A recent article published in Clinical, Cosmetic and Investigational Dermatology hints at 3 new active molecules that show promise for the redness of rosacea.
The combination of caffeic acid, rosmarinic acid, and gallic acid (RGC for short) is described as a new potent dermocosmetic ingredient. The research concludes `that 2% RGC topically applied on the face for 28 days improved erythematotelangiectatic rosacea symptoms either by decreasing them (in half of the volunteers, vessels are less visible) or by limiting their development (any neovessels seen)’.
The paper tells us that ;
The choice of molecules to form the active ingredient was based on the literature analysis, showing that caffeic acid, rosmarinic acid, and gallic acid get interesting biological properties that could be useful to slow down the pathological process of rosacea.
The active molecules mentioned appears to be covered by this patent as they all rate a mention, along with other actives.
Composition and method for treating rosacea, WO 2009042402 A2
A composition for the treatment of skin exhibiting the symptoms of rosacea, and a method of treating the skin of an individual suffering from rosacea, are disclosed. The composition comprises a hydroxycinnamic acid and/or a methoxycinnamic acid and a suitable carrier for topical application of the composition to mammalian skin. The composition and method reduces skin redness, flushing, pimples, pustules, and skin bumps associated with rosacea.
The claims in a patent application are just that, claims. Almost any claim can be found in a patent application, but it can still be instructive to see where the claimant thinks their invention has intellectual property. This patent application and others make some interesting claims.
Rosmarinic acid is found in large quantities in oregano, lemon balm, sage, marjoram, and rosemary. Rosmarinic acid has antioxidant, anti-inflammatory and antimicrobial activities. The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis. Perilla, rich in rosmarinic acid, is used for its anti- allergic activity. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation.
Caffeic acid is found at high level in some herbs, especially thyme, sage and spearmint.
1 October 2015 Volume 2015:8 Pages 501—510.Chajra H, Nadim M, Auriol D, Schweikert K, Lefevre F
Background: Rosacea, a common chronic skin disorder, is currently managed by patient education, pharmacological drugs, medical devices (laser and light therapies), and use of proper skin cares. Unfortunately, none of these actual treatments used alone or in combination is curative, and so we proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for erythematotelangiectatic rosacea.
Methods: Dermocosmetic active ingredient is composed of three glucosylated derivatives of natural plants hydroxybenzoic acid and hydroxycinnamic acids (rosmarinic acid, gallic acid, and caffeic acid). Anti-inflammatory, anti-angiogenesis, and anti-degranulation studies were done on cellular models (keratinocytes, mast cells, and endothelial cells). Efficiency of the active ingredient in comparison to placebo was assessed clinically on human volunteers having erythematotelangiectatic rosacea. The active and placebo were applied topically twice a day for 28 days. Biometrical analyses were done using a siascope tool.
Results: We found that the active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and controls angiogenesis mechanism (inhibition of the production of vascular endothelial growth factor and neovessel formation) on cellular models. Study on human volunteers confirmed macroscopically the efficiency of this active ingredient, as we observed no neovessel formation and less visible vessels.
Conclusion: Although rosacea is a skin condition disorder that is difficult to heal, the studies have shown that this active ingredient could be a dermocosmetic support, especially for erythematotelangiectatic rosacea armamentarium. The active ingredient was topically applied on the face for 28 days and improved erythematotelangiectatic rosacea symptoms either by decreasing them (vessels are less visible) or by limiting their development (any neovessels). The active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and limits the angiogenesis process (inhibition of vascular endothelial growth factor production and neovessel formation).
Keywords: rosacea, erythema, gallic acid, rosmarinic acid, caffeic acid, glucosylation
This research has surfaced an interesting result that if replicated in future studies could point to a possible future treatment for the redness of rosacea.