Topical Ivermectin Patent for Rosacea

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Topical Ivermectin Patent for Rosacea

Postby Artist » Thu Jun 25, 2009 1:42 pm

Wow this looks interesting:

http://appft1.uspto.gov/netacgi/nph-Par ... 0090163568

Ivermectin kills demodex mites, which are thought to aggravate rosacea in some people. I think topical ivermectin made just for rosacea skin would be fabulous. I hope we see this one soon! I think derms downplay demodex in general, but if there were a prescription for rosacea we could try for it, I think many of them would give it a try to help their patients who don't respond as well to the typical rosacea meds.

Thoughts? David?

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Re: Topical Ivermectin Patent for Rosacea

Postby CrabbyCathy » Fri Jun 26, 2009 3:31 am

My derm was all for giving it a try, even though my skin scraping showed minimal mites, but the pharmacy compound specialist wasn't in for him to speak to, so I never pushed it. Someone on another board had fab results though; she's in Australia, I believe.
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Re: Topical Ivermectin Patent for Rosacea

Postby David Pascoe » Fri Jun 26, 2009 3:34 am

interesting that Galderma wants to mix metrogel with ivermectin to create a new rosacea treatment. Ivermectin has anti