Finacea Foam vs. Finacea Gel

This time last year we learned that Finacea Foam was being trialled for rosacea. That 2009 initiated trial was to compare Finacea Foam against the placebo foam vehicle.

Now a new trial has been listed to compare Finacea Gel with Finacea Foam.

As I noted a year ago, these kind of `swings and roundabouts’ trials tend to be seen when a product reaches maturity and the manufacturer is seeking to build their portfolio with derivative products.

This trial will be valuable because it will be able to prove if the foam delivery system is able to offer a measurable benefit to users. Note that this trial will be looking at the Pharmacokinetics of the active ingredient – azelaic acid; that is, how much of it is available in the skin for the 12 hours after application. Thus the trial will be able to provide proof that the foam delivery mechanism it more or less effective or indeed just as effective as the topical gel.

The purpose of the test also refers to “repeated application” but doesn’t detail what this means.

Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea

Investigator-blinded, Randomized, Cross-over, Multiple Dose Phase I Study on Safety and Pharmacokinetics of Topically Applied Azelaic Acid Foam, 15% Compared to Azelaic Acid Gel, 15% in Subjects With Papulopustular Rosacea.

Primary Outcome Measures:

  • Baseline corrected area under the curve (AUC) [ Time Frame: 12 hours ]

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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9 Reader Comments

  1. Ricki Welsch says:

    I just tried the finacea foam for the first time. My face turned beet red & is burning after one use. I never had a reaction to the gel. I just called my pharmacy to refill the gel. I hate that I have to throw away the foam & especially the cost is not refundable.

  2. Susan says:

    I tried the finacea foam for the first time recently & did not like the feel of it on my face. I went back to the gel which lasts about 3 months for me with daily use. I think I would have had to refill the foam in about a month. As a side note, I ended up using the remaining foam to control a severe poison ivy rash all over my body until I got a steroid script from my dermatologist. The finacea gel keeps my rosacea under control. It’s been a while since I had a severe outbreak.

  3. James Poitras says:

    If as you state “Note that this trial will be looking at the Pharmacokinetics of the active ingredient – azelaic acid; that is, how much of it is available in the skin for the 12 hours after application.” then it is wrong to assume that “Thus the trial will be able to provide proof that the foam delivery mechanism it more or less effective or indeed just as effective as the topical gel.”…..more is not necessarily better.

    And judging from the above comments, the foam may have a disadvantage in terms of irritation, and increased cost. This is just a procedure used by pharmaceutical companies to extend patents and hence increase the cost of drugs that would otherwise be subject to generic production and ideally reduced cost.

  4. Blessy Chacko says:

    My friend had less irritation with the foam. Her skin was really irritated with the gel. My doctor had first put me on epiduo forte gel which irritated my skin to a point that I could not use it. I tried the finacea foam for the first time yesterday night and today morning with no irritation so far.

  5. Melissa Esford says:

    I prefer the gel, my face was irritated by the foam. I went back to the gel and am much happier.

    • Ricki Welsch says:

      Hi Melissa, I experienced the same thing. My face was red & burning after using the foam. The gel does not cause any reaction!

  6. Nan Prather says:

    I find that the foam is more drying than the gel. Why is it called a gel when really its a cream? I like it alot better.

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