Oracea plus Metrogel, Better than 100mg Doxycycline plus Metrogel ?

A clinical trial, sponsored by CollaGenex, is recruiting patients to see how Oracea compares to doxycycline (100mg once a day) when combined with metrogel 1%.

We can see from a Collagenex annual report that COL-101 was the name for Periostat MR, which then became Oracea.

Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens

Purpose: To compare the safety and efficacy of two treatment regimens: 1) COL-101 and metronidazole gel 1%; 2) Doxycycline hyclate 100 mg and metronidazole gel 1%

Official Title: A Clinical Trial to Determine the Effects of COL-101 Administered Once Daily With Metronidazole Topical Gel, 1% Versus Doxycycline Hyclate 100 mg Administered Once Daily With Metronidazole Topical Gel, 1% in Patients With Moderate to Severe Rosacea

This trial follows on from a 2005 paper that studied the combination of periostat and metrogel. That study concluded that combining sub antibiotic dose doxycycline with metrogel 0.75% was better than metrogel on its own.

Combining a systemic antibiotic with metronidazole has been the mainstay of rosacea treatment for several years. What we are seeing here is updates to studies since the introduction of oracea and metrogel 1%.

About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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2 Reader Comments

  1. De says:

    I have mild rosacea. I was on an 8 week study for Oracea with Metrogel. Unfortunately at week 4, I developed joint pain in my right hip and I was unable to complete the study. Joint pain is a rare side affect of Oracea, so please be careful. However, I did see results. If you don’t develop side effects then this would be something you might want to try. I now just use metrogel and it works really well for me. It does dry out my skin but I moisturize well. Hope this helps.

  2. PT586 says:

    If you suffer from Rosacea, and you’re looking for an alternative to harsh prescription medications such as Metrogel, I highly recommend the Green Tea Toxin Cleanser from Made from Earth. Metrogel does seem to dry out those tiny bumps and pustules, but it leaves my face terribly dry and aggravates the redness factor. I’ve been using the Green Tea Cleanser for a week, and I’ve already noticed an improvement in overall skin tone and texture. In fact, I saw a reduction in redness just a few hours after the first application!

    I still use Metrogel as a spot treatment for bumps, but I will NEVER AGAIN apply it to large areas of my face.

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