Elorac promoting Carbamide Peroxide as a Rosacea Treatment

Written by on November 19, 2010 in Acne Treatments, New Rosacea Treatments with 0 Comments

Elorac

A recent press release from a company called Elorac, is highlighting Phase II trials for treating Acne with Carbamide Peroxide. Elorac are promoting Carbamide Peroxide as an improved, next-generation version of benzoyl peroxide.

Benzoyl Peroxide has not to date been commonly used as a rosacea treatment because of concerns about being too harsh for some rosacea sufferers. The preliminary results from Carbamide Peroxide suggest that it may be responsible for less skin irritation but might be just as effective as Benzoyl Peroxide.

Here is an extract of the press release from Elorac’s web site;

Elorac, Inc. Announces Clinical Results of Carbamide Peroxide Studies for the Treatment of Acne

November 18, 2010

Elorac, Inc., a rapidly growing specialty pharmaceutical company focused on the treatment of dermatological disorders, announced results of two Phase III studies of its patented Carbamide Peroxide (CPO) solution for the treatment of inflammatory acne vulgaris and rosacea at the Lazard Capital Markets 7th Annual Healthcare Conference in New York.

Jeffrey Bernstein, Ph.D., Elorac’s President and CEO, commented, “We see a great market opportunity for Carbamide Peroxide in acne and rosacea. These are large markets. Branded topical products for acne and rosacea generate more than $1 billion in sales. CPO would be the first new topical product for acne and rosacea in several years. It’s an improved, next-generation version of benzoyl peroxide (BPO), which is the most commonly used product for acne.”

In two phase III pivotal double-blind, randomized, vehicle-controlled, paired-comparison, multi-center studies, the results showed statistically significant reductions in acne lesion counts after 8 and 12 weeks of treatment with CPO as compared to vehicle treatment.

Bernstein added, “The efficacy results for CPO are similar to those of previously approved topical acne products, but CPO has a distinct advantage in its tolerability. We have, in fact, clinical data comparing BPO and CPO in acne that demonstrates comparable efficacy, but documents significantly less local skin irritation in patients using CPO. We think that this superior tolerability also bodes well for the use of CPO in rosacea, where irritation is even more of an issue.”

Carbamide Peroxide, also known as urea peroxide, is perhaps best known as a teeth whitener.

Elorac was formerly known as Exopharma, and Exopharma are listed as the owner of a related patent; Method of Treating Inflammatory Acne Vulgaris with Carbamide Peroxide. This patent application would have to be the one of the shortest text I have read ! A couple of interesting extracts.

The applicant has discovered, quite surprisingly (and in direct opposition to the teaching in U.S. Pat. No. 4,607,101) that carbamide peroxide by itself is quite effective at treating the inflammatory lesions of acne vulgaris, and acne rosacea. The invention, therefore, encompasses an improved method of treating inflammatory acne vulgaris or rosacea utilizing application to the skin of solutions, creams, gels, or lotions containing carbamide peroxide

A 48-year-old female with rosacea and four acneform papular lesions of the nose and cheeks applied the 10% carbamide peroxide solution of Example 1 to her face three times daily for eight weeks. At the end of the eight weeks her face was clear of rosacea papules.

Elorac lists in their product pipeline a product known as E-0301. This product is indicated for Acne and Rosacea, with Acne being listed as being at Phase 3 status and Rosacea at Phase 2. The projected availability dates are 2013 and 2014 for E-0301 in Acne and Rosacea respectively.

Elorac already markets the following dermatology products;

  • NicAzel for Acne. NicAzel is a dietary supplement  that is described as a “combination of ingredients shown to possess anti-inflammatory and anticomedonal activity.” The ingredients include Nicotinamide, Azelaic Acid, Zinc Oxide, Pyridoxine, Copper Oxide and Folic Acid. Interesting to see azelaic acid as an oral supplement.
  • Durasal (Salicylic Acid 26%) for Warts.
  • Zithranol-RR for Psoriasis. Zithranol is a topical cream that contains Anthranlin.

So it appears that we should add E-0301 to the list of rosacea treatments coming soon.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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