More on the GST Supergene Family

Written by on July 31, 2006 in Is Rosacea Genetic?, research with 1 Comment

Thanks to Dan for pointing out (after seeing the recent rosacea news article a genetic marker for rosacea ?) that glutathione S-transferase (GST) gene polymorphism has also been linked to other inflammatory diseases such as multiple sclerosis, alzheimers, colorectal cancer and even male infertility. As you can see from this snapshot of published studies there is a lot of research activity around this `supergene family’. Just how much can we read into a causative link between oxidative stress, a marker in the genome that indicates how our body might respond and all these conditions ?

Further, what does this mean for rosacea ? It is hard to say at the moment. Great to see that rosacea is being included in the list of diseases to try to trace in the genome. What is obvious is that there is a long way to get before useable results emerge.

Glutathione S-transferase polymorphisms in MS. Neurology 2000;54:552

The glutathione S-transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress.

Our results suggest that long-term prognosis in MS is influenced by a genetically determined ability to remove the toxic products of oxidative stress.

Glutathione S-Transferase Polymorphisms and Colorectal Cancer Am J of Epidemiol 2000 Jan 1; 151(1): 7-32.

Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer. 2005 May;41(7):980-9.

Increased Cardiovascular Morbidity and Mortality in Type 2 Diabetes Is Associated With the Glutathione S Transferase Theta–Null Genotype (Circulation. 2005;111:2927-2934.)

Conclusions: Genetic absence of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with type 2 diabetes.

Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study. Carcinogenesis 2005 26(4):811-819

The Association Between Glutathione S-Transferase P1, M1 Polymorphisms and Asthma in Taiwanese Schoolchildren. Chest. 2005;128:1156-1162

Read more about: Is Rosacea Genetic?, research

About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. Rina says:


    Is it safe to take glutathione with doxycycline or oracia?
    Thank you in advance 🙂

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