Rhofade User Reviews


Allergan’s Oxymetazoline based cream, Rhofade (oxymetazoline hydrochloride cream 1%) – for the treatment of the redness of rosacea is now generally available. Does it work to effectively and safely reduce the redness of rosacea? You have come to the right page to find out.

Some Oxymetazoline History

For rosacea sufferers it has been a long development cycle, the story starting with the emergence of Oxymetazoline as a rosacea active in 2007. Aspect Pharmaceuticals, Vicept Therapeutics and finally Allergan were owners of the intellectual property behind Rhofade, which first came to our attention through a 2005 patent (20050165079) by Shanler and Ondo.

So it has been a very long time since rosacea sufferers first starting hearing about the active in products like Afrin being a possible treatment for the redness of rosacea.

What is Rhofade?

Rhofade is being promoted as ;

The first and only α 1A adrenoceptor agonist approved for persistent facial erythema associated with rosacea in adults.

This is sales-speak as Mirvaso has been available for several years now and is similarly promoted as the only `α adrenoceptor agonist’.

Is Rhofade the same as Mirvaso?

If you were to solely read internet reviews of Mirvaso you could be forgiven for thinking that Mirvaso has been a very problematic product for Galderma (see Mirvaso Reviews). The adverse reaction rate to Mirvaso during the clinical trials before approval does not appear to be borne out by subsequent internet respondents. It isn’t clear why this appears to be the case – more frequent adverse reactions experienced outside the tightly controlled and monitored environment of the blinded clinical trials.

Every rosacea sufferer looking for relief from their red face is hoping that as claimed, Rhofade really will prove to be a “topical treatment of persistent facial erythema associated with rosacea in adults.”

Rhofade – the successor to Mirvaso?

It isn’t yet clear what Allergan have been able to do with the commonly available active ingredient Oxymetazoline to package it as palatable to the sensitive skin of rosacea sufferers. One clue appears to be the usage of “more selective for α1D-adrenoceptors are less prone to induce receptor desensitization than are α1A– or α1B-agonists” as found in the off the shelf products”. Although we know now that Rhofade is being promoted as a α 1A adrenoceptor agonist.

Certainly we are all hoping that Rhofade will become a well liked and tolerated rosacea treatment, that is true to the 1 year, only 3% adverse reaction rate generally experienced during the Rhofade clinical trials.

How much improvement will I see?

It is worth tempering your hopes for success with Rhofade with the published clinical trial data that shows that ;

Will RHOFADE work for me ?

Going on the published clinical data, basically one in 6 or 7 users of RHOFADE will have a 2-grade improvement in their facial redness, typically for 12 hours, and continuing for 29 once-daily uses.

Rhofade Reviews

So finally, rosacea sufferers are able to fill a prescription for Rhofade. Please let your fellow rosacea sufferes know what you think of Rhofade, we are especially interested in any rebound redness that your might experiences.

Please leave a comment below. Thanks!

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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181 Reader Comments

  1. Luke says:

    I had a terrible experience with Rhofade. I went to a dermatologist because of mild symptoms of rosacea. I used Rhofade for 4 days, and it made symptoms 10 times worse. I looked like I had a bad sunburn and pimples. My skin was also dry and burning.
    I stopped using it and I bought Eucerin Sensitive Skin Redness Relief Soothing Night Cream, and Eucerin Redness Relief Cleanser from Walgreens. They are helping. Now my skin is just a little pink in some spots.

    • barbarelli says:

      I have been given prescription creams in the past which have been too harsh for me. i purchased Bioderma micelar water to cleanse my sensitive skin and Bioderma sensibo cream to sooth and moisturise I also use Bioderma BB cream which is tinted and suits all skin shades it is great and even my GP is impressed these were recommended by my Dermatologist I spent a fortune on different lotions potions like we all have I expect . these ones are very gentle for my skin and i saw a great improvement and reduction in redness . I also went on a course of Doxycycline which helped enormously Dermalex cream I use when I get some ‘lumps’ which dries them up without being too harsh . but the BB cream has enabled me to have confidence in covering the redness up and all the above last for a long time. they have sunscreen protection in them as well.

      I cant use normal sunscreen potions on my face I wish they could find a ‘cure’ for us as quite often it is sore as well as unsightly , but with my Bioderma I am a lot better and skin feels comfortable try and get a sample before you spend your money .m yskin was so bad at one time it was very swollen and inflamed. and painful now I recieve compliments . but only with the bb cream on..to be honest. as will never be perfect again i now stay away from spicy food & chinese food (MSG) and I have had no major outbreaks just a few small bumps now and again and sometimes a mils redness around my nose for some reason good luck to us all

  2. Juanita Holland says:

    Sadly, I must concur with other posters: you hope for relief and end up disappointed. I was given several samples of Rhofade on Wednesday, August 23rd. I applied a small size on Thursday, August 24th. It is now Friday, September 1st, and I won’t use the remainder of my samples. The first day (Thursday), the redness diminished completely. That sunburn look was gone! It was still gone on Friday. But by Saturday, a little of the redness had returned, and my skin looked oily. I don’t have oily skin. I continued to use Rhofade, but the redness was returning, and I still looked oily. Now, as Luke posted, I’ve got small bumps as if I had pimples (I don’t get them), and I look sunburned. HOWEVER: I have never experienced the burning or itching that others said they experienced. Just the bumps/tiny pimple breakout (forehead, between the brows, cheeks). I’m several years shy of hitting 50, and my rosacea only showed up the past ten years, so I haven’t been completely self-conscious about it. The Rhofade was my first ever attempt at trying to diminish the redness.

