Melanotan (Epitan) offers sun protection for fair skin individuals

Written by on March 8, 2006 in melanotan with 20 Comments

The following recently published article confirms that melanotan is showing promise as a sun protection for people with fair skin who normally burn in direct sunlight. It may be a long time before melanotan (or afamelanotide) is available easily around the world. This paper at least gives us some hope that it might be proven useful in the population at large rather than just sufferers of rare skin diseases.

Melanotan, [Nle4, D-Phe7]-a-MSH, significantly increased pigmentation and decreased UV damage in fair-skinned white volunteers, Ross Barnetson, MD, Sydney University, Sydney, NSW, Australia

Epidermal melanin can reduce some of the effects of UVR, which is the major cause of skin cancer. To examine whether induced melanin can provide protection from sunburn injury, we recruited 79 subjects into a clinical trial with the potent synthetic melanotropin Melanotan, delivered by subcutaneous injection into the abdomen at 0.16 mg/kg for three 10-day cycles over 3 months. Sixty-five subjects completed the trial and, compared with placebo, the skin melanin density, measured by reflectance spectroscopy, increased significantly in all Melanotan-treated subjects. The highest increases were seen in those volunteers with the lowest baseline skin melanin levels. In subjects with a skin type associated with a low MED at baseline, melanin increased by an average of 41% (from 2.55 to 3.59, P<.0001 vs placebo) over 8 separate skin sites, compared with only 12% (from 4.18 to 4.70, P <.0001 vs placebo) in subjects with a high MED skin type. Epidermal sunburned (apoptotic) cells resulting from exposure to 3 X an individual’s MED exposure of solar-simulated UVR were reduced by more than 50% after Melanotan treatment in the volunteers with low baseline MED. DNA damage, in the form of thymine dimer formation, was also shown to be reduced by 59% (P < .0033) in the basal layer of the epidermis of this group of subjects. This study has shown for the first time the potential ability of a synthetic hormone that augments melanin production to provide photoprotection to people who normally burn in direct sunlight.

Author disclosure: Consultant to Epitan Ltd. 100% sponsored by Epitan Ltd, Melbourne, Australia.

Poster Discussion Session P2621, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.

Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3. JAAD Poster Abstracts Online (29Mb)

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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20 Reader Comments

  1. clare says:

    hi i want to buy this epitan where can i purchase it?

  2. Unfortunately as these products are still in development, it is not so easy to get hold of them. They are aren’t approved for use by the FDA so you need to get hold of it through other means. I’d caution that there all the side effects and doses etc. aren’t nailed down so it is a risk you would need to be willing to take.


  3. clare says:

    how do i get it through other means???

  4. Leanne okpovie says:

    I would like to find out how and where to buy melanotan and the prices.

  5. Susan says:

    Is there a way to become part of the testing?

  6. In general there is no way to join clinical trials externally. Some trials get posted on and solicit local participants – but mostly the trial organisers go out and seek their own participants. Sometimes we hear that local doctors are used to recruit patients of a particular type, but that seems pretty rare.


  7. ann miller says:

    I have been interested in this treatment for many years since conception and as I am Scottish blue/white living in a tropical climate I would greatly appreciate some assistance as 5 mins in the sun and & I’m burned so although cautious I would like to try this product so please advise asap. thanks

  8. Nicola says:

    I am very interested in purchasing this product as i have fair hair and skin that burns easy,i also had a small skin cancer taken off last year,to weigh it up the use of a drug (eg alcohol/epitan) against bottles of tanning solution containing numerous chemicals or spray tans that are also breathed in,the epitan is more apealing.Could you please keep me updated asap when it is available to purchase as i don’t want to wait until i have to get it on prescription many thanks.

  9. Robyn Boschker says:

    I would appreciate if you could please let me know when/where I can purchase epitan/melanotan in Australia and also the cost.

    Thank you 🙂

  10. Carolyn o' donnell says:


    I would love to try this product, im tired of looking transparent. Where/who would be safest to purchase this product?

    Tank you x

  11. Andrea says:

    Hi, can you please tell me where I can purchase epitan/melanotan from in Australia? Thank you

  12. melanotan says:

    Buying and trying new products in the market is not bad but don’t be fooled by their fake promises. I suggest that before you try a particular product, any kind of products, just make sure that it is safe to use and also to our health. Because as we all known, not all products guaranteed us that their products don’t have side effects.

  13. Tanner says:

    I have been waiting for this product for some time now.
    So help me out on this guys, where can i get this product.

  14. belinda clark says:

    hi everyone ,iv just started to use melanotan ll & have been on it for approx 2 weeks,i can not believe im getting a tan,iv always struggled with this as i have fair frecklly skin & also love long days on the beach so this product is a dream come true for can get this product on the internet from a few sites but let me just tell you as ive done a little research (only after already purchasing) that i recommend you buy one that is 99% pure that has no MANNITOL OR FILLERS,i found one site that sells this. try MELANOTAN EUROPE or i get mine from PURE MELANOTAN . iv only just emailed them to see if the one i purchase is 99% pure,it does say it is but just double checking for piece of mind,also a really important thing is it can only be self injected with a needle in your tummy ,so if your no good with needles, there is another way with a nosal spray too ,but not real sure how affective this is as theres not much info on it.i hope this helps

  15. belinda clark says:

    also ,would like to add these products are not legal in most countries yet so make sure you do your research & make up your own mind weather its worth the risk,for me it was because if this product can prevent me from getting skin cancer im sold.

  16. belinda clark says:

    follow up from my last comment pure melanotan is 99% pur but hey just sent an email to me stating that if your oldere has to go thru customs you have to have script from your doctor so im going to try & get it from a local supplier

  17. belinda clark says:

    hi andrea you can get melanotan from MELANOTAN EOROPE they have a supplier in australia

  18. orla keogh says:

    Hi I live in Canada, I have the fairest of fair skin and get so jealous when I see people with dark skin. I would just love for once to Tan in the sun with out the risk of Cancer.Please I have researched Melanotan 2 since the last eight years and when I see the site all about Melanotan its on Yahoo and it feels not right to order can someone please come back to me an let me know can I order this.
    Thank you so much.
    Regards Orla.

  19. Hi Orla,

    There is nowhere in the world that Melanotan has been approved as a treatment. If you order a bottle of peptides over the internet you have no way of knowing the quality or safety of what you are getting or indeed what dose is safe for you or what to do about side effects.

    It is far safer to wait for it to become approved and try is as something like Scenesse – should that ever become approved as an aesthetic therapy.


  20. Stephen Potts says:

    I am a prime candidate for skin cancer so I would love to be kept updated on the development of this product.

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