So called low dose doxycycline, and treating rosacea has had some good research published in recent years. The treatment dose is low enough to not have antibiotic ability, but still give a therapeutic benefit. Tetracyclines have also been used successfully to treat ocular rosacea symptoms. This patent covers the ability to co-treat rosacea and ocular rosacea together.
One would think that such a patent would be obvious, but apparently “no one has disclosed the simultaneous treatment of both disorders”.
The patent application suggests several dosage regimes of non-antibiotic doses of tetracyclines.
Examples of the maximum non-antibiotic doses of tetracyclines based on steady-state pharmacokinetics are as follows: 20 mg/twice a day for doxycycline; 38 mg of minocycline one, two, three or four times a day; and 60 mg of tetracycline one, two, three or four times a day.
So here we can see what amount is considered to be “low dosage” for several antibiotics.
A brief summary of the patent ;
A method for simultaneously treating ocular rosacea and acne rosacea in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat ocular rosacea and acne rosacea but has substantially no antibiotic activity.
Update: note that this patent is owned by a VP of Collagenex, the makers of Oracea. Oracea is 40mg a day low-dose-doxycycline treatment. Collagenex claim to hold up to 6 patents related to Oracea.
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