Another paper showing that the licorice extract Licochalcone A can be used to create well tolerated rosacea treatments. The rosacea community is also saying that the Eucerin Redness Relief products are working well as a part of their rosacea-beating regime.

Tolerance and efficacy of a skin care regimen containing licochalcone A for adults with erythematic rosacea and facial redness

Weber TM, Scholermann A, Burger A, Kolbe L, RJ Ceilley, Trookmann NS, Rizer RL (2005)., Beiersdorf Inc, Norwalk, CT; Beiersdorf AG, Hamburg, Germany; University of Iowa, West Des Moines, IA; Rocky Mountain Laser Center, Colorado Springs, CO; TJ Stephens & Associates, Colorado Springs, CO.

European Academy of Dermatology and Venerology, 14th Congress, London, October 2005, EADV 2005, Poster 02.51

Licochalcone A, derived from the root extract of the licorice plant Glycyrrhiza inflata, has been shown to inhibit pro-inflammatory cytokines, eicosanoids and reactive oxygen species in a number of human skin cells as well as to relieve post-shave irritation and UV-induced erythema in vehicle controlled studies.

This poster reports the compatibility and efficacy of a regimen of skin care products containing licochalcone A for individuals with rosacea and persistent facial redness. Redness concealing properties,a reduction of erythema over time, and an improvement of the quality of life are demonstrated benefits in these patients.

Objective: This was an 8-week clinical test to demonstrate the anti irritative efficacy and skin compatibility of a product regimen (Eucerin Anti-Redness) containing licochalcone A for subjects with mild-to-moderate Type I rosacea, and facial redness not attributed to rosacea.

Study Design: Thirty-two subjects with mild-to-moderate erythematotelangiectatic rosacea (1) and 30 subjects with red facial skin not attributed to rosacea were enrolled and completed the study. The subjects were female, aged 20 and 65 years ,with a mean age of 48. All of the subjects used each of the 4 test products daily. The regimen consisted of a cleanser, an SPF 15 moisturizing day care containing green concealing pigments, a cream concealer (with green pigments) and a night moisturizing cream.

Results: Subjects were photographed at the baseline visit, and at weeks 4 and 8. The lighting and photography conditions were carefully controlled and replicated at each photography session. At the baseline visit, standard light photographs were taken before and within 15 minutes of applying the SPF 15 moisturizer and cream concealer, both containing concealing pigments.

Discussion and Conclusion: Licochalcone A is shown to reduce pro-inflammatory mediators in vitro and reduce post-shave and UV-induced skin irritation. In this study,we evaluated the compatibility and suitability of a skin care regimen containing licochalcone A for patients with persistent facial redness.

After daily use for 8 weeks, the products were judged to be gentle enough for every day use and very well tolerated by the subjects. Both photographs and subject questionnaire responses showed that the green concealing pigments in the day care and cream concealer were very effective in neutralizing the appearance of redness.

At both 4 and 8 weeks, there was a statistically significant difference decrease in clinical grading scores for erythema relative to baseline. Differences in facial redness could also be observed in cross-polarized photographs. Compared to the baseline evaluation,there was a significant difference in the QOLI after 8 weeks on the skin care regimen, indicating that the subjects were less affected by their skin condition.

In summary,these results support the daily use of Eucerin Anti-Redness skin care products containing licochalcone A for patients with rosacea and facial redness.They can also be used as complimentary skincare for patients with topical metronidazole or azelaic acid.

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