Verifiable nutritional links to chronic inflammatory diseases are something that the whole rosacea community needs. This could be an important first step.
A randomized, double-blind study of a nutritional intervention in the treatment of psoriasis, Mandeep Kaur, MBBS, Steven Feldman, MD, PhD, Ann McCarty, MS, PA, Wake Forest University School of Medicine, Winston-Salem, NC, United States
Background: The cellular immune system plays a dominant role in the exacerbation of psoriasis. The digestive system (by virtue of the profile, number, and species of bacteria present at any given time) influences the status of the immune system. Bacterial pathogens influence specific cytokine activity due to the activity of super antigens. Modulation of bacterial gut flora offers a potential target for psoriasis treatment.
Methods: Approximately 40 adult male and female subjects with mild to moderate plaque-type psoriasis will be enrolled. Subjects will be randomized to take a lactobacillus nutritional supplement versus placebo once daily for 8 weeks.
Results: The primary outcome of this study is the change from baseline to week 8 (or end of treatment) in the composite score of the signs of psoriasis (erythema, scaling, plaque thickness) for target lesions. Other outcomes include Investigator’s and Subject’s Global Assessment of Response and change in pruritus score.
Conclusion: This study will be a first step to understanding the use of nutritional intervention in treatment of mild to moderate psoriasis.
Author disclosure: The Department of Dermatology has received support from Ganeden Biotech. Sponsored by the National Psoriasis Foundation.
Poster Discussion Session P2805, American Academy of Dermatology, 64th Annual Meeting, March 3-7 2006, San Francisco.
Supplement to Journal of The American Academy of Dermatology, March 2006, Volume 54, Number 3.
a good topical solution for Psoriasis is applying Corticosteroid or Retinoids on affected areas. it helps tone down the redness and scaling.