    • Heather Miller says:

      I am sorry this hasn’t worked for you. Like you, my Rosacea did not appear until my 40’s. I use Soolantra to get rid of the pimple like bumps and it works very well, you might want to ask for a sample. I do have great success with rhofade (it is my “hero”) and am so sorry it didn’t work for you. I hope you find something that works!

      • Juanita Holland says:

        Hello, Heather. It is exciting to see that Rhofade CAN be a miracle, but I’d love to know why success is in the minority. Future luck to you. Thanks for the tip on Soolantra.

    • Christy says:

      Exact same thing happened to me! Same sympoms same timeline but, i also have burning and itching!

  3. LeAnn says:

    Ok. I have been dealing with rosacea for just a couple of years and have been using Metro gel with very little results. My dermatologist gave me some Rhofade samples 3 days ago. I applied this cream for 3 days and I am about to crawl out of my skin. I have taken 2 doses of Benadryl today to try and calm the extreme itchiness! I also now have bumps all over my face that I never had before. I’m so disappointed!! I will never use this stuff again!

  4. Mike says:

    Rhofade sucks just like every other rosacea medication. The chances that it will work or under 15%, and the chances it will actually make your skin substantially worse are at least 85%. Not worth it. I took it and thought it was a miracle the first day, but my skin flared up when it wore off and it took me about a month to recover. My skin was on fire for about a month straight, all day everyday, after a single application. Not even close to a success. I think it’s an absolute scandal how incompetent the medical industry has been on rosacea, considering it’s 2017. They should have this figured out by now. Decades ago, actually. It’s scandalous that they haven’t

    • Heather Miller says:

      Sosorry it didn’t work for you. It has been a miracle for me. I have used it everyday since the beginning of May. I do hope you find something that works.

      • BB says:

        Hi Heather

        Can you describe your skin as best you can or point to a image which is similar to you regarding skin.

        I have diffuse redness on my cheeks only but it’s not itchy or anything else. Only has occasional flush with heat or stress.

        I haven’t any broken capillaries only showing redness.

        So you haven’t had any rebound effects?

        If your skin type is similar then I might try it when it becomes available in Europe.

        Thanks for any info

        • Heather Miller says:

          Your skin sounds about like mine. I had redness in cheeks, chin and nose (always asked if I got sunburned). I didn’t have any capillaries showing. If I could find a way to post a pic here I would….I wasn’t itchy or anything either. This cream definitely helps me. My nose is still a tad red at times, and under influence of extreme stressors (heat, alcohol) I did get a little red again, but on a daily basis, I can be makeup free

          • BB says:

            Thanks for the reply heather

            That’s great that it’s working for you. That gives me some hope that it may work for me also.

            The rebound stories have put me off a little not sure why some get rebound and some don’t I guess there is many different factors with skin.

            How long does rhofade last for when applying, is it roughly 12 hours and how long does it take to notice effects. Do you gradually return to normal redness after it wears off.

            Have you heard of the condition called kprf. It is very similar to rosacea. Type “kprf skin” in Google images. It looks similar to mine. Does your skin look similar to it?

            Most dermatologists haven’t heard of this kprf and I only recently heard about it on rosacea forum. I presumed I had rosacea but looks more like this kprf.

            Hopefully rhofade will work with kprf also.

            Thanks again for listening

          • Heather Miller says:

            Mine looks similar to the Krpf also, but it’s hard to tell from photos. The Rhifade worked within an hour and lasts all day. I have also noticed less redness in the mornings before I put it on. When I first sratrred using it my cheeks would not really tingle but fell “odd” but that sensation subsided after a few days. If you have acne like bumps with your redness, you could trt soolantra. That cleared my bumps up quickly. Good luck.

          • BB says:

            Thanks for the info heather. Much appreciated.

            Keep us updated on your progress.

    • pete says:

      Totally agree Milke , The Rosacea treatment industry is nothing but a farce , Its 2017 and they still cant treat redness – All involved should be ashamed of themselves .

    • Mike, , I live in Australia so US products are not available here. We have Rosex which does nothing or antibiotics which do not work. I agree with your sentiments. What did help a lot with my rosacea (which I’ve had since a teenager and now am 73) was 50mg Voltaren tablets prescribed for a swollen and painful knee after a fall. This medication drastically reduced my redness, but sadly is not safe for continued use as it has dangerous side effects. However, it obviously shows that my rosacea is an inflammatory condition. For several years I’ve been using Hydrozole cream (1% cortisol) every night which usually prevents outbreaks of pustules. If pustules do come, I use Animine cream at night (2.5mg benzalkonium chloride, 30 mg lignocaine hydrochloride and 200 mg zinc oxide). It is like a very thick calamine lotion. This dries up pustules effectively in 2 or 3 days. Although I’m old, my skin is not dry, especially not my nose which is where most pustules erupt. Dermatologists do not have a clue and I’ve just worked out my own treatment by trial and error. Nowhere have I seen that rosacea is an inflammatory condition, also many are diagnosed with rosacea who in fact just have dry, sensitive skin – something completely different. Good luck with yours and perhaps my suggestions might help.

