Rosacea sufferers, if you have gut symptoms, see a gastroenterologist!

Written by on March 25, 2020 in IBD, SIBO, What Causes Rosacea? with 0 Comments

An analysis of the conditions that are found more frequently amongst rosacea sufferers has confirmed irritable bowl syndrome associated symptoms as more likely. In particular Crohns Disease and Ulcerative Colitis are found in statistically significantly more rosacea sufferers than the general population.

What might this mean for your gut symptoms ?, well the researchers say that there is enough information to say that if you have chronic abdominal pain, prolonged diarrhoea, or bloody stools then see a gastroenterologist as you might have an increased risk of irritable bowel disease.

What do we know about Rosacea and IBD?

  • Rosacea patients have a significantly higher SIBO prevalence than controls.
  • Eradication of SIBO can induce an almost complete regression of cutaneous lesions for IBD sufferers.

So if you have been diagnosed with rosacea, be aware that if you have gut symptoms a consultation with a gut specialist is probably worthwhile.

Article Abstract

Association of rosacea with inflammatory bowel disease

Rosacea has been reported with several systemic comorbidities, but its relationship with inflammatory bowel disease (IBD) is unclear. Thus, our objective is to conduct a meta-analysis on the association of rosacea with IBD. We conduct a meta-analysis and searched MEDLINE, CENTRAL, and Embase databases for case-controlled and cohort studies that assessed the association of rosacea with IBD from inception to July 2nd, 2018. Two authors independently selected studies, extracted data, and assessed the risk of bias of included studies. Disagreement was resolved by discussion. We performed random effects model meta-analysis to obtain the pooled risk estimates for Crohn disease (CD) and ulcerative colitis (UC) in patients with rosacea. We included three case-control and three cohort studies. The risk of bias of included studies was generally low.

The meta-analysis on case-control studies showed marginally increased odds of CD (pooled odds ratio (OR) 1.30, 95% confidence interval (CI) 0.99– 1.69) and a significantly increased odds of UC (pooled OR 1.64, 95% CI 1.43–1.89) in patients with rosacea.

The meta-analysis on cohort studies demonstrated significant increased risk of CD (pooled hazard ratio (HR) 1.58, 95% CI 1.14–2.20) and UC (pooled HR 1.18, 95% CI 1.01–1.37) in patients with rosacea.

The evidence indicates an association of rosacea with IBD. If patients with rosacea suffer from prolonged abdominal pain, diarrhea, and bloody stool, referral to gastroenterologists may be considered.

Our study indicates patients with rosacea are associated with an increase in prevalent CD and UC. The evidence from case-control studies indicates 1.30-fold odds of prevalent CD and 1.64-fold odds of prevalent UC in rosacea patients when compared to controls

On the other hand, the evidence from cohort studies reveals a 1.58-fold risk of incident CD and a 1.18-fold risk of incident UC in rosacea patients when compared to controls

A significantly increased prevalence of SIBO has been found in patients with rosacea. Remarkably higher SIBO has been observed in both CD and UC patients, and eradication of SIBO substantially improved clinical symptoms of IBD.[33,64,65] Higher SIBO has also been found in rosacea patients, and eradication of SIBO led to complete resolution of rosacea and maintained remission

In conclusion, our study demonstrates a modest association of rosacea with prevalent and incident IBD. Conversely, another study has shown that IBD is associated with an increase in rosacea. Putting together the evidence, rosacea and IBD are related to each other. When rosacea patients suffer from chronic abdominal pain, prolonged diarrhea, and bloody stool, the possibility of comorbid IBD should be considered.

Abbreviations:

  • BTNL2 = butyrophilin-like 2,
  • CD = Crohn disease,
  • CI = confidence interval,
  • GST = glutathione S-transferases,
  • HLA = human leukocyte antigen,
  • HR = hazard ratio,
  • IBD = inflammatory bowel disease,
  • ICD = International Classification of Disease,
  • MOOSE = Meta-analysis of Observational Studies in Epidemiology,
  • NOS = Newcastle-Ottawa Scale,
  • OR = odds ratio,
  • SIBO = small intestinal bacterial overgrowth,
  • UC = ulcerative colitis.
  • ST = glutathione S-transferases

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Read more about: IBD, SIBO, What Causes Rosacea?

About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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