Compensatory Flushing with Mirvaso: JAMA Dermatology

Written by on June 24, 2015 in Mirvaso Gel (Brimonidine 0.33%) with 1 Comment

LEFT: Patient at initial clinic visit after 7 months of brimonidine treatment showing compensatory vasodilation and flushing in untreated areas of right lateral cheek and chest.

RIGHT: Patient 1 week after cessation of brimonidine treatment showing marked improvement in compensatory vasodilation and flushing.

A brief observation published in the Journal of American Medical Association Dermatology details a case of compensatory flushing from a long term user of Mirvaso. Compensatory flushing means that flushing has occurred somewhere that Mirvaso was not applied, but was caused itself by Mirvaso.

Erythema in Skin Adjacent to Area of Long-term Brimonidine Treatment for Rosacea: A Novel Adverse Reaction.

Gillihan R, Nguyen T, Fischer R, Rajpara A, Aires D.

JAMA Dermatol. 2015 Jun 17

We describe a case of compensatory vasodilation in the vasculature surrounding the site of long-term brimonidine use for the treatment of rosacea.

The article details a patient who presented with redness and flushing on areas of the face and neck that had not been treated with Mirvaso. Areas that were treated did show a benefit and were described as being spared from the redness present elsewhere on the face, neck and chest.

The patient had used Mirvaso for 7 months, and had followed the suggested treatment instructions.

The compensatory flushing resolved shortly after ceasing treatment with the brimonidine based gel.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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