Just how does Finacea work ?

I’m not sure that I have laid awake at night wondering about how exactly finacea does it’s thing, but as Rosacea News had a stab at Just how does metrogel work ? a while ago, an attempt at covering Finacea’s method of action is only fair.

It is interesting to consider how finacea works especially if that knowledge might lead to further understanding of how rosacea is caused or how it progresses.

This paper has identified the way in which Finacea is able to suppress the skin inflamation associated with exposure to Ultraviolet B radiation.

There may of course be other ways that finacea is able to help rosacea symptoms but this particular one has been proven by this research.

Decrypting the terminology

Before we try to pull this abstract apart, lets look at a few of the important terms.

  • A keratinocyte is a type of skin cell. The primary function of which is to form a layer of keratin that protects the skin and tissue underneath from the sun and water loss.
  • PPARgamma stands for Peroxisome Proliferator-Activated Receptors, and is a type of protein that interacts with the human gene.
  • abrogate means to annul or abolish.
  • modulate means regulate or adjust

So the conclusion of this study was that they were able to find the reason that Finacea was able to adjust the inflammatory response in the skin caused by the inflammatory response as a result of exposure to ultraviolet B radiation.

Azelaic acid  modulates the inflammatory response in normal human keratinocytes through PPARgamma activation, Exp Dermatol. 2010 Jun 2.

Azelaic acid (AzA), a nine-carbon dicarboxylic acid, is an agent for the topical treatment of acne. It has also been shown to be effective in rosacea; however, the mechanism of action has not been clarified. Because inflammation is a common feature of both conditions, we investigated the effects of azelaic acid on the inflammatory response of normal human keratinocytes to ultraviolet B light, which is a photosensitizer agent in rosacea.

AzA, at 20 mM, a concentration achievable following topical application of a 15% gel, suppresses ultraviolet B light-induced interleukins-1beta, -6 and tumor necrosis factor-alpha mRNA expression and protein secretion. Mechanistically, azelaic acid significantly reduced the ultraviolet B light-induced nuclear translocation of nuclear factor kB p65 subunit and the phosphorylation of the p38 mitogen and stress-activated protein kinase. Moreover, as peroxisome proliferators-activated receptor gamma, (PPARgamma) which has a crucial role in the control of inflammation, is activated by fatty acids and products of lipid peroxidation, we further investigated the effect of azelaic acid on the expression of this nuclear receptor.

AzA induced peroxisome proliferators-activated receptor-gamma mRNA and its transcriptional activity.

The PPARgamma antagonist GW9662 abrogated the inhibitory effects of AzA on the UVB-induced pro-inflammatory cytokines release and on the cell proliferation.

Our study provides new insights into the molecular mechanisms of the activity of azelaic acid and lands additional evidences for its therapeutic effects on inflammatory skin diseases, such as rosacea.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. Lauren says:

    Finacea is absolutly awsome! I started using it the end of June of this year, my rosacea cleared up completely!
    I still have a little redness but it’s faded and I have no scars from the previous acne rosacea like pimples I had and no pits :]. I love it so much, and it works great.

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