Pyratine XR User Reviews


Showing just how important the internet is becoming for marketing new cosmetics, Pyratine XR has recently launched with a lot of press activity. As well as Senetek’s press releases on the internet I was also contacted by 2 PR representatives trying to get me to cover the release of this `new’ product. Pyratine XR was launched at the South Beach Dermatology Symposium in Miami on Feb 14 and also on March 6 at the AAD Annual Meeting in San Francisco.

The press release activity is based on an as-yet unpublished study of 18 mild to moderate rosacea over a period of 48 weeks.

So what is the difference between Kinerase, Pyratine-6 and Pyratine XR ? Well firstly they are all expensive over the counter cosmetics. The active ingredient in these products is furfuryl tetrahydropyranyladenine. As cosmetic products none of these can make claims to treat any particular disease.


Kinerase Cream contains 0.1% N6-furfuryladenine.

The ingredients of Kinerase are listed as: purified water, glyceryl stearate and laureth-23, isopropyl palmitate, propylene glycol, stearic acid, cetyl alcohol, carthamus tinctorius (safflower) seed oil, soya sterol, stearyl alcohol, dimethicone, imidazolidinyl urea, citric acid, sodium hydroxide, methylparaben, soluble collagen, carbomer, N6-furfuryladenine, panthenol, propylparaben, triethanolamine, ascorbic acid, hydrolyzed elastin, and aloe barbadensis leaf juice.


Pyratine 6 contains 0.1% N6-furfuryladenine and is marketed as an anti-aging product and as Senetek’s `second-generation patented cytokinin’

Pyratine XR

Pyratine XR contains 0.125% N6-furfuryladenine and is marketed as a rosacea product once Senetek increased the amount of the active ingredient and initiated the unpublished study mentioned in this article. It looks to me that the Red R in the labelling is also trying to suggest that this product is for rosacea sufferers.

Product Feedback

There is some strong skepticism about Pyratine XR over at the Rosacea Forum

I agree with Melissa:

  1. The stuff is ridiculously expensive
  2. It went “cosmetic” as to avoid having to conduct rigorous testing
  3. It’s claims are yet to be approved by the FDA as far as I could find
  4. There are no 3rd party tests of this product, only in house research done by the company
  5. In the tests that were done the claim was that it was tested on people with mild to moderate rosacea, but the test data itself remains largely unpublished.
    Are you kidding me? If the two test subjects pictured are the best examples to sell this product then it appears to only work well for those with really, really, really mild Rosacea.
  6. I haven’t heard one good thing about Pyratine 6 from a real Rosacea sufferer, it is hard to imagine why this is going to be that much better
  7. Spamming Rosacea web boards for business suggests a $ grab
  8. I don’t know why this plant derivative substance is significantly different from others that have been around for some time that claim to also be anti-inflammatory and effective on ROS.
    Bottom line, there is no real reason to believe this product will work imo, but the jury is out. Once is comes out, if some reliable people post good results it might be worth a try. I would prefer seeing a large scale 3rd party double blind study on it.

Pyratine XR was due to be launched at the SF AAD Meeting. An interesting post from badhairday gives some insight into what this launch actually meant ;

Hi all,

Thought this would be helpful info re: Pyratine XR. I realize I don’t regularly post but I thought this was important. My sister in-law is a Derm. She attended the National Dermatology Conference in San Francisco this past weekend. I asked her to find this product and try to get me the inside scoop – like all of us I am cautiously hopeful of anything new but also skeptical. Here’s what she found.

The Pyratine XR booth – was a VERY hard to find tiny booth. There were two women representing the product (she said the ladies seemed a little sketchy – not necessarily important info but I trust my sisters judgement ). Just a few before and after pictures of people who had trialed it for 48 weeks – but NO real data on how the product works and the women wouldn’t get into any detail. They would only conditionally commit to give her 6 free samples (enough for the 48 months per patient) BUT the Dr. had to commit to recording results of their patients (data and pictures) through the period of the trial and report back to the company. If the Dr. didn’t want to commit to the following though on data gathering they would need to pay $400 + per patient (for an 48 month trial). This product will be sold over the counter only in physician offices (no pharmacies). My sister-in-law was concerned that this company was trying to solicit Doctors to do the research for them for free rather than setting up an actual study where patients are paid. Further she was sceptical that they wouldn’t give any free samples (it is $150 per tube!)

She reported that b/c it’s over the counter it doesn’t have to go though any “real” testing (a lot easier to get approved). Just need to prove that it doesn’t harm anyone. It seems to be a glorified anti aging product with natural plant exact ingredients which probably will be ok for many of us to use as most of the ingredients looked fairly benign. But it’s hard to say if it will have any effect on rosacea at this point. Her recommendation was to wait a year and not spend the money as it didn’t look promising enough and it didn’t have enough to back it up that would make it a worth while product at this point. Sorry to burst any bubbles – and again what doesn’t work for one may work for another and obviously a few people on this sight have had some luck. The product representation just seemed a little sketchy for me.

Good luck all – hope this helps a few of us to save a few bucks and… Jen

Paula Begoun has this to say about Kinetin.

