Some more research investigating and proving that LEDs and Low Level Light Therapy (LLLT) are good options for treating rosacea symptoms. Researchers from South Korea trialed a range of LED wavelengths from 410 nm to 940 nm and fluences ranging from 1-40 J/cm2, and measured how their usage leads to a reduction in markers that are thought to be important in rosacea.
What LEDs Colors Work Best?
This study found that LEDs in the wavelengths 630±8 nm and 940±10 nm were able to significantly alter the myriad of inflammatory markers indicated in the progression of rosacea.
For a wavelength of 630 nm, LEDs will be visible to the eye as this corresponds to the red part of the visible spectrum.
940 nm, on the other hand is getting in to the infrared part of the electromagnetic spectrum, so may not be visible to the eye. This part of the spectrum is typically used by remote control devices, such as a TV remote.
Jee-BumLee, SooHyeonBae, KiRangMoon, EuiYoungNa, SookJungYun, Seung-ChulLee
Department of Dermatology, Chonnam National University Medical School, Gwangju, South Korea
Cathelicidin (LL-37), Toll-like receptor 2 (TLR-2) and kallikreins (KLKs) are key inflammatory mediators in rosacea.
Laser or light-based devices have been successfully used for rosacea. We investigated the effects of light-emitting diodes (LEDs) on LL-37, KLKs, TLR-2 and protease activity in cultured normal human epidermal keratinocytes (NHEKs) and rosacea-like mouse skin (RLMS).
LL-37, KLK5, KLK7 and vitamin D receptor were induced by 1α, 25-dihydroxyvitamin D3 (VD3) and TLR-2 by Ad-CMV transfection in cultured NHEKs. NHEKs were subjected to LED irradiation at differing wavelengths (480–940 nm) and fluences (1–40 J/cm2).
Inflammatory mediators were analysed with RT-PCR and real-time PCR and protease activity analysis and immuno-cytofluorescence staining were performed for NHEKs. Changes in RLMS induced by LL-37 peptide were evaluated with real-time PCR, immunohistochemical staining and enzyme-linked immunosorbent assay.
In NHEKs, LEDs at 630 and 940 nm significantly attenuated LL37, KLK5 and TLR-2 mRNA expressions. Protease activity was significantly suppressed at 630, 850 and 940 nm.
In the RLMS, LL-37, KLK5 and PAR-2 mRNA expressions significantly decreased at 24 and 48 hours after LED irradiation was performed three times at 630 and 940 nm.
mCAMP and IL-8 protein levels and protease activity after LED irradiation were lower than those in RLMS control groups. LED at 630 and 940 nm downregulated TLR-2, KLK5 and LL-37 expressions and pro- tease activity in NHEK and RLMS.
Thus, LEDs may be promising for rosacea treatment. However, clinical trials are required for further study.
This study demonstrated that specific LED light irradiation down regulates cathelicidin, KLK5, KLK7 and TLR-2 expressions and protease activity, which are the main components in the pathogenesis of rosacea, both in vitro and in vivo. In our study, specific LED light with wave lengths of 630±8 and 940±10 nm (visible and near infrared, respectively) significantly suppressed the levels of cathelicidin, KLK5, KLK7 and TLR-2.
In this study, it was demonstrated that irradiation with specific LEDs with wavelengths of 630±8 and 940±10 nm out of LED with various wavelengths down regulated the expressions of TLR-2, KLKs, cathelicidin and the activity of protease – all of which are key factors well known to be involved in rosacea pathogenesis on the basis of in vitro and in vivo experiments.
Therefore, LEDs with specific wavelengths might be a promising tool for relieving the symptoms of rosacea, even though clinical trials for rosacea patients are necessary in the future.
Recently, LLLT using LED was introduced for the treatment of many conditions such as inflammatory skin conditions, wound healing and wrinkles.
Although the mechanism underlying its effect is not fully understood, it is thought to be mediated by photon absorption of mitochondrial chromophores and photoacceptors in the plasma membrane of cells, resulting in alteration of the cellular redox state and the affinity of transcription factors related to cell proliferation, tissue repair and regeneration.
In this study, LLLT with LED downregulated TLR-2 and cathelicidin, an AMP that plays an essential role in the skin barrier.26 Consequentially, it might attenuate inflammation and angiogenesis by modulating the immune response through TLR-2 and cathelicidin.
Red and Infra-Red Results
What success have you had with treating your rosacea with red or infra-red LEDs?
This study should lead to more LED treatment arrays that we can be confident will benefit rosacea symptoms.
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