelicidin LL-37 and kallikrein-5 (KLK5) expression lead to inflammation.

Objectives: To assess the inhibitor effect of specific-kallikrein-5-regulator (SK5R) on KLK5 in tubo, ex vivo, and in vivo in rosacea patients.

Materials and methods: In tubo assessment: enzymatic activity of KLK5 was assessed by incubating it with a chromogenic fluorescent substrate (Boc-Val-Pro-Arg). KLK5 inhibitor effect of the complex SK5R  (brown algae extract and Uriage thermal water) was assessed versus reference KLK inhibitor AEBSF.

  • Ex vivo assessment: normal human skin explants – untreated or treated by an O/W emulsion based on SK5R – were put in contact with Demodex chitin fragments (of 40-70 “m, in suspension), control untreated explants had no contact with chitin. Dosage of IL-8 and KLK5 expression were made by ELISA.
  • In vivo assessment: rosacea patients with no general or topical Rx were included in an open clinical trial using an O/W emulsion based on SK5R bid for 4 weeks. At baseline, week 2 (W2) and W4 were made: clinical examination, chromametry assessment of (parameter +a* – red in Lab* system) and photography. Scores were made for erythema, telangiectasias, roughness, sensations of ‘‘heat,’’ discomfort.

Results: In tubo: KLK5 was significantly decreased by AEBSF (by 98%) and by SK5R (by 68%).

  • Ex vivo: in untreated explants in contact with Demodex chitin, both IL-8 and KLK5 were significantly increased compared to control (by 30% and respectively by 58%). In SK5R-treated explants in contact with chitin, the expression of KLK5 increased by 8% compared to control, IL-8 by 10%.
  • In vivo: were included 40 female rosacea patients. The mean decrease of the chromametry parameter +a* was 9% at W4 compared to baseline. Skin roughness, diffuse facial erythema, discomfort and sensation of ‘‘heat’’ decreased significantly at W2 and W4.

Conclusions: In tubo tests showed an inhibition kallikrein-5, ex vivo study on SK5R- treated human skin in contact with Demodex chitin showed a decrease of kallikrein-5. In a clinical trial on 40 rosacea patients, an O/W emulsion based on SK5R applied bid for 4 weeks significantly improved facial erythema and rosacea symptoms.

Study Funded by Laboratoires Dermatologiques d’Uriage.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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4 Reader Comments

  1. David Pascoe says:

    comment via email.

    I’ve had rosacea since 2005′ and have battled to keep it under control, I have used lots of products and hints from the Internet, for the last 2 years I have been using sink cream, but lately I use vasaline on my forehead nose and cheeks at night and this seems to work for me ( well at the moment) I did use a tropical cream but found it burned and made it worse, and as for keeping out the sun, difficult I live I South Africa and there’s always sun !

    All in all I grin and bear it most of the time, make up makes it worse, so I tend not to use any, so me and my rosy face, face the day just as we are, I think the less you fuss over it, the better it becomes, so I have a rosy out look on life, a little sun kissed at times, but what the hell, lots of other people are a lot worse off than me and my rosacea, so I smile and just get on with life, zinc zaps those pimples sometimes, so my advice is wear your rosy glow with a big rosy smile and enjoy life !! “

  2. James says:

    Azelaic Acid also alters the expression of cathelicidin/KLK5. I tried a tube but unfortunately did nothing for me. Hopefully, this cream will work for me; and perhaps is more effective at inhibiting the protease activity. Could use some hope! I’m giving this a try for permanent redness/phymatous rosacea. Will update with results…

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