  5. Ann says:

    I started using this product and I have super sensitive skin with zero inflammation from the product. Too early to know how it works but will post again in 30 days. Just from using the product for the last couple days and looking at the review post I am not sure if some of these post are a sham. I have super sensitive red skin and I’m not oily or broken out. Hmm! I always try to ready the negative before the postive but thinking this is far fetched.

    • Katherine says:

      Ann. I have super sensitive skin too. This product worked wonders for me for 2-3 days. But then I had a horrible reaction that took over a week to go away. Closer to 2 weeks. I assure you. These comments are not a sham. I’ve been following it for a bit and it seems like very few people have success. My problem is I’m sensitive to alcohol (mostly figured it out after the fact) and this product had 4 types of alcohols which aren’t the best for your skin anyway.

      • Lynne says:

        I had a similar experience.. looked great for couple days then one morning.. I was bright red and felt swollen.. I’m very sad cause I thought I finally found something to help me

    • Toni says:

      I don’t know that this is far-fetched. I just looked up this Thread about rhofade. I used it for 3 Days samples for my dermatologist. I woke up in the middle of the night and my face was burning so bad and it was swollen it felt like a really bad sunburn. I took pictures of it. I took pictures because I was so confused. My dermatologist told me I should buy this cream because it doesn’t give you a rebound redness. I was using mirvaso and actually that wasn’t as bad as what I experienced with the real fade. I will say I did not use the mirvaso every single day. But definitely could mean I’m just as sensitive to mirvaso I’m glad you’re doing well. The metronidazole works the best for me.

  6. Patty says:

    Has anyone tried Finacea? I got a prescription from my Dr. along with a sample of Rhofade. But I don’t know if I want to try the Rhofade with all the problems I am reading.

    • Susan says:

      Hi Patty. Finacea and Rhofade do two different things. Finacea is used to basically kill bacteria on your skin that leads to some Rosacea symptoms (pimples, bumps, etc…) The Rhofade is to dull or temporarily eliminate the redness on your face by constricting blood vessels. I’m sure I’m not the only one who uses a multi-prong/medication attack for their rosacea, so I basically use both of these during the day and Soolantra at night to help control and treat my Rosacea. I’ve had zero problems with any of the meds. The only one that did bad things for me was Mirvaso. If the flushing/redness on your face is something that makes you unhappy (mine sure does) then it may be worth trying the Rhofade to see if it’s effective for you. I think all Rosacea sufferers are constantly trying different things to find the right combo to help their unique version of this shit condition. Hope this helps!

      • Irene says:

        Hi Susan I am using same combo I am 57 and my rosacea was getting worse as the years go by. Used Finacea then stopped also taking 40 mg of doxy which seems to be helping tremendously my face was red all over now it is just red around my nose not too bad. Just got some rhofade will post my results in a few days only going to try it on the red places not all over hope it works!

  7. V says:

    I had very mild redness and was surprised when my dermatologist during a routine check-up diagnosed me with rosacea. He gave me a few rhofade samples. I only applied it once and discontinued because of weird tingling sensations all over my face. In about two days after that my face turned red and was covered with tiny pimples. I’ve never had those before. It’s been a week since and my face is slightly less red and no more pimples but overall it’s still much worse than before rhofade. I’ve never had any reaction to alcohol until then either but now a single drink makes my face red. I reported my case to FDA and will be looking for a different dermatologist. I think it’s totally irresponsible to give out samples of medication that can cause such lasting damaging effects. Hopefully, someone will launch a class action suit against Allergan.

  8. Susan says:

    I switched from Mirvaso to Rhofade when it first came out and it has been amazing for me. Mirvaso was a complete nightmare. Yes it got rid of my redness, but once the medication wore off it came roaring back 100 times worse than before. It became a vicious circle and on days when I didn’t use the Mirvaso my redness was horrible. I haven’t remotely had that problem with Rhofade. It takes away redness much more naturally than Mirvaso and I don’t have that horrible flare up at the end of the day caused by the medication wearing off. I’ve actually seen my redness lessen over time now that my face isn’t dealing with the medication boomerang effect. I’ve been dealing with Rosacea for about 20 years now and the combo of Rhofade and Soolantra have helped me get better control of my symptoms. Now if someone would please just find a cure so none of us have to ever deal with this again I’d be very grateful

    • Mike says:

      There ain’t no cure coming – don’t hold your breath. It’s nearly 2018 and they haven’t even managed to find A SINGLE EFFECTIVE TREATMENT for rosacea that makes life manageable – not one. The odds of them finding a cure in the next 20 years are 0. There’s a 0% chance. I think, realistically, we won’t have any treatments that work even poorly until 2050 at the earliest (right now we dont even have medications that work poorly – they just ruin lives), and I doubt there will ever be a cure. But if there is, it won’t be for another century or two.

      Rosacea is one of the only conditions where you’re no better off getting it in 2017 than you would’ve been if you got it in the year 1500 BC. There are a tiny number of conditions that meet that criteria, and rosacea is certainly one of them.

