Kinetin & Niacinamide for Anti-Aging

Written by on December 14, 2007 in pyratine, Rosacea Moisturizer, Rosacea Topicals with 1 Comment

This study shows that kinetin and niacinamide work together well to provide anti-aging effects for asian skin.

Previous studies that have been highlighted by Rosacea News have also shown that topical kinetin is a good anti-aging moisturizer for rosacea sufferers and may even show some benefit for rosacea symptoms.

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.

J Cosmet Dermatol.
2007 Dec;6(4):243-9. Chiu PC, Chan CC, Lin HM, Chiu HC. Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, and Center of Anti-aging and Health Consultation, National Taiwan University Hospital, Taipei, Taiwan.

Background: Kinetin and niacinamide are used in the cosmetic industry as anti-aging agents. Neither the interactive/additive effects of these compounds nor the anti-aging efficacy on Asian skin has been studied.

Objective: To assess the clinical anti-aging effects and efficacy differences between kinetin plus niacinamide and niacinamide alone vs. vehicle placebo in an Asian cohort.

Methods: Fifty-two Taiwanese subjects were enrolled in a randomized, double-blind, placebo-controlled, split-face comparative study. Group 1 subjects were treated with kinetin 0.03% plus niacinamide 4%, whereas group 2 subjects received niacinamide 4%. The treatment formulation was applied on one side of the face, whereas a placebo was applied on the other for a period of 12 weeks. We used noninvasive biometrological instruments to evaluate a variety of skin parameters at baseline and at weeks 4, 8, and 12.

Results: Persistent and significant reductions in spot, pore, wrinkle, and evenness counts were found at weeks 8 and 12 in group 1. A significant increase in corneal hydration status was also evident at week 12, whereas persistent decreases in erythema index were apparent at 8 and 12 weeks. In group 2, significant reductions in pore and evenness counts at week 8 and wrinkle counts at week 12 were noted.

Conclusion: We found kinetin and niacinamide exert a synergistic anti-aging effect. Our data suggest that these compounds have multiactive, multifunctional, and pluripotent effects on skin. They are also both promising to be included in the cutaneous anti-aging cosmeceuticals in the future.

Have you tried Kinerase or any other topical that contains Kinetin ? What did you think of it ? Leave us a comment below.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. nicole says:

    I have been using the kinerase ultra rich night cream and while I am not less red, I am not irritated either after a week of use. As other suffers know sometimes finding products that will not irritate can be a battle in and of itself. I will continue to use it and will give an update in a few months.

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