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A poster session at the 2015 San Francisco AAD meeting promotes the significant improvement in facial redness offered by the active called specific-kallikrein-5-regulator (SK5R). This ingredient is found a product called ROSÉLIANE Anti-Redness Cream, which is made by Uriage, who funded the trial that is described in the abstract presented.
It is interesting to see a topical being tested that claims to be able to address cathelicidin LL-37 and kallikrein-5 (KLK5) expression, which is thought to lead to the inflammation associated with rosacea.
ROSÉLIANE Anti-Redness Cream Product Publicity
The product web site for ROSÉLIANE Anti-Redness Cream makes some claims about the active ingredients and the research behind them.
Restores and fortifies the immunological barrier
A new patent filed by the Uriage Dermatological Laboratories combines TLR2-Regul complex and SK5R complex (Specific-Kallikrein-5-Regulator) to regulate the activity of Kallikrein-5, a protease that causes inflammation and vascular problems, and provide highly effective soothing action.
ROSÉLIANE Anti-Redness Cream Ingredients
- Uriage Thermal Water
- Cerasterol-2F
- SK5R Complex
- TLR2-REGUL Complex
- Combination of plants
- Green pearlescent particles
- Glycerine
- Shea butter
AAD Poster Session
TLR-2, cathelicidin-LL37 and kallikrein-5 targeting in rosacea: In tubo, ex vivo and in vivo studies
JAAD Poster 1445, May 2015, Volume 72, Number 5, American Academy of Dermatology 73rd Annual Meeting, March 20-24, 2015, San Francisco, California.
Marius Anton Ionescu, MD, PhD, Dermatology Outpatient Clinic, University Hospital Saint Louis, Paris, France; Francine Joly, PhD, Sephrapharma, Puteaux, France; Elodie Bombard, PhD, Sephrapharma, Puteaux, France; Geraldine Robert, MBBCh, Laboratoires Dermatologiques d’Uriage, Neuilly sur Seine, France; Luc Lefeuvre, PharmD, Laboratoires Dermatologiques d’Uriage R&D, Neuilly sur Seine, France; Michel Bohbot, PharmD, PhD, Laboratoires Dermatologiques d’Uriage, Neuilly sur Seine, France
Background: Toll-like receptor 2 (TLR2) activation and antimicrobial peptides (AMP) up-regulation by Demodex species and by bacillus oleronius play an important role in rosacea physiopathology.
Post transductional changes of AMP cathelicidin LL-37 and kallikrein-5 (KLK5) expression lead to inflammation.
Objectives: To assess the inhibitor effect of specific-kallikrein-5-regulator (SK5R) on KLK5 in tubo, ex vivo, and in vivo in rosacea patients.
Materials and methods: In tubo assessment: enzymatic activity of KLK5 was assessed by incubating it with a chromogenic fluorescent substrate (Boc-Val-Pro-Arg). KLK5 inhibitor effect of the complex SK5R (brown algae extract and Uriage thermal water) was assessed versus reference KLK inhibitor AEBSF.
- Ex vivo assessment: normal human skin explants – untreated or treated by an O/W emulsion based on SK5R – were put in contact with Demodex chitin fragments (of 40-70 “m, in suspension), control untreated explants had no contact with chitin. Dosage of IL-8 and KLK5 expression were made by ELISA.
- In vivo assessment: rosacea patients with no general or topical Rx were included in an open clinical trial using an O/W emulsion based on SK5R bid for 4 weeks. At baseline, week 2 (W2) and W4 were made: clinical examination, chromametry assessment of (parameter +a* – red in Lab* system) and photography. Scores were made for erythema, telangiectasias, roughness, sensations of ‘‘heat,’’ discomfort.
Results: In tubo: KLK5 was significantly decreased by AEBSF (by 98%) and by SK5R (by 68%).
- Ex vivo: in untreated explants in contact with Demodex chitin, both IL-8 and KLK5 were significantly increased compared to control (by 30% and respectively by 58%). In SK5R-treated explants in contact with chitin, the expression of KLK5 increased by 8% compared to control, IL-8 by 10%.
- In vivo: were included 40 female rosacea patients. The mean decrease of the chromametry parameter +a* was 9% at W4 compared to baseline. Skin roughness, diffuse facial erythema, discomfort and sensation of ‘‘heat’’ decreased significantly at W2 and W4.
Conclusions: In tubo tests showed an inhibition kallikrein-5, ex vivo study on SK5R- treated human skin in contact with Demodex chitin showed a decrease of kallikrein-5. In a clinical trial on 40 rosacea patients, an O/W emulsion based on SK5R applied bid for 4 weeks significantly improved facial erythema and rosacea symptoms.
Study Funded by Laboratoires Dermatologiques d’Uriage.
comment via email.
“Hi
I’ve had rosacea since 2005′ and have battled to keep it under control, I have used lots of products and hints from the Internet, for the last 2 years I have been using sink cream, but lately I use vasaline on my forehead nose and cheeks at night and this seems to work for me ( well at the moment) I did use a tropical cream but found it burned and made it worse, and as for keeping out the sun, difficult I live I South Africa and there’s always sun !
All in all I grin and bear it most of the time, make up makes it worse, so I tend not to use any, so me and my rosy face, face the day just as we are, I think the less you fuss over it, the better it becomes, so I have a rosy out look on life, a little sun kissed at times, but what the hell, lots of other people are a lot worse off than me and my rosacea, so I smile and just get on with life, zinc zaps those pimples sometimes, so my advice is wear your rosy glow with a big rosy smile and enjoy life !! “
Why do you post this irrelevant comment under the article?
Because this is how this person reached out for help – by replying to my email on this article. Quite often people can’t work out how to post in the most appropriate location – but still would love a response.
Azelaic Acid also alters the expression of cathelicidin/KLK5. I tried a tube but unfortunately did nothing for me. Hopefully, this cream will work for me; and perhaps is more effective at inhibiting the protease activity. Could use some hope! I’m giving this a try for permanent redness/phymatous rosacea. Will update with results…