      In other words, there’s been no advancement in our ability to treat/manage/cure rosacea whatsoever from the moment the first homosapiens walked the earth to present day. None. Zilch. Nada. We’re in the same position with regards to treating/managing rosacea today as we were 20,000 years ago. Just no progress whatsoever, on any dimension. You can’t say that about 99.99% of health conditions. It’s a remarkable feat

      • christopher says:

        Everyone with pustules and bumps of rosacea should be on isotretinoin low dose 10mg two or three times a week Its the only thing that controls my roscaea
        New Zealand dermatologist Marius Rademaker has published papers on this treatment

  9. Val says:

    I seem to have a middle of the road experience. It’s not great but provides some improvement. I’ve haven’t had any adverse reactions. Mirvaso was a disaster for me, exactly the same experience as others, worked great for a day or two, but then my face became nuclear to the point where people were concerned about my well being, and skin was in general much worse when not using Mirvaso.

    • Bill says:

      Of all the prescription creams I have tried, what actually works best for me is a moisturizer lotion called CeraVe
      Renewing SA Lotion

  10. Patti says:

    I I went to the dermatologist and got samples and RX for Rhofade for my mild rosacea. After using it for 3 days, I started noticing a lot of pimples popping up on my nose and cheeks. Also my skin was burning and itching very badly! My face was flushed and a little swollen. It was so painful I quit using it. It has only been 2 days and my face is still red, flushed and broken out and still itches. The burning is better after using a moisturizer. I thought maybe I was just having a reaction from it, but it looks like a lot of people are having the same issues with it. I have tried a lot of rosacea medications and have never had such bad side effects as these.

  11. Comment from Ellen.

    “It’s not on my Rx formulary and I was quoted $488 for a tube! Insane.”

  12. Comment from Beverly.

    “very costly, $750 in the USA and insurance does not cover this.”

  13. James says:

    I have tried: Cortisteriods, Protopic, Rhofade, Elidel, Soolantra, Minocycline, Eucrisa and the most relief I have ever received is with

    1) Collidial Oatmeal 2%
    2) Cerve (sp ?) Lotion

    I have rosacea and atopic dermatitis, Rhofade lacked any efficacy for me.

  14. Angela says:

    Tried on/off for a few weeks. Had to stop using…made my skin worse, no breakout…just really really red. Also felt like it was burning after first applying.

    • Cort says:

      I just started it on Tuesday and I am having a similar reaction. Burns for a minute or two after applying and I feel my face is a lot redder than before. Is there anything that you have found that works for you? Mirvaso worked very well when applied but did have rebound flushing.

  15. Tim says:

    I went to my dermatologist last week and she recommended Rhofade. I had never heard of it, but thought it could not be that bad as it was just a cream. My Rx did not cover it, but I was able to pick it up for $50 with an online coupon from Rhofade. I put a pea amount on my face as directed 2 days ago and my face has been bright red and burning since then. It is by far the worst that it has ever been even on my worst red face day. I will not put another dose on my face at this point and am out $50. Very disappointing. I was hoping to read some reviews that it improved after a few days, but it does not seem to look that way.

    • Vanessa says:

      I had a similar experience. Both my Father and Brother have had the redness for years. My brothers grow worse and the “spidery veins” on his face became extremely evident. He is twelve years older than me. I am just over 50 and mine has started to become “brighter red”. I wanted to head off the issue with the prominent veins in my face. The dermatologist gave me a script for Rhofade in December. Suprisingly it was covered by my insurance. I have been disappointed with the results since using it. The redness only actually increased. I did not have an issue with the bumps or pimples. I have discontinued use. I am glad that I can cover the redness with my make up, but on a no make up day, I hate looking into the mirror.

  16. Allan Thomas says:

    IPL works amazing well. I dare say I am cured of Red Flair ups and tiny spider veins.https://www.rosacea.org/rr/2005/summer/article_1.php

  17. Barbara says:

    Anxious to try it. The PI says it’s successful in 18% of users. That’s not very promising, but hopeful that I am in the 18%. Cash pay price is $500. My insurance copay was $25 and I was able to use the company co-pay card and brought my copay down to $0. Picked it up tonight. I’ll let you know my results.

  18. My government insurance will not allow me to buy Rhofade. If I purchase it on my own through Walmart they quoted me just under $300 for a small tube. Needless to say, I did not get it.

  19. Paula Couch says:

    I have been using Rhofade since early October. I have samples from my dermatologist. I have been very happy with how well it works on my almost constant facial redness. I was diagnosed with Rosacea 22 years ago. It was reasonably well controlled until about 3 years ago. My dermatologist introduced me to Soolantra earlier this year. I appreciate using both. I’m 66. My insurance requires prior authorization for Rhofade. Maybe I had better get my doctor to get that done before the end of the year and hopefully get a 90 day prescription through mail-order. That might last me most of 2018.

  20. Elizabeth says:

    Similar to my experience with Soolantra, a few days use of Rhofade resulted in a terrible flare up for me.

    I typically have slight redness on my cheeks and a bit worse on my nose. I have not had any pimples since I started minocyclin daily. I use Paula Begoun products to cleanse, tone and moisturize my skin. Occasionally I use Avar Green on affected area.

    Within a couple of days using Rhofade I had flaming red cheeks and nose and both were covered in pimples. I even got pimples on my forehead which I’ve never had before. Once I realized the effect, I stopped the Rhofade. Unfortunately my face got worse before better. The pimples lasted almost two weeks. As it wound down, my cheeks and nose were cracked, peeling and itchy.

