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Always quick to generate a press release, Pyratine XR has been seen some recently published research, this time on the long term efficacy when treating mild to moderate rosacea.
This latest research is in addition to the May 2009 JDD article, Topical PRK 124 (0.125%) lotion for improving the signs and symptoms of rosacea, and the 2007 Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea
So now we have the June 2010 Journal of Drugs in Dermatology article; Long-term Efficacy and Safety of Topical PRK-124 (0.125%) Lotion (PyratineXR™) in the Treatment of Mild-to-Moderate Rosacea.
Although this study only included 14 patients, it did last 48 weeks which seems to be much longer than the usual period for a study of this type. It is potentially good news that Pyratine XR offers sustained benefit over the long term.
At worst the product didn’t seem to induce an irritation and at best offers a measurable benefit for the redness and papules and pustules of rosacea.
Pyratine XR continues to attract only modest attention in the online rosacea forums. For some snippets of user feedback see Pyratine XR user reviews.
J Drugs Dermatol. 2010 June;9(6):647.
Background: Many patients with rosacea cannot tolerate extended treatment periods with topical agents because their skin sensitivity is often increased.
Objective: To determine the long-term efficacy and tolerability of a new moisturizing lotion for improving the signs and symptoms of mild-to-moderate rosacea.
Methods: In a 48-week, open-label study, a moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK-124 (0.125%, Pyratine-XR™, Senetek PLC, Napa, CA) was applied twice daily by 18 subjects with mild-to-moderate rosacea. Clinical improvements were assessed by the treating physician. Skin barrier function was measured by transepidermal water loss after treatment. Tolerability and cosmetic outcome were evaluated by subjects.
Results: Subjects experienced a mean 44 percent reduction in erythema severity and a mean 89 percent reduction in inflammatory lesion count at week 48. Reductions were significant (P≤0.05) in both erythema and lesions at weeks 24, 36 and 48. Statistically significant (P≤0.05) improvements in telangiectasias, transepidermal water loss and dryness were noted. Overall clinical improvement was observed in 81 percent of subjects and the investigator’s global assessment steadily improved throughout the study. Treatments were well-tolerated and cosmetically acceptable. Treatment-induced skin irritation was not observed.
Conclusion: The new moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK 124 is efficacious, does not irritate skin, and is well tolerated for at least 48 weeks.
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