Elorac Patenting Oral Niacinamide + Oral Azelaic Acid (Finacea)

An unusual patent has surfaced that is suggesting the oral use of azelaic acid. Azelaic Acid is better known as the active ingredient in the topical finacea. This patent suggests an oral treatment that combines niacinamide with azelaic acid.

The owner of the patent, Elorac is known from their recent trials of Carbamide Peroxide as a rosacea treatment.

Finacea has received some recent good publicity via some studies that showed that Finacea was able to alter some of the elements of the way that rosacea progresses as a disease – Finacea and the Cause of Rosacea

United States Patent Application 20110256237

Bernstein; Joel E., ELORAC, INC.

Filed: April 16, 2010

METHODS AND COMPOSITIONS FOR TREATING ACNE VULGARIS AND ACNE ROSACEA

Abstract

Methods and compositions are described for treating acne vulgaris and acne rosacea by administering compositions suitable for oral administration.

Suitable compositions contain high dosages of the vitamin nicotinamide combined with much lower dosages of azelaic acid.

Some extracts;

  • [0007] Novel and improved methods and compositions for treating acne vulgaris and acne rosacea are described. High dosages of nicotinamide (aka niacinamide) ranging from 100 mg to 1000 mg per unit dose and up to 3000 mg daily were combined in formulations suitable for oral administration with much lower dosages of azelaic acid, the azelaic acid dosage ranging from 1 mg to 50 mg per unit dosage and up to 150 mg daily.
  • [0008] Formulations suitable for oral administration include tablets, capsules, caplets, and suspensions. Such oral formulations optionally include beside nicotinamide and azelaic acid, other vitamins, minerals, and nutritional ingredients, including but not limited to folic acid, pyridoxine, vitamin A, vitamin E, vitamin C, vitamin D, zinc, copper, glycyrrhizinic acid, glycyrrhetinic acid, carbenoxolone, resveratrol, and beta carotene.
  • [0009] Formulations suitable for oral administration containing 100 mg to 1000 mg per unit dose of nicotinamide and also containing azelaic acid from 1 mg to 50 mg per unit dose are administered once to four times daily as tablets, capsules, caplets or suspensions to patients with either acne vulgaris or rosacea. Such daily therapy may be provided for treatment durations of as little as 1 to 2 weeks or continuously for durations of up to several years or more.
  • [0010] The following examples are not meant to be limiting. It is possible to produce still other embodiments without departing from the concepts of the materials and methods claimed herein. Further embodiments are within the ability of one skilled in the art.
  • Example 1 . Oral tablets containing 600 mg nicotinamide, 5 mg azelaic acid, 10 mg zinc (as zinc oxide), 5 mg pyridoxine, 1.5 mg copper (as cupric oxide), and 500 mcg folic acid are administered to patients with mild to moderate inflammatory acne vulgaris once to four times daily, with a majority of such patients expected to demonstrate significant reductions in their acne lesions over treatment periods of 1 to 52 weeks.
  • Example 2. Oral tablets containing 750 mg nicotinamide, 50 mg azelaic acid, 1 mg folic acid, 20 IU vitamin A, 100 IU vitamin D, and pyridoxine 5 mg, are administered to patients with acne vulgaris once or twice daily for 12 consecutive weeks. Such patients are expected to show dramatic improvement in their acne conditions by the end of the 12-week administration period.
  • Example 3. Gelatin capsules containing 100 mg nicotinamide, 1 mg azelaic acid, 500 mcg folic acid, 100 IU vitamin A, 25 mg zinc oxide, 1.5 mg copper oxide, and 2 mg glycyrrhetinic acid are administered four times daily to patients with rosacea for from 4 up to 52 weeks of continuous therapy. Acneform lesions of rosacea are expected to decrease significantly over this treatment course without any of the systemic side effects associated with oral antibiotics.
  • Example 4. Gelatin capsules containing 600 mg nicotinamide, 50 mg azelaic acid, 10 mg zinc oxide, 10 mg pyridoxine, 500 mg folic acid, 20 mg beta carotene and 1 mg carbenoxolone administered two capsules twice daily are expected to produce impressive clinical improvement in the complexions of patients with severe inflammatory acne vulgaris.
  • Example 5. Caplets containing 250 mg nicotinamide, 5 mg azelaic acid, 100 IU vitamin A and 500 mcg folic acid are administered to patients with rosacea with the expected result that such patients will have marked improvement in their acneform lesions without any systemic side effects.
  • Example 6. An oral suspension flavored with artificial or natural fruit flavors (e.g. cherry, orange, pineapple) containing 150 mg nicotinamide and 5 mg azelaic acid in each 5 ml of liquid is administered to adolescent males or females with inflammatory acne vulgaris in a dosage of 1 teaspoonful (5 ml) twice daily with resulting excellent control of acne and no serious side effects.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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1 Reader Comment

  1. anthony says:

    i use Acnederm (azelaic acid 20%) for the postule aspect of rosacea and it is very effective. It also burns like hell but the postules are gone inside a week. Doesn’t seem to treat redness though.

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