    I’m done trying new products. Back to my simple routine.

  21. Alysann B Whitley says:

    I just started using Rhofade, and I’ve never had a reaction this bad. I used it for a few days but I had some added redness and tingling symptoms. I stopped taking it until I was out of school (only 2 days of classes left). After classes I took it again. It worked the first few days, but it got worse. So much worse. I haven’t taken Rhofade in 4 days and the symptoms keep getting worse. Whole room is hot. Burning. Tingling. Red all the time. The pain is so intense 🙁 disappointed

  22. Stephanie Perry says:

    I was hopeful that Rhofade would work for me after the redness on my face practically went away after the first application. However, the second and third day I had a little redness showing though, and I began breaking out with small iitchy pimples where I had applied the cream. By day 4 I felt my skin was redder than before I had started the Rhofade, and I had burning and itching with little bumps all over, as if I was having an allergic reaction. I stopped using the Rhofade cream on day 5, because the itching, burning, and redness had gotten so bad. It has been 3 days since I last applied the Rhofade, and I still look and feel like I’m having an allergic reaction, covered in little itchy bumps, and extremely red. I wish I never tried the Rhofade because it’s made my skin look so much worse than it ever was before using the product. I am really hoping the itching and bumps will subside soon, but I haven’t had any improvement yet.

    • Juanita says:

      It’s almost like we’ve traumatized our skin, by sampling Rhofade. Because (for me, at least), it took over a month for my skin to return to normal. Not sure about how others fared on here. Good luck to you.

  23. Daniel says:

    I was prescribed Rhofade by my derm. I applied it on the first day they gave it to me. On the first day I applied it, I saw results within the first 30 minutes which was quite impressive but I didn’t want to get too excited. So the first day was great. On the second day, I didn’t really see any results. Waking up on the third day in the morning being that I apply it in the morning and on the night, my face was full of weird looking bumps. I guess I got an allergic reaction. But I kept applying to see if maybe by any chance it was something else, although I had never had these weird looking bumps on my skin. So on the fifth day I stopped using it and I called my derm and she told me to go and see her so that she may see what she can do. She gave me these small samples of this steroid cream which help take off the bumps. So unfortunately it didn’t work for me. The derm has giving me Mirvaso and I’m getting mixed results. One cheek gets very red while the other one is much clearer.

  24. Regina F. says:

    Hello! I’ve been reading your comments and I’m literally amazed at what some of you are experiencing and what I sort of am with Rhofade.

    My Rosacea started in my early 40’s but I didn’t seek help until I saw my family doctor a year ago. My rosacea flares with a host of things: heat, foods, medicines, what have you. I have very sensitive skin. I don’t wear make-up, drink alcohol. I have a host of autoimmune diseases along with muscular dystrophy. When the rosacea first started it was on my right cheek now it has spread to the left, chin, and nose. When my family doctor examined me she saw the capillaries showing.

    When I’m in a flare, I feel so hot and my face feels tight and like I was burnt.

    I saw my new dermatologist on Thursday. Hubs and I were not pleased. He did not explain anything or give me information. He was only in the room five minutes! He gave us samples of this and and called in a prescription for it – actually pushed a new pharmacy on us! We decided I’ll not be going back.

    I started the Rhofade but didn’t notice any difference. When I applied it, I noticed pain immediately. I know now that is a side effect after researching. I also believe I have a pimple that started inside my nose today that wasn’t there until I started this cream. What about headaches? Anyone else experience this? The Rhofade also didn’t clear the rosacea. It would last four hours give or take. Oh, and when I was reading the information about this medicine on the web, it said if you are taking a beta blocker, you shouldn’t be taking this! Well I am! I’m not going to continue this medicine for several reasons.

  25. Rebecca Webb says:

    Began using Rhofade three days ago. Worked wonderful on the very first application…I actually had pretty, pale skin and felt like I looked “normal” for the first time since I can remember. Now, three days later, my skin is considerably more red, I have pimple-like bumps on my face, my skin burns, and I have a rash all along my midsection. Has anyone else gotten a rash away from the application site? I wonder if I keep trying Rhofade…how long after application before I can apply moisturizer and my makeup? Anyone else tried Oracea? I was prescribed this also but have not started it yet…

    • Teri says:

      I leave the Rhofade on for about 5 minutes before I apply my makeup. Also, I sometimes put it on at night before I go to bed. Then I put just a dot on my areas of concern, and it has worked beautifully.

    • Teri says:

      I tried Oracea, and was not as happy with the results as I have been with Rhofade. Try putting it on at night, then just a light application in the morning.

  26. Cindy says:

    I had used Mirvaso for about a year with great success. (Mirvaso in the morning, Sootantra in the evenings). My dermatologist recommended Rhofade a few months ago as another option with longer duration against redness. Rhofade has been everything my dermatologist stated. My face is completely clear of redness. However, I get terrible headaches from the product and sometimes my face feels slightly numb and tight. It works great, but the headaches are just too much. I’ve gone back to using Mirvaso and Soolantra.

    • bb says:

      Hi Cindy

      Can you describe your redness. Do you only get it on your cheeks and does it flush with heat etc. Is it kprf?

      It gives me a bit of hope when hear good stories like yours that it works.

