Rhofade User Reviews


Allergan’s Oxymetazoline based cream, Rhofade (oxymetazoline hydrochloride cream 1%) – for the treatment of the redness of rosacea is now generally available. Does it work to effectively and safely reduce the redness of rosacea? You have come to the right page to find out.

Some Oxymetazoline History

For rosacea sufferers it has been a long development cycle, the story starting with the emergence of Oxymetazoline as a rosacea active in 2007. Aspect Pharmaceuticals, Vicept Therapeutics and finally Allergan were owners of the intellectual property behind Rhofade, which first came to our attention through a 2005 patent (20050165079) by Shanler and Ondo.

So it has been a very long time since rosacea sufferers first starting hearing about the active in products like Afrin being a possible treatment for the redness of rosacea.

What is Rhofade?

Rhofade is being promoted as ;

The first and only α 1A adrenoceptor agonist approved for persistent facial erythema associated with rosacea in adults.

This is sales-speak as Mirvaso has been available for several years now and is similarly promoted as the only `α adrenoceptor agonist’.

Is Rhofade the same as Mirvaso?

If you were to solely read internet reviews of Mirvaso you could be forgiven for thinking that Mirvaso has been a very problematic product for Galderma (see Mirvaso Reviews). The adverse reaction rate to Mirvaso during the clinical trials before approval does not appear to be borne out by subsequent internet respondents. It isn’t clear why this appears to be the case – more frequent adverse reactions experienced outside the tightly controlled and monitored environment of the blinded clinical trials.

Every rosacea sufferer looking for relief from their red face is hoping that as claimed, Rhofade really will prove to be a “topical treatment of persistent facial erythema associated with rosacea in adults.”

Rhofade – the successor to Mirvaso?

It isn’t yet clear what Allergan have been able to do with the commonly available active ingredient Oxymetazoline to package it as palatable to the sensitive skin of rosacea sufferers. One clue appears to be the usage of “more selective for α1D-adrenoceptors are less prone to induce receptor desensitization than are α1A– or α1B-agonists” as found in the off the shelf products”. Although we know now that Rhofade is being promoted as a α 1A adrenoceptor agonist.

Certainly we are all hoping that Rhofade will become a well liked and tolerated rosacea treatment, that is true to the 1 year, only 3% adverse reaction rate generally experienced during the Rhofade clinical trials.

How much improvement will I see?

It is worth tempering your hopes for success with Rhofade with the published clinical trial data that shows that ;

Will RHOFADE work for me ?

Going on the published clinical data, basically one in 6 or 7 users of RHOFADE will have a 2-grade improvement in their facial redness, typically for 12 hours, and continuing for 29 once-daily uses.

Rhofade Reviews

So finally, rosacea sufferers are able to fill a prescription for Rhofade. Please let your fellow rosacea sufferes know what you think of Rhofade, we are especially interested in any rebound redness that your might experiences.

Please leave a comment below. Thanks!

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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11 Reader Comments

  1. Rudolph Rob says:

    I am getting some samples today from my derm, I’ll post in a week or so to let all know. My nose redness comes and goes so not sure how I will know if it’s working but I’ll take one for the team and try it.

    • Rudolph Rob says:

      Played golf today, it was on the cold side, breezy and damp. Needless to say by the end of the round or somewhere in between I was in full blown rudolphitits (bright red nose). I had to leave the restaurant where everyone was gathering after the round because I was too self conscious about it. I had thought it was getting better through all the treatments I was applying over the last year but I was wrong, it was as if I had been doing nothing with how red my nose looked. Last week I received some Rhofade samples to try but I was reluctant because of possible side effects and the fact that I thought things were under control and did not want to cause a major breakout but after today I have had it with this #%*%$@@!. I used just enough for a very light coating on the lower portion of my nose, my nose redness did calm down shortly there after but it could have been from being inside for awhile. It will take a few days to know if it causes breakouts as right now I am clear of P&P’s. I’ll post in about a week or so and let all know how it went.

      • Patryk Lamch says:

        Rob, it’s better or no? I did’t understand, my english is not so good. Please write more details.

      • Rudolph Rob says:

        I was outside today for a few hours, it was a nice sunny day about 65 degrees. This morning I washed my face as usual with Cetaphil gentle skin cleanser (not facial wash) and applied very thin coat of Rhofade on my nose and a little on my cheek area (not whole cheek) and then I applied the Cetaphil Daily facial moisturizer with SPF 20 (Redness relieving tube) very thin coat as well. I did not moisturize today for some reason, just forgot. I was happily surprised that all day long there was no redness but between the Rhofade and Cetaphil redness relief stuff the area I coated was a little greasy but I’ll take it any day compared to what it was yesterday.
        I am only using a very fine coating so be careful if your just starting with Rhofade, ask your doctor if you have any vascular issues because I had a few funny feelings after applying Rhofade (could be my imagination) also I have not developed any pimples as of yet. I am satisfied to this point but it’s only been 2 days but as any rosacean knows 2 days using something new can reek havoc on your skin.
        I’ll post again next week.

  2. David Pascoe says:

    Comment via email.

    “David I can’t afford rhofade tried soolantra an mirvaso they didn’t seem to work what would you recommend rhofade is 500. A tube”

    Hi Richard,

    were you told my a pharmacy that a tube is $500 ? Is the price without insurance?

    “Cheap” and “rosacea” don’t typically go together, sadly.

    You could try

    For some suggestions.

  3. SA119 says:

    Really looking forward to some real life experiences. If we have learn anything its that you just cant count on Trial Results-They mean nothing!

  4. Daphne May says:

    My dermo gave me samples, thank goodness since is stratospherically expensive. It caused pustule acne and the redness did not improve after 2 weeks of use.

  5. Dana says:

    I have tried everything but the treatment the only thing that remotely helps is being on antibiotics but you can’t do that all the time. The other thing that works is Merle Norman anti redness line of creams and cleanser. They worked better than the creams my dermatologist recommended and cheaper too.

  6. Brian says:

    Has anyone had results with Rhofade for severe atopic dermatitis with significant erythema (redness) ?

  7. Alex says:

    Hello! does anybody have any idea when Rhofade might be available in the UK? Thank you!

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