Kinetin is a plant-growth hormone, and its technical name is N6-furfuryladenine. What makes kinetin interesting are the in vitro and animal studies demonstrating its effect as a growth factor.

I suspect that when it’s applied topically, kinetin isn’t of much use to the skin cell, and even if it could be utilized, there probably isn’t enough kinetin in any product to have a negative or positive impact but that is only a guess, no one knows for sure (Source: Dermatologic Clinics, October 2000, pages 609-615).

User Reviews & Feedback

As Pyratine XR has only recently launched there aren’t many testimonials available yet. Here are some thoughts from users of the related product Pyratine 6.

From DukeCity; I still am using the creme and think it’s the best moisturizer I’ve ever had, as far as toning down redness it’s so subjective, as I’ve had multiple IPL/Laser TX and am taking Oracea daily. But it is the only topical I’ve been using since last Feb./March. I will definitly be buying the Pyratine/RX as soon as it comes to public sale…

From dallascowgirl; On March 14, 2009, I will have completed a year using Pyratine- 6 lotion. (I tried the cream but it made my skin break out.) I still like it as much as ever– the first moisterizer I’ve ever been able to use. In this year, I have only used two 2.5 oz. tubes. I use a pea size glop twice a day while my face is slightly damp. I have had acne rosacea since I was 13 years old. Today, I have no breakout and my face skin is smooth, a little pink on my chin. Though it is expensive, I think I’ve actually saved money this year from not running out and buying the newest cream every month. Will I try the the new one? I really haven’t decided yet.

From sophie; I started using Pyratine last sept or oct, and loved my skin more after only a week or two. There has been a SMALL reduction in P&Ps [I still have them]. Likewise a SMALL reduction in redness [I’m still red]. The BIG difference was in the overall smoothness of my skin. Its still rougher than your average persons, but I’m quite sure that its the smoothest its been since pre-puberty [I’m now 33]. Funnily enough, I wonder whether my spider veins are now more defined now cause my skin is clearer. The other downside is that prolonged use hasn’t made my skin any better i.e. the almost immediate improvement has remained but not increased.

Over to You

So now that you have read all this background information, do you plan on trying Pyratine XR ?

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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14 Reader Comments

  1. Apparently the trial is due to be published in the Journal of Drugs in Dermatology May issue pp 459-462. I can’t see it online yet, but will keep an eye out to see if it becomes easily available for us to read.

  2. Further, you can see the 2008 paper on the 0.10% formulation at PubMed A clinical study of topical Pyratine 6 for improving the appearance of photodamaged skin.

    Also see the Clinical Trials register for the 0.125% formulation known as `PRK 124′ clinical trial Effects of PRK 124 Lotion in Acne Rosacea. “The purpose of this open-label study is to determine the tolerance and efficacy of twice-daily application of PRK 124 (Pyratine-6)(0.125%) moisturizing lotion for improving the signs and symptoms of mild to moderate facial rosacea.”

  3. GJ says:

    If I was a naughty seller of a topical I would be tempted to suggest that the testee wear lipstick for all ‘after’ shots, to better hide the naughtiness.

  4. antoinette says:

    I am wrting concerning the effects of Pyratine-6. Last October 2008 I ordered lightening gel and small dose of liquid for a TCA Peel by internet from a reputable company in Detroit. The first 3 weeks my Italian under eye dark circles…gone and then the peel to slough off remaining skin. B Feb. 1st..returned and I was left with dark scars…no hyrdoquinone..s I was surprised and sick that had ruined my skin. I immediately went to a reputable skin specialist in Illinois and she put me on Pyratine-6 and I do not have rosacea. My skin has healed from the burns and now we are working on lightening my skin from the black char scars. I hope that I can help women and men from buying anyting off the internet unless you have a doctors recommendations. The company in Michigan has it’s own estheticians and they are NOT DOCTORS. Your facial skin is what we wear and cannot take off like clothing. I would rather have had a bad this has truly thinned out my skin and wrinkled the once tone in my lower eye area. Thank goodness I went to the skin doctor n Lincolnshire Illinois and she put immediately on the road to recovery to skin regeneration and smoothness. We are working on the dark black splotches and pit mark it left (peel and lightener). I wanted Renova..but I was told it would burn more. I am so pleased with my results with no burning and actually my skin after 7 weeks is smooth again. I will never let anyone on the phone tell me how to do any facial treatments as they know best and that doctors are higher price. YOUR FACE AND SKIN…deserve the best. Pyratine-6…you have a real winner and after seeing the softness and smoothness at 56…all ages could benefit from this and never go back to harsh treatments as Retina/Renova/even peels. Darker and olive skin like mne scar and take years to go away or never. Thanks again

  5. queta says:

    I have rosacea quite bad and am using Pyratine XR. It is helping my skin texture and overall blotchiness. I really, really like this product. I know a lot of people are skeptical but for me (mostly phymatous rosacea) it is really helpful. It is expensive but I will continue to use it. I am very happy I found it.

  6. Erick says:

    I’m just a regular dude, sports freak surfer in my 40’s who was given some Pyratine XR samples at my dermatologists office.

