NRS Announces 2012 Research Grants

Written by on November 28, 2012 in National Rosacea Society, research foundation with 1 Comment

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The National Rosacea Society has announced 5 new research grants for 2012.

1. Identify Inflammation-causing Enzymes

Dr. Anna Di Nardo, associate professor of medicine at the University of California-San Diego, was awarded $25,000 to study the role of mast cells as a possible link between an overabundance of the antimicrobial peptides called cathelicidins in individuals with rosacea and the inflammation that appears on rosacea skin. Dr. Di Nardo will endeavor to identify inflammation-causing enzymes that are produced by mast cells as well as the influence of neuropeptides on the formation of these key enzymes.

2. Potential Genetic Factors

Drs. Meg Gerstenblith and Daniel Popkin, assistant professors of dermatology at Case Western Reserve University, were awarded $10,000 to study the incidence of rosacea in fraternal and identical twins, recruited at the annual Twins Day festival in Ohio. The study aims to document potential genetic factors by determining if there is a statistically significant difference in the correlation of rosacea between identical and fraternal twins.

3. How Kallikreins Enzymes Contribute to Inflammation

Drs. Ulf Meyer-Hoffert and Thomas Schwartz of the Department of Dermatology, University Clinic Schleswig-Holstein, were awarded $20,000 to study whether and how kallikreins, enzymes that contribute to inflammation in rosacea, can activate cytokines, which might contribute to the disease activity. The investigators will also research inhibitors of this substance that could have the potential to treat the disease.

4. Evaluate Microbes in Rosacea Patients

Dr. Barbara Summerer, postdoctoral research fellow in dermatology at Johns Hopkins University School of Medicine, was awarded $25,000 to use sophisticated analytical technology to evaluate specific microbes in rosacea patients. She will further use epifluorescence microscopy to identify possible biofilms — communities of bacteria that adhere to surfaces — that may exist in rosacea patients, as well as the differences in types of bacteria present in subtype 1 (erythematotelangiectatic) rosacea and subtype 2 (papulopustular) rosacea, so that therapy can target these bacteria.

5. Enhancing the Production of Human beta-defensin 2

Dr. Yoshikazu Uchida, associate research dermatologist, and Dr. Peter Elias, professor of dermatology, at the University of California-San Francisco, were awarded $20,000 to study whether and how enhancing the production of human beta-defensin 2 and conversely suppressing the production of cathelicidin antimicrobial peptide, part of the body’s innate immune system, may help suppress the excess of inflammation-causing peptides found in rosacea skin.

Ongoing Funding

The NRS is also continuing to fund studies by Dr. Richard Granstein at Cornell University on the potential role of Th17 cells in rosacea and Dr. Edward Wladis at Albany Medical College on identifying cytokines involved in ocular rosacea.

Donate to Further Research

If you would like to make a donation towards more medical research grants being directed towards Rosacea, please go to: How to Donate to the Society

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. Anita T. Monroe says:

    Those grants are good news. If any of the researchers needs candidates for research, I have had this skin condition since 1964. I will be willing to be studied.

    Regards,
    Anita T. Monroe
    RubatoATM@gmail.com

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