DRx AFC Medirepair (Arazine) now available in Japan

Written by on July 12, 2010 in Sansrosa with 17 Comments


Signum Biosciences have announced that their first generation “Signal Transduction Modulator” product, AFC Medirepair (Arazine), is now officially available in Japan.

From the product web site, the product has some other related products names such as Skin Moisture Calm as well as DRx AFC Medirepair. AFC is an abbreviation for the chemical name of Arazine.

AFC Medirepair comes in a 15mL tube and retails for a MSRP 1,890 yen which is around $21 USD. Other snippets from the site suggest that it offers 8 hours of continuous moisturizing. No indication on the site if they are shipping outside of Japan.

The wonderful automatic translation of the Japanese usage instructions is “Dosage taken as a hand, please let me gently soften areas of concern.”

The ingredients listing translates to the following ;

Arazine Ingredients

Water, petrolatum, glycerin, tri (caprylate / caprate), glyceryl, squalane, sorbitan stearate, PEG-40 hydrogenated castor oil, hydrogenated lecithin, Asechirufaruneshirushisutein, TEA, soy sterol, Cetyl alcohol, coconut fatty acid sucrose, xanthan gum, carbomer, peppermint oil, BHT, EDTA-2Na, Methylparaben, Propylparaben

Here is an extract from today’s press release;

Signum Biosciences, Inc. Announces Commercial Launch of Arazine

Proprietary skincare technology platform reaches market

PRINCETON, N.J., July 12, 2010 /PRNewswire via COMTEX/ — Signum Biosciences announced that its partner, Rohto Pharmaceutical Co., Ltd., has launched AFC Medirepair with Signum’s compound Arazine (n-acetyl-s-farnsylcysteine or AFC) in Japan.

Arazine is the first compound from Signum’s novel anti-inflammatory platform to be commercialized from Signum’s pipeline of Signal Transduction Modulators (STMs).

The DRx AFC Medirepair website can be found at: http://www.drx-web.com/aa/prod_afc.htm .

"We’re excited to launch Arazine in the Japanese market providing a completely new and effective product for treating skin inflammation," said Signum president, Maxwell Stock. "The commercialization of Arazine is a significant milestone for Signum and validates our underlying business model."

Arazine is a Signal Transduction Modulator (STM) with anti-inflammatory properties, which has been developed for topical skin treatment.

STMs block inflammation and neutrophil infiltration in chronic redness, acne, skin irritation, and other skin conditions by modulating G-protein signal transduction pathways. They also act as antioxidants to neutralize free radicals and prevent UV damage, cellular degeneration and production of chemicals that cause further damage.

Arazine is closely followed by Signum’s pipeline of compounds including SIG990 which is being developed for rosacea and other inflammatory skin conditions.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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17 Reader Comments

  1. DukeCity says:

    Now to find a way to purchase it! The price is fantastic if it works!!

  2. j says:

    so dave, this is applicable to rosacea? Can you figure out a way to purchase it for americans and begin publishing reviews on it?

  3. Eric says:

    peppermint oil doesn’t sound too Rosacea friendly

  4. Eric says:

    I just called them and they said you can only get this product from a dermatologist/skin clinic in Japan.

  5. David Pascoe says:

    Thanks Eric,

    The web site indeed didn’t seem to suggest that you could order it online.

    As the product is new is makes sense that the availability is limited to begin with. It is also remembering that the actives are not yet approved to treat any condition.


    This related to rosacea because Signum are in the early stages of a related active molecule, of which they have teased us with some data about how well it treats the redness of rosacea. If, and it is a big IF, it translates to an approved and proven product, it could be a good treatment for those who struggle with this hard to treat part of rosacea.

    Everyone will note that this product, DRx AFC Medirepair is not being promoted as a treatment for rosacea, redness or anything in particular. This would be because it is not yet approved as a treatment.

    It would be great if there was an online rosacea member who was in Japan who could try it for us, but that sounds like a long shot at this stage.


  6. Mary says:

    I wouldn’t put parabens anywhere near my skin.

  7. Smitty says:

    Well….I have just about given up. After years of hearing about Nase, and now Synd…..and hearing that San Rosa still is being held hostage with no release date in site. All we have is a book called ” Banish Rosacea”. Strange enough. As I looked to see if there was anything ( like some user who would share there big secrets )…….None were found. All I have now is Oracea, and some Ketoconazole, and of course some green tinted sun block.
    I really wish I had something that really, really, worked. At this point. I am ready to give a 3 rd try st V-beam , AGAIN.
    HAs anyone tried Cucumbers for the itch??..or Clairfoam?



  8. Pablo Escobar says:


    If you’re willing to try anything, you should really consider melanotan or melanotan II. I have rosacea/kprf and the tan makes the redness very vague and it also looks great!!

  9. Pavla says:

    to Pablo Escobar – message No. 8
    1) How long are you on Melanotan ?
    2) Did you notice any side effects ?
    3) Was the progress of your rosacea stopped/worsened and what it did with teleangiectasis ?
    Than you for your reply.
    Best Regards,

  10. Pablo Escobar says:


    I’ve done about 5 cycles of melanotan II and honestly, I love it. I love being able to go to the lake and get tan like Everyone else. It blends so well with my stupid constantly red cheeks. Side effects are that it makes you very horny and not very hungry. I honestly think I have kprf and rosacea but it hasn’t stopped or cured it. It just makes it not very visible. For once in my life, I got my confidence back. But no one knows the long term affects of the drug but I feel that it is safe

  11. j says:

    When is the american release? Anyone know?

  12. Mary says:

    I have to thank whoever posted a recommendation for ZZ Cream. It’s the only thing that has ever worked to take away my red patches. Can’t quite believe it, but it’s really working.

  13. David Pascoe says:

    Development for the US release is ongoing, no updates have been made available yet. I would guess we should expect it to be many months before the company has anything to announce.

  14. DukeCity says:

    David, It’s been several months since it was released in Japan, have you heard any reviews/results from rosacea sufferers using the AFC/Medirepair???

  15. David Pascoe says:

    Sorry, no updates that I have come across.

  16. Riki says:

    Im in japan and i have rosacea im thinking about trying it.

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