Ivermectin is a very useful drug indeed

Written by on January 20, 2016 in Ivermectin, Soolantra (Ivermectin Cream 1%) with 6 Comments
Rosacea sufferers have become increasingly familiar with Ivermectin in recent years since the development of the rosacea treatment Soolantra.

Clinical trials first came to rosacea sufferers’ notice in 2006 when trials started for CD5024 in Australia. The slow research and development process saw this active molecule formulated into a 1% cream, trialed extensively and then approved by the FDA in 2014. Soolantra is now widely available around the world.

What is Ivermectin?

Ivermectin is a medication that is effective against many types of parasites. It is used to treat head lice, scabies, river blindness, strongyloidiasis, and lymphatic filariasis, among others. It can be either applied topically to the skin or systemically via tablets.

Ivermectin won a Nobel Prize for Medicine

The highest award possible for medicine  – the Nobel Prize was awarded in 2015 to the inventors of Ivermectin – William C. Campbell, Satoshi Ōmura. The prize was awarded for “discoveries concerning a novel therapy against infections caused by roundworm parasites”.

The Nobel Prize in Physiology or Medicine 2015

William C. Campbell, Satoshi Ōmura, Youyou Tu

The Nobel Assembly at Karolinska Institutet has today decided to award

the 2015 Nobel Prize in Physiology or Medicine

with one half jointly to

William C. Campbell and Satoshi Ōmura
for their discoveries concerning a novel therapy against infections caused by roundworm parasites

and the other half to

Youyou Tu
for her discoveries concerning a novel therapy against Malaria

Diseases caused by parasites have plagued humankind for millennia and constitute a major global health problem.

In particular, parasitic diseases affect the world’s poorest populations and represent a huge barrier to improving human health and wellbeing. This year’s Nobel Laureates have developed therapies that have revolutionized the treatment of some of the most devastating parasitic diseases.

Difference between Avermectin and Ivermectin

Campbell and Omura were awarded the nobel for their work in discovering Avermectin. This discovery then lead to Ivermectin.

William C. Campbell, an expert in parasite biology working in the USA, acquired Ōmura’s Streptomyces cultures and explored their efficacy.

Campbell showed that a component from one of the cultures was remarkably efficient against parasites in domestic and farm animals.

The bioactive agent was purified and named Avermectin, which was subsequently chemically modified to a more effective compound called Ivermectin.

Ivermectin was later tested in humans with parasitic infections and effectively killed parasite larvae (microfilaria)

The impact of Ivermectin

The huge global impact of Ivermectin is further highlighted in the  nobel prize announcement details.

Today the Avermectin-derivative Ivermectin is used in all parts of the world that are plagued by parasitic diseases.

Ivermectin is highly effective against a range of parasites, has limited side effects and is freely available across the globe.

The importance of Ivermectin for improving the health and wellbeing of millions of individuals with River Blindness and Lymphatic Filariasis, primarily in the poorest regions of the world, is immeasurable.

Treatment is so successful that these diseases are on the verge of eradication, which would be a major feat in the medical history of humankind.

The discoveries of Avermectin and Artemisinin have revolutionized therapy for patients suffering from devastating parasitic diseases.

Campbell, Ōmura and Tu have transformed the treatment of parasitic diseases.

The global impact of their discoveries and the resulting benefit to mankind are immeasurable.

Kind of makes the benefits we focus on, namely eliminating papules and pustules, pale in significance a bit don’t you think?

How does Ivermectin work for rosacea?

Just how does Ivermectin exhibit superior papule and pustule clearing abilities ? We know from this paper that topical ivermectin is effective because of its

  • antimicrobial,
  • antiparasitic,
  • antibacterial, and
  • anti-inflammatory activities.

So it might not be as simple a story as `Soolantra killing demodex mites’ being the reason for Ivermectin’s effectiveness.

What does this mean for rosacea?

The publicity surrounding the awarding of the nobel prize for Ivermectin is potentially good news for rosacea sufferers. The focus of the public on a drug they have perhaps never heard on, could awaken more interest in its application across the spectrum.

I have the feeling that we are only beginning to see the benefit of ivermectin to rosacea sufferers.

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About the Author

About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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6 Reader Comments

  1. Sylvia says:

    It has ‘cured’ my rosacea after my doctor has had me try every other medication available over the last 8 years.

    • John says:

      Me too. Done the lot! Been using Finacea for 8 years but has been becoming less effective. 3 weeks ago switched to an Obagi foaming cleanser and Soolantra and the results are truly amazing. A whole forehead and not a spot insight skin completely clear for the first time in 25 years. Easy and pleasant to apply.

  2. Beck says:

    I’ve been on a combination of Oracea and Soolantra since early September (prior to that, just Oracea and/or doxy). With just Oracea, my p&p Rosacea was probably 85% under control, or good enough to the point where I was very happy with the improvement. But the addition of Soolantra to my daily regimen has taken my skin back to darn near what it was eight years ago before the Rosacea kicked in. I really can’t believe it. I’ve had maybe a half dozen p&p total, in five months, when I frequently had that as my “norm,” that even with the Oracea.

    I have some very minor areas of redness due to broken capillaries, and the Soolantra doesn’t help that (but neither is it meant to). I can live with that.

    Fingers crossed that I continue to have these results.

  3. Esti says:

    I find soolantra to give me black heads . I have a compound pharmacy make a ivermectin in a versabase lotion vehicle .

  4. Mandy says:

    It’s an amazing drug. Has cleared up my bumps completely. Truly remarkable. I’m so grateful. I use it every night religiously.

  5. Joe M. says:

    By the way, Ivermectin is a serious drug. Got a little on my lip, and felt like I had a
    paper cut on my lip for days.

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