Promiseb even better than Desonide 0.05%

Written by on November 26, 2009 in promiseb, seborrheic dermatitis, steroids with 4 Comments

Promiseb Topical Cream has been found to be as effective as desonide cream 0.05% when treating facial dermatitis. This is an exciting finding, especially if the results can be replicated at large in the rosacea / seborrheic dermatitis community.

Rosacea sufferers are well advised to be careful with any form of steroids because it has been shown that even over the counter steroids can cause steroid induced rosacea.
Those using the Promiseb Cream, who experienced cleared symptoms after 14 days, were more likely to stay clear for another 14 days after ceasing, compared to the Desonide Cream. This result is encouraging as it suggests that the benefit from Promiseb is more sustainable compared to even low strength topical steroids. Thus it seems from this study that Promiseb is indeed a better treatment than Desonide for mild to moderate seborrheic dermatitis.

Promiseb Topical Cream (Sebclair) is a non-steroidal, prescription only cream for the treatment of seborrheic dermatitis. It has demonstrated anti-inflammatory and anti-fungal properties. Sebclair is approved for use in the European Union to treat seborrheic dermatitis. One of Sebclair’s (and now Promiseb’s) claims to fame is that it contains no corticosteroids or immunomodulating agents.

The ingredients of Sebclair are listed here: Sebclair for seborrheic dermatitis. See also the Promiseb Prescribing Information.

An investigator-blind, randomized, 4-week, parallel-group, multicenter pilot study to compare the safety and efficacy of a nonsteroidal cream (Promiseb Topical Cream) and desonide cream 0.05% in the twice-daily treatment of mild to moderate seborrheic dermatitis of the face.

Clin Dermatol. 2009 Nov-Dec;27(6 Suppl):S48-53., Elewski B.

The treatment of seborrheic dermatitis includes topical antifungal agents to eradicate Malassezia spp, corticosteroids, which treat the inflammatory component of the disease and keratolytics which remove scale and crust.

This study compared the efficacy of a nonsteroidal topical cream and a low-potency topical corticosteroid for the treatment of mild to moderate seborrheic dermatitis of the face in 77 volunteers randomized to twice-daily treatment with nonsteroidal cream or corticosteroid cream for up to 28 days. If the individual was rated clear by day 14, the study drug was collected and the participant was told not to use any topical products on the previously treated areas until after the 28-day follow-up visit.

Both treatments were similarly effective in reducing disease severity, with approximately 90% of participants clearing or almost clear during the study. Both treatments demonstrated significant reductions in erythema, scaling, and pruritus (P < .0001). Safety in both groups was rated as excellent in more than 90%.

Those using the nonsteroidal cream who cleared after 14 days of treatment were more likely to remain clear than were participants using the corticosteroid cream (P = .0173). [my emphasis]

Investigator global assessments of improvement found both study agents were essentially the same, and participants in both groups achieved clinically important improvement.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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4 Reader Comments

  1. andy smith says:

    Great news, I suffered from ild dermatitis on my nasal labial folds for years, recently through improved diet and non foaming face wash’s Ive controlled it, but I did try hydrocortizone for a week, although I may add my rosacea was around before being prescribed.

    On a different note can I just add that I discovered this site about 3 weeks ago and have to say it is excellent and kudos to the creator/creators. No other website is as comprehensive on all subjects as this, together hopefully we will find an all inclusive treatment for all symptoms and hopefully in the near future a cure.

  2. andy smith says:

    P.s is there a forum or email address we can contact to chat about symptoms ideas, products etc with the webmaster of the site, interestingly I had a theory for years that severe to strong sunburn may have a link to rosacea, noting the burn pattern of someones face when they have redness from sunburn and the common areas of rosacea, the two seem to be linked. It’s interesting my rosacea occurs on the higher ridges and contours of my face most susceptibil to burning

  3. Hi Andy,

    Take the link at the top to “community” and you’ll find an online forum of fellow rosacea sufferers.


  4. Texas Reader says:

    My experience is the same as indicated in this study – Desonate didn’t work nearly as well for me as Promiseb and I like having a medication I can use every day without worrying that it will thin my skin (steroids do that and Promiseb doesn’t contain a steroid.)

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