How does Soolantra (topical ivermectin) work?


Ahead of the expected approval and launch of Galderma’s Ivermectin 1% Cream is this abstract further highlighting the credentials of topical ivermectin.

How does Ivermectin exhibit superior papule and pustule clearing abilities ?

Well this paper tells us that topical ivermectin is effective because of its

  • antimicrobial,
  • antiparasitic,
  • antibacterial, and
  • anti-inflammatory activities.

Galderma is expected to gain approval for their Topical 1% Ivermectin Cream this year (2014). This product has been known as CD5024 during development.

[update:] Soolantra has been approved in late 2014 – see the full list of Soolantra Articles and Soolantra Reviews.


An Emerging Treatment: Topical Ivermectin for Papulopustular Rosacea

Journal of Dermatological Treatment, November 26, 2014

Manal Abokwidir, and Alan B. Fleischer, Department of Dermatology, Wake Forest School of Medicine; Winston-Salem, North Carolina

Ivermectin shows broad-spectrum anti-parasitic activity. It kills the Demodex mites that reside in the pilosebaceous units of patients with papulopustular rosacea.

Ivermectin also has anti-inflammatory effects, it decreases cellular and humoral immune responses. Inflammatory mechanisms appear to play a dominant role in development of rosacea inflammatory lesions.

Additionally, there is some evidence that it has antimicrobial activity, against Myobacterium tuberculosis and Chlamydia trachomatis.

In recent clinical studies of ivermectin on rosacea show that it was superior to vehicle in reducing inflammatory lesion counts, and tolerability was excellent.

Ivermectin displays antimicrobial, antiparasitic, antibacterial, and anti-inflammatory activities.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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27 Reader Comments

  1. cescomtl says:

    Sounds promising and hopefully made available in Canada too.

  2. Elle says:

    Let’s hope this works!

  3. Yes let’s hope that this cream works,as it will be great news for all who suffer from this very annoying skin problem including me….

  4. Shelia Butts says:

    Is there any idea yet when this may be available for doctors to prescribe?

  5. Johnathan says:

    1st Quarter 2015

  6. AS says:

    Does anyone know if this will help with redness, stinging, burning or just with papule and pustules?

  7. Shelia Butts says:

    I am hopeful it will work for all symptoms but mostly breakout

  8. KC says:

    Does this mean it eill be ineffective at controlling flushing? Or is flushing caused by demodex?

  9. annabelle aponte says:

    This medication sounds great for my husband. Please keep us informed when it becomes available. The Desowen he uses twice a day is not working as well as before, and he has been getting more papules and pustules. According to what I have been reading, he may have the Demodex mites??

  10. Patryk says:

    What about flushing? It could be work?

  11. Geri Healy says:

    Why is Soolastra so expensive ($300)? Of coarse my insurance won’t cover it. Ivermectin isn’t expensive, and can be purchased at farm supply stores. Can I make my own?

  12. Annabelle says:

    Is the Ivermectin available yet???? I hope it is. I would rather pay $ 300 than the $ 600 that I paid for my husbands Oracea medication…. which in fact, I don’t see much improvement. My insurance company doesn’t pay for the medication either. Please let me know when this is on the market! Thanks

    • Soolantra will be becoming available from your doctor across the US. It will take a while for all doctors and pharmacies to find out about it and order it etc. – but it should be available to be ordered now.

  13. David H says:

    It is available now. Picked it up today at Walgreens. Out of pocket cost was $45.

  14. CKF says:

    My out of pocket was $71. I have Anthem insurance. Just got the Rx yesterday (just diagnosed with Rosacea) and used it for the first time last night. No burning or stinging, but then I only have a few bumps around/on my nose. I mostly have red blotches on my cheeks. Not sure if this med will help with those. Hope so.

  15. Susan says:

    Just started using it today. Sure hope it works!

  16. Annabelle says:

    My husband has been dealing with Rosacea for over a decade and throughout the years it has been getting worse. His face was full of papules and pustules and the Desowen he had been using forever was not doing much for him. I really would like to thank Mr. David Pascoe, for having this support group and informing people with this condition of the new medications. It is because of Mr. Pascoe and Soolantra, that my husband has a beautiful face again. His papules and pustules disappeared after eight weeks. He was ready to discontinue the medication after a few weeks because his face got really, really, bad before it miraculously got better. I told him that I had read that other people got worse before they got better. I made him hang in there and I am really glad he listened to me. He is a physician and doctors are the worst patients!! I am aware that Soolantra does not help with flushing. He still has a red face, but it is much better than having papules and pustules. God Bless Mr. Pascoe and Soolantra.

  17. Cindy says:

    Soolantra available in Canada as Rosiver. Just picked it up yesterday.

  18. Brian Sullivan says:

    Soolantra is GREAT! I’ve been using it for about 3 months and my face has been restored from the red rosecea. I’ve had rosecea for about 10+ years now and tried Metrogel and Solodyn. My face started burning with Metrogel which made my symptoms worse. My dermatologist put me on Solodyn. This worked well for a number of years. During a 2015 visit, the same doctor told me about Soolantra. I tried it and was amazed at how quickly and painlessly it brought back my natural complexion. My dermatologist said to apply it at bedtime and to spread it all over my face, not just where the red areas are. I can tell you this works 100%. Be careful to keep it away from your eyes, because it stings like hell if you get the slightest residue there. I notice a slight greasiness to my skin during the day that did not exist before using Soolantra, but it’s a small price to pay for having a nice clear face. Caffeine is also a big trigger for me. After I gave up coffee and soda cold turkey, I noticed a nice improvement in my face. That was prior to using Soolantra. Soolantra was just icing on the cake, so to speak. Soolantra’s not cheap, but with BCBS, it’s affordable.

  19. Theresa says:

    In the past I have used Metrogel which didn’t help much, if at all.
    I have been using Soolantra for the past 1 1/2 years and it is fabulous. My face was red and burned so badly and was very red before using the Soolantra. I did take Oracea at the same time which also helped a lot. Unfortunately I recently started being covered by Medicare which doesn’t cover either of these medications. So sadly, I won’t be using it any longer since the prices are out of sight.

  20. James Connaire says:

    We need a cure for red face not a major expense that we can’t afford,I have researched everything for rosacea to no avail,please doctors please find us some help and don’t rip us off with high prices.

    Red face deprives us from living our lives to the fullest,emotional scares run deep and depression from this is overwhelming and has been a lifelong battle.

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