resorcinol and sulfur: small reductions in redness and visible vessels

Written by on March 4, 2006 in To Be Filed with 0 Comments

Resorcinol (re-SOR-si-nole) is used to treat acne, seborrheic dermatitis, eczema, psoriasis, and other skin disorders. It is also used to treat corns, calluses, and warts. Resorcinol works by helping to remove hard, scaly, or roughened skin

I found one preparation, Acnomel Acne Cream that contains Resorcinol 2%, Sulfur 8%, alcohol 15%, bentonite, carbopol, fragrance, iron oxides, octoxynol-9, potassium hydroxide, propylene glycol, titanium dioxide, water.

Evaluation of a topical treatment containing 8% sulfur and 2% resorcinol in the treatment of centrofacial rosacea

Marianne Stoudemayer, RN, Yaxian Zhen, MD, PhD, Tracy Stoudemayer, Albert Kligman, MD, PhD, S.K.I.N. INC, Conshohocken, PA, United States

A combination topical treatment containing 8% sulfur and 2% resorcinol has been shown to be an effective treatment for acne vulgaris. To evaluate whether this combination drug is also helpful in rosacea, we recruited 15 female volunteers, aged 43 to 52 years, with classic centrofacial, erythematotelangiectatic rosacea. Ten subjects received the active treatment bid for 3 months and 5 subjects received vehicle for the same period. A number of bioengineering methods were used to assess facial skin at baseline and at 2, 4, 8, and 12 weeks. In the active group digital photography and videomicroscopy showed moderate reduction in the appearance of telangiectatic vasculature. Colorimetric measurement showed a small reduction in redness; blood flux imaging by a laser Doppler device showed decrease in blood flux. Compared with this, the control group (vehicle-treated) either showed no difference or worsening of rosacea posttreatment. The global assessment by the subjects also indicates the improvement of rosacea in the active group.
Author disclosure: Nothing disclosed at press time. Supported by Numark Labs Inc, Edison, NJ.

Poster Discussion Session P114, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.

Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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