      So you have had no rebound redness with mirvaso or rhofade? Do you use it everyday.

      Rhofade still not available in Europe here yet. Still scared to try mirvaso because of all the horrible rebound stories.

      Thanks for any info

  27. Chloe says:

    I started using Rhofade last week and it seemed like a miracle at first but then it started working off and on sometimes it would work and other timesnot so much, but now it seems to be leaving these small bumps all over my face. They are not pimples, also my face is still red after using the product now. I have medium rosacea, but I get flare ups that can get bad. I’m 19 year old female.

  28. Teri says:

    I have been using Rhofade for about 8 months, and I can really see a difference in my rosacea. I’m Norwegian and Swedish, very fair, and this has been better than Mirvaso, Finacea for me. I really like it.

  29. Susan says:

    Started soolantra nightly and rhofade daily a wk ago. I think the rhofade and I are not getting along. My face has been itchy like crazy, raised bumps like ant bites and red. My skin was clear with pink cheeks. I plan on following up with my dermatologist to see if this is a reaction or demodex die off.

  30. Angie says:

    I’m in my late 30s and I developed rosacea during my mid twenties during a pregnancy. A few years ago I was prescribed Mirvaso and it was a miracle for me…for a while. It was the first time I my face was not red for years and I could go with no makeup. However, I noticed the rebound redness but it was always at the end of the day so I didn’t worry about it. Usually by morning it was less red and I would reapply anyway so it wasn’t inconvenient for me. Then I ran out and went several months without it. When I started using it again the rebound redness was terrible. It started happening in the afternoon and my face felt like it was on fire. I started applying it twice a day and then by bedtime or in the middle of the night my skin would burn. My dermatologist suggested Rhofade a few months ago so I switched over. Here is my assessment of Rhofade vs. Mirvaso for me:

    Mirvaso is more affective in the short term, meaning That it creates a huge rebound redness but before that sets in it really did get rid of all of the redness for several hours for me and it was like I didn’t have rosacea at all. Rhofade On the other hand does not cause any rebound redness for me but it also does not get rid of all the redness either. It comes in a thicker white cream that takes a lot of rubbing of the skin to apply it and that application is what flares up my face the most, and unfortunately the medication does not work well enough to calm my skin down. Mirvaso came in a light refreshing gel that I didn’t really have to run in. I could lightly pat it in instead. But Rhofade is like thick white sunscreen that just sits on top of the skin of you don’t rub it in. Rhofade doesn’t seem to do anything to help my rosacea other than help ween me off of Mirvaso. Right now I am just focusing on decreasing stress and eating non-inflammatory foods. I also went to Sephora and purchased a neutralizing product called cicapair and it has been really soothing to my skin for wearing under makeup.

    Good luck fellow rosacea sufferers! I wish there was a magical cure to this terrible condition but I really think managing it day to day is probably the best we can hope for

  31. sr840910 says:

    Be EXTREMELY careful with this medicine. I had minor redness of the face after taking accutane for 6 months. My doctor gave me Rhofade all nonshalantly. I began to use it once a day everyday for a few months. Well slowly I realized it was actually making my face more red. When I would not put it on, my face would be bright red, making me look ten times worse. I have completely stopped taking it now for about a month and my face is still very red. My doctor prescribed me doxycycline to help get rid of the redness but it is not working good. Does anyone have any suggestions? I would rather take a pill instead of a topical at this point. I tried propranolol but it made me dizzy and light headed. Please, anything would help I am desperate!

  32. Theresa says:

    Just like may of you, I also received some free samples of Rhofade from my dermatologist (This happened last week, so I’ve only been using it for a week, but had some interesting things happen, so I’ll update more later.). A few years ago, I started using a cream from Costco called Infinite Aloe Skin care. This seemed to really help with my rosacea and control it from moderate-mild to just mild. (I have rosacea only on my cheeks and temples, but a little bit on my chin. I use this lotion 2-3 times a day (I love it because it works/keeps my skin feeling moisturized/not dry, doesn’t sting or turn my face redder, and doesn’t leave a lotion-y/slippery feeling/it absorbs right into the skin).

    On to what happened with Rhofade: Like many of you I saw little to no improvement in the first few days with Rhofade. I’m not using anything on my face other than the lotion mentioned above, so there should not be any drug interactions.

    The next few days with Rhofade, I tried to not notice. I wish I took a before-Rhofade-pic, but I didn’t. I’m logging everything right now in pix. So I noticed that Rhofade would make my skin a little itchy and dry (however, if I didn’t use the Infinite Aloe lotion mentioned above, my skin was dry and itchy anyways before Rhofade.)

    Today, I noticed my face is a lot redder than before Rhofade. I started reading reviews because this was the first day I noticed 2 white heads that were deep in my skin, and I’ve never had acne like that before! I am noticing a lot of pimple-like bumps, but when I glide my finger over them, my skin is smooth. I think they might have always been there and the Rhofade just took the redness away from my normal, surrounding skin, but made those pimple-looking bumps or scars redder.

    I then put honey on my face for 30 minutes. After washing the honey off, my face was almost the same color it was before Rhofade! I did still notice the pimple-looking bumps, but also that I think more of the non-bumped skin was much more pale!

    I tried an oatmeal mask next for 10 minutes to see if I could see more results. This mask was less effective, but it did make my face look a little more pale.