    I do not have rosacea or any real skin problems, other than normal age and maybe sun.

    I have been using this stuff on my whole face and neck for a few weeks after shaving, and it seems like my skin is way better, which was totally a surprise.

    Maybe it’s just my imagination, but my skin seems to be way smoother, really clear and looks tauter and the lines around my eyes, etc, diminished by about 50%.

    Like I said maybe it’s just my imagination, but it sure seems to make my skin look good.

  7. PubMed is now showing the paper mentioned above.

    Topical PRK 124 (0.125%) lotion for improving the signs and symptoms of rosacea.

    The conclusion of the paper ; “The new moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK124 shows a continued trend toward improvement of skin barrier function and the appearances of erythema and papules associated with mild-to-moderate rosacea during 12 weeks of treatment.”

  8. Daria says:

    This stuff does not work. There is a reason there is not a prescription for it. Who has $150 to waste on a product, an itty bitty tube, that makes you REDDER after you wash your face and then the lotion does NOTHING to calm it? None of the doctors I’ve been to even know what Pyratine is. Invest your money in something that’s actually been clinically tested and is FDA approved. You should all feel robbed for this product raising the hopes of people who suffer from the skin disorder in order to make some scam artist’s pockets fatter.

  9. Kevin says:

    I have been using the Pyratine XR twice daily for 8 weeks and thus far haven’t noticed any improvement. I have mild redness but my issue is the break outs of pimples and raised areas and it hasn’t slowed the progression of that at all, if anything it seems just as bad if not worse. I will not buy anymore once my tube is finished. Still looking for something that can help me prevent the breakouts. As I said my redness is the least of my issues, it’s the breakouts. If you know of something better please tell me.

  10. Deb says:

    I have been a rosacea sufferer for years. I was proscribed metro gel which I used for years but it never really seemed to help. Still had the horrible flare ups and redness. Then a girlfriend of mine gave me a tube of pyratine XR to try that she got from her dermatologist for redness. I have been using it for two months and I have to say I’m totally amazed that I have had NO flare ups and my skin tone does seem to be much improved!I. Also I switched to Guerlain Blanc de Perle correcting UV base for sunblock. I was never without some burning and now there is non. Between the two products which are both quite expensive but they go a long way. I’m not sure if it’s totally the PyraineXR, Guerlain or the combination. All I know is, it has been a godsend for me and it it’s like I’m almost symptom free. I don’t usually write comments but if it can benefit other rosacea sufferers then it’s well worth it.

  11. Karen says:

    Well then . . . I found this product on Amazon for $20 . . . 1.5 oz – and it says it’s from Pyratine LLC and states on the tube – ‘Intensive anti-redness & healing ointment’ . . .so maybe a knockoff? All I know that it works for me – first thing that ever has. I have very bad flushing . . . and there is a noticeable difference when I use this product – from the first time I used it. It soothes the sunburn feeling I always have as well. So I hope that it keeps on working for me . . . I can only hope.

  12. It appears that those that have used the product in the above reviews are quite positive about Pyratine’s effectiveness. There are many misstatements by the author as Kinerase(R) and Pyratine(R) are not the same molecule; in fact, they are the subject of different patents and a completely different classifications of cytokinins. Both are excellent and safe products, well tested but Pyratine(R) being much more effective and faster acting. Pyratine is furfuryl tetrahydropyranyl adenine while Kinerase is N6 furfuryl adenine; Pyratine enjoys the addition of a pyranyl group in the ninth position making it much more biologically active.
    There are three published studies on Pyratine in the prestigious peer review medical journal, Drugs in Dermatology, one study being over a course of 48 weeks – note that this is a cosmeceutical, there are prescription topicals that have not been studied in a controlled clinical environment over this length of time.
    It was learned that Bad Hair Day was actually a representative for a competing company – it is a shame that someone would go to such length to smear a product that could help so many. The fact that it remains on the internet and forum is a shame but that is today’s world.
    Paula Begouin markets her own products, none of which have any clinical trials conducted at major medical centers using FDA protocols. Her comments on Kinetin are unfounded and errant. When reviewing her website for products, note that she pieces together articles on ingredients she has included in her products – this is bad science as a product must be judged in whole noting what interactions each ingredient has with another, e.g., are they antagonistic, do they increase the mitochondrial activity so greatly that they may become toxic, etc. . .This is why a product that is to be approved by the FDA must have studies done with the final formulation.
    And so that everyone knows, I am one of the discoverers of Pyratine and was the lead innovator for Kinerase/kinetin. You can reach me with your questions or comments at Thank you, Frank

  13. Gary says:

    After reading about the Pyratine XR product I ordered a trial size offered by the company. As always I was hoping the product would show at least some minor results to help my skin condition. After using it for a few days as directed I found my skin in the worse condition I had ever experienced. My skin just did not like this product. This is not to say it will not be a good product for others to use. It just did not work for me. I have super sensitive skin and am always on the lookout for a new product that works for me. I would suggest buying a trial sample size first, which was about $35 with shipping. The large size is very expensive and you might be throwing away a good amount of money if it does not work for you.

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