What is metronidazole ? well scientifically it is a white to pale yellow crystalline powder. Metronidazole is a member of the imidazole class of anti-bacterial agents and is classified as an antiprotozoal and anti-bacterial agent.
When taken orally, metronidazole is known as flagyl. Flagyl is used for a wide variety of infections including those in the adbomen, bones, joints, nervous system, respiratory tract, skin, as well as vaginal and intestinal infections.
A bit of history
Curatek Pharmaceuticals developed and submitted the New Drug Application for Metrogel in 1988. Since its introduction by Curatek, MetroGel has become the most widely prescribed therapy in the United States for rosacea. In 1993 Curatek Pharmaceuticals sold metrogel to Galderma Laboratories. Galderma has since introduced other variants of Metrogel, namely MetroLotion and MetroCream. Galderma is also an interesting company for rosacea sufferers because they have purchased Collagenex, who are developing a product we know as sansrosa.
Curatek, continued to market MetroGel-Vaginal (metronidazole vaginal gel, 0.75 percent) for bacterial vaginosis. MetroGel-Vaginal was introduced in the U.S. in 1992.
How does metrogel work ? well amazingly after all these products have been marketed and many studies done, the mechanisms by which metronidazole acts in reducing the inflammatory lesions of rosacea are in the main unknown.
Metrogel was responsible for generating sales of about $75 million in 2004.
In July of 2005 Galderma announced that 1 percent metrogel had gained FDA approval. The vehicle is a water-based formulation and contains no alcohol. The formulation was `enhanced with HSA-3′. HSA-3 is described as a combination of ingredients including betadex, niacinamide (vitamin B3), and propylene glycol.”
METROGEL (metronidazole gel), 1% is an aqueous gel; each gram contains 10 mg of metronidazole in a base of betadex, edetate disodium, hydroxyethyl cellulose, methylparaben, niacinamide, phenoxyethanol, propylene glycol, propylparaben and purified water.
So Why all the “Metro” products ?
Despite quite a lot of activity in the marketing and development of the metronidazole treatments (lotion, cream, gel, generic equivalents, nortitate 1%, metrogel 1%, once per day, twice per day etc) this particular research paper Metronidazole in the treatment of rosacea: do formulation, dosing, and concentration matter? suggests that the different formulations and treatment frequency make little difference to the treatment outcome.
Thus if you are already using one formulation of metronidazole, changing to another gel/cream vehicle doesn’t appear to be able to offer any additional benefits.
Does Metrogel help with the Redness?
Officially, Metrogel is only indicated for the papules and pustules of rosacea – this is what it was tested against. Some users of Metrogel do find a reduction in redness as a result of the anti-inflammatory actions of metronidazole, but you should probably consider this a bonus rather than a given.
Some of the more interesting published papers on rosacea and metrogel, and other metronidazole treatments include ;
Metrogel Savings Coupon
Galderma offers a Savings Coupon for Metrogel 1% that functions as a Co-pay Card, allowing you to pay no more than $15 when refilling your prescription. You pay no more than $15 if you have insurance, that is.
The savings coupon only applies the Metrogel 1% 55gm Pump.
The coupon is actually called the `METROGEL 1% Pump Advantage Card’ and can be found here: http://www.metrogel.com/savings-support.aspx
Questions You Want Answered
Please leave a comment below if you can help your fellow rosacea sufferer answer any of the following quesionts.
- How Long Does Metrogel Take to Work?
- Should I put Metrogel before or after Moisturizer?
- Is Metrogel better than Finacea?
- How does Metrogel Work?
Also known as Metrosa and Rozex
There are some slight variations in the actual product name for metronidazole based products around the world. You may come across references to Metrosa and Rozex. These contain the same active ingredient as Metrogel, but the overall formulation may vary slightly. In general they will all offer the same potential benefit to rosacea suffers – that is, one formulation is most likely to offer the same benefit to the lumps and bumps of rosacea as another.
- Galderma: 1 percent metrogel prescribing information
- So just How Does Metrogel Work ?
- 1 Percent Metrogel from Galderma
- Generic Metrogel soon Fougera
- Metrogel less irritating than Finacea
- Periostat and metrogel better than Metrogel alone
- Rosac Cream vs. Metrocream
- Galderma wants to own the Rosacea Market
- Metrogel 1% Pump; for those who don’t like a Tube?
- Oracea and Metrogel FREE for low income no insurance
- Metrogel also works for Seborrheic Dermatitis