    Needless to say, this encouraged me to keep trying Rhofade in hopes that it just needs some time to work. Also, maybe I need to wash it off my face after an hour or so of applying Rhofade? It might be clogging pores after the medication is absorbed in, or the alcohol in the Rhofade (if any) might just be making my face red temporarily.

    I haven’t seen much follow up on here or many reviews after 1-2 weeks use of Rhofade, so hopefully that changes in the comments and people will tell their stories so others know if they should keep trying or not. I will try to come back and comment my results after a month of Rhofade use.

    • Katherine says:

      For some of us it’s not a matter of time for it to work. I had a pretty severe allergic reaction to it. That was only after using it 3 days and that took over 2 weeks for it to go away. I’ve discovered that with my rosacea I can’t use anything with alcohol in it and Rhofade has 4. I mentioned this to my dermatologist that I was sensitive to alcohols and she prescribed it anyway. Likely didn’t think another it. Rhofade for me did initially work though and the results were drastic. But sadly it let to a pretty severe reaction.

      • Theresa says:

        That sucks! I didn’t mean to tell people to wait it out if they are allergic, just that I’m going to try and log this out for those wondering if it gets better if they have an experience similar to mine or if they want to know how long it took for the redness to go back to how it was before Rhofade.

        I didn’t see very much information about what happened after people stopped using Rhofade and if their skin got less red after quitting… I was very concerned when I started to notice my face seemed worse at a quick glance, and I couldn’t find anyone talking about what happened months after quitting Rhofade / if their skin went back to how it was before Rhofade and how long it took.

        I have a mirror that magnifies on one side and has very good lighting on both sides, so I wanted to point out that even though in the bathroom mirror my face seemed more red than before Rhofade or was more red overall, that when I took a closer look, I noticed the pimples were what was worse, not the skin surrounding them, which is important because pimples can come and go, so I figure if this makes the skin more pale, then once the pimples go away, everything will be paler.

        • Juanita says:

          My face returned to normal after 30 days. Actually, the redness toned down (yay!), but now it’s summer, and I live in extremely hot summer territory, so….yeah. By the comments, we can see there’s a small minority in which Rhofade DOES work, but for the rest of us, it’s irritating in more ways than one. Anyone else have your face return to normal (pre-Rhofade use)?

    • Theresa says:

      Update: On 6/1 (almost a week ago) I went to my dermatologist because I wasn’t sure if my skin was getting better and to keep trying Rhofade and honey masks or if I should stop because my face was getting permanent damage. I told him about how after week 1 (my OP is from week 2), I was using Rhofade for about an hour then rinsing it and wearing a honey mask for another 30 min to an hour and seeing that my face was getting more pale for a few hours. He said that leaving Rhofade on for a few hours isn’t long enough to make it work (I’m sure it was doing it’s thing even though I was getting less pimples) and told me to stop using it because it gave me a lot of papules wherever I applied Rhofade on my face.

      I realize now after a week off of Rhofade that my face doesn’t get as pale with the honey mask, so Rhofade must have been making my face more pale AFTER the honey mask, but that my face is VERY slowly getting back to how it was before Rhofade. My dermotologist said it could take up to 6 weeks for the pimples caused by Rhofade to go away, but I’m seeing them dissipate much quicker, probably because of the honey. Right now, my face is almost back to how it was, I just have the (now much smaller and less red/pink) pimples.

      In addition, I realized that Rhofade WAS actually making my face redder during the day (I put Rhofade on after work each day, so during work my face was super red [rebound redness], but while I was at home after applying it, my face was much more pale than ever before after a week of using it because in the first week with Rhofade, my face only got redder). I also noticed that Rhofade made my skin more sensitive to other things (the lotion I mentioned in my comment above started hurting and stinging my face).

      However, I do believe that Rhofade WAS making my face much paler and paler each day right after applying it for a few hours only though. I don’t think it’s worth it if it gives you the papules though. If this cream only makes your face red, then I would keep trying it for a few weeks to a month and then see if it starts making your face look pale. My dermatologist said it won’t permanently make your face paler though, you’d have to keep applying it, so I don’t see the point in trying it if you have mild rosacea like I did.

      I would say go for it if you have severe to moderate rosacea where you can’t cover up the redness with makeup or you already have rosacea acne. I would advise against Rhofade if your rosacea is mild/ only pink like mine was. This wasn’t worth it, but I’m glad I only used free samples and that my face is progressively getting better each day (even when I Was on Rhofade after the first week).

      I’m sorry I’m not trying it longer than this time period (3 weeks), but I hope this helped and I will try to come back and update when my face is back to how it was before Rhofade.

      • Theresa says:

        * correction: I was on Rhofade for 2 and a half weeks not 3. I started on May 15th and stopped on June 1st

  33. Megan says:

    I love rhofade. I used mirvaso for years and dealt with the rebound redness every day. I forget I have roscea using this cream. Sorry to hear about all the people it does not work for.

  34. Janet says:

    My dermatologist recommended Rhofade for mild rosacea – would only break out once in awhile. After using it for two nights I am stopping. My face looks worse than it did before I started using it. I was using Calm by Aveda before and will go back to that. An expensive lesson!!

