Rosacea means drier, redder and sweaty skin

Written by on July 8, 2017 in blushing, flushing with 0 Comments

This paper is full of technical terms, but contains some simply stated outcome for rosacea suffers. Researchers can see that rosacea sufferers have more water loss from the surface of their skin (i.e. their skin gets drier and potentially more irritated) , greater dilation of blood vessels and more rapid sweating than the general population.

This research is along similar lines to Dr. Drummond’s interest in Rosacea and the Sympathetic Nervous System.

Augmented supraorbital skin sympathetic nerve activity responses to symptom trigger events in rosacea patients

J Neurophysiol 114: 1530–1537, 2015.
Metzler-Wilson K, Toma K, Sammons DL, Mann S, Jurovcik AJ, Demidova O, Wilson TE.

Facial flushing in rosacea is often induced by trigger events. However, trigger causation mechanisms are currently unclear. This study tested the central hypothesis that rosacea causes sympathetic and axon reflex-mediated alterations resulting in trigger-induced symptomatology.

Twenty rosacea patients and age/sex-matched controls participated in one or a combination of symptom triggering stressors.

In protocol 1, forehead skin sympathetic nerve activity (SSNA; supraorbital microneurography) was measured during sympathoexcitatory mental (2-min serial subtraction of novel numbers) and physical (2-min isometric handgrip) stress.

In protocol 2, forehead skin blood flow (laser-Doppler flowmetry) and transepithelial water loss/sweat rate (capacitance hygrometry) were measured during sympathoexcitatory heat stress (whole body heating by perfusing 50°C water through a tube-lined suit).

In protocol 3, cheek, forehead, forearm, and palm skin blood flow were measured during nonpainful local heating to induce axon reflex vasodilation. Heart rate (HR) and mean arterial pressure (MAP) were recorded via finger photoplethysmography to calculate cutaneous vascular conductance (CVC; flux·100/MAP).

Higher patient transepithelial water loss was observed (rosacea 0.20 ± 0.02 vs. control 0.10 ± 0.01 mg·cm(-2)·min(-1), P < 0.05). HR and MAP changes were not different between groups during sympathoexcitatory stressors or local heating.

SSNA during early mental (32 ± 9 and 9 ± 4% increase) and physical (25 ± 4 and 5 ± 1% increase, rosacea and controls, respectively) stress was augmented in rosacea (both P < 0.05).

Heat stress induced more rapid sweating and cutaneous vasodilation onset in rosacea compared with controls. No axon reflex vasodilation differences were observed between groups.

These data indicate that rosacea affects SSNA and that hyperresponsiveness to trigger events appears to have a sympathetic component.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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