ocular rosacea and tear enzymes

Written by on October 17, 2005 in Ocular Rosacea with 0 Comments

Group IIA phospholipase A2 concentration of tears in patients with ocular rosacea

Acta Ophthalmologica Scandinavica. Volume 83, Issue 4 Page 483-486, August 2005

Kari O, Aho VV, Peltonen S, Saari JM, Kari M, Maatta M, Collan Y, Saari KM, Department of Allergology, University of Helsinki, Helsinki, Finland.

Purpose: To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with ocular rosacea, and to compare it with GIIAPLA2 concentration in tears of age-matched healthy controls.

Methods: The GIIAPLA2 concentration in tears was measured with a time-resolved fluoroimmunoassay in 21 patients with ocular rosacea (mean age 55.6±9.2 years) and in 21 normal subjects (mean age 53.4±8.2 years). Conjunctival brush cytology was carried out and eosinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithelial cells, metaplastic changes and goblet cells were calculated separately.

Results: The GIIAPLA2 concentration in tears was statistically significantly lower in patients with ocular rosacea (31.0±18.4 µg/ml, p=0.0099) and, more specifically, in patients who had dry eye (25.8±15.1 µg/ml, p=0.0034), compared to that in normal controls. There was no correlation between the GIIAPLA2 content of tears and the conjunctival cells collected by the brush cytology.

Conclusion: The tears of patients with dry eye symptoms due to ocular rosacea have decreased GIIAPLA2 content. The pathogenic importance of this finding is discussed.

Read more about: Ocular Rosacea

About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

Follow Rosacea Support

Subscribe via RSS Feed Connect on Pinterest Connect on Google Plus

Leave your comment here

Top

Subscribe to Rosacea News

Enter your email address to receive the latest news about rosacea in your inbox.