  35. John H says:

    I’ve been using Rhofade for about a year now, and I still love it. In addition to rosacea, I have psoriasis and seborrheic dermatitis. I can’t use it when my SD is acting up or when I have a rosacea flare when I get lesions (my flares are really bad) because it stings and seems to inflame it. Luckily, my deem seems to have found the right combo to get things under control. I use Soolantra, sulfacetamide sodium lotion, and doxycycline. My wife is making me be gluten free too, so who knows what exactly it is, but the rhofade is the thing that makes the red go away for most of the day.

  36. Thomas says:

    My impressions about Rhofade:

    I have a mild persistent erythema and some flushing since 3 year. I had a very bad experience with Mirvaso. To me, Rhofade is – with IPL, beta blockers and sunscreen – one of the rare medical option who really work on my flushing. (Honey cream, Azelaic acid, green tea cream, botox, Mirvaso (it make worse !) : all this drug doesn’t work on my flushing)

    Rhofade on my skin:

    – Full effect after 3 hours
    – Full effect during 7 hours + after half effect during 2 – 4 hours
    – After 5 months : absolute zero side effect
    – Visually: my skin is 100% white. Only in huge stress situations or very warm rooms my skin is 80% white (20% red)
    – Disadvandtage : doesn’t prevent the momentary redness (15 seconds), it doesn’t remove the burning sensation that characterizes rosacea (even if you are not red), the price (very expensive)

  37. Rebecca says:

    My derm is strongly encouraging me to try Rhofade. I have persistent all over redness with no bumps or lesions. My skin texture is a bit rough with enlarged pores.

    I tried Mirvaso about 15 months ago. I stopped after 4 days due to a horrible rebound effect. Intense localized redness, burning, plus puffy, swollen areas. I will say that after my skin returned to normal – which took about two weeks (two weeks where I was terrified that it would never become normal) – my skin was actually BETTER than normal. This improved condition, which included reduced redness and generally improved texture, lasted about six months. For several months now I’m basically back to normal-normal. Which sucks.

    So derm asked the drug reps about my reaction. And they told her that it’s important to push through the rebound period and continue using. That you will then break through the rebound and it will cease. Only good effects.

    I am very torn. The first two days with Mirvaso before the rebound were like a dream. No red at all.

    Has anyone here gone through the rebound period and had the negative reaction stop?

  38. Philip M says:

    I was given a Rhofade sample 3 months ago by my dermatologist, I tried Mirvaso in the past and found it had minimal effect, other than a short term whitening/bleaching, so stopped using it. The only topical skin scare medication I use regularly is Soolantra, which eliminated the postures I was getting. and I accepted the redness that came with rosacea. Immediately Rhofade eliminated the redness, then I read this forum and found all the negative reactions other rosacea sufferers had with it and was dreading the same reaction other users had found. Fortunately this didn’t happen and, 3 months later, the combination of Soolantra and Rhofade is giving me the best outcome I’ve had in years. We’re all different and Rhofade isn’t a ‘magic bullet’ for everyone, I just got lucky and it works great for me. No one knows what their outcome is going to be, unfortunately the only way to find out is to try it and accept that it could be a great solution or you may have the counter indications others report. I was prepared to continue with it despite reading all the negative responses.

    • MIke F says:

      Paul, I remember your post 2 years ago. Everyone politely asked you to fill us in on the “miracle cure” you had but you refused to post it, instead telling people to privately email you. Again you post about your amazing cure but again you fail to tell anyone here how you “cured” your redness.

  39. Paul Mullally says:

    It saddens me to see so many people suffering with this terrible condition. But we need to be realistic about the big pharmaceutical companies. What successful pharmaceutical company is going to find a cure for Rosacea when the real money is in designing and manufacturing products which only treat the condition. I think we all know that a cure does exist. I am walking proof of that. I suffered from Rosacea in my late 50’s but now I am 63 and have been clear of Rosacea for 3 years. I went through the various wonder drugs which promised to alleviate my symptoms but which in fact only made the problem worse. Look around you as there is a cure. I posted here 2 years ago that I was cured but I was abused and vilified by many of you sufferers. If you people are still here , the last laugh is on me. I am cured. It amazed me that so many people are so easily brainwashed by the big pharmas.

    • Ron says:

      What was the cure that worked for you Paul? As someone who has suffered with Rosacea for a number of years & am somewhat thinking of trying Rhofade even with all the negative reviews on this page, I would rather go with a permanent solution. Like everyone else I’ve tried
      a lot of other treatments but none have really worked all that well for me. Any information you have on your success would be greatly appreciated.

    • MIke F says:

      Paul, I remember your post 2 years ago. Everyone politely asked you to fill us in on the “miracle cure” you had but you refused to post it, instead telling people to privately email you. Again you post about your amazing cure but again you fail to tell anyone here how you “cured” your redness.

      • Paul says:

        Incorrect. I did post my cure here and on many other rosacea helplines. As I received such abuse and I was in fact banned and blocked from many sites I deleted my posts. Recently I saw a message but I am not going to post anything public. I will take the cure to my grave rather than think some of the people who abused me got any relief from their symptoms. Cheers. Paul

  40. Wes Perry says:

    I got a prescription for Rhofade and the first time or two it seemed to work vey good. After about two days I lite up like a fire cracker. Stopped it and the extreme redness went away. Presently use Metronidazole .75% and it helps. Any suggestions Wes

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