Medicis readies to trial Ziana for rosacea

Written by on January 17, 2009 in Acne Treatments, clinical trials, Rosacea Topicals with 4 Comments


Just posted on the database is an entry “Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea”. This topical product, known as Ziana, is currently approved for the treatment of acne.

Ziana is manufactured by Medicis who also make Plexion and Solodyn. The combination of tretinoin and clindamycin may be too harsh for some rosacea sufferers, so it will be interesting to see how the trial pans out. Ziana is marketed as the only topical to combine an antibiotic and a retinoid.

The trial will primarily measure a reduction in the count of papules and pustules from baseline to week 12. A secondary measurement will be transient redness. We can deduce from this that Ziana is only thought to be effective against the inflammatory lesions of rosacea, and will likely only have a mild effect on the redness.

Rosacea sufferers have many choices to treat papules and pustules, so sufferers may well be left wondering, why one more ? If you can’t tolerate metrogel, metrolotion, metrocream, noritate, topical clindamycin, finacea or plexion (just to name a few), then maybe, at a stretch, Ziana might offer you another viable option.

Have you tried Ziana for your rosacea ? How did you find it ?

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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4 Reader Comments

  1. Ben says:

    More of the same from the medical community. The last thing the rosacea world needs is more P&P treatments, while those with flushing and redness would give their right arm for a good medication, and yet no products.

  2. Ben says:

    Medicis is also the maker of Solodyn, as mentioned in the article, the absurdly expensive antibiotic sometimes used for rosacea. Let’s see, should I take a perfectly effective $5 doxycycline or $450 Solodyn pills? (these are based on what the drug store was actually going to charge me for each…)

  3. One does have to wonder if there is room in this market for another topical … maybe it will help some, I guess.

  4. Nancy B says:

    I am 52 years old and about 6 months ago towards the end of summer, I had inflamatory bumps on my nose. I went to a dermatologist and she prescribed Ziana. I have been using it for almost 3 months now, and I’m sorry to say it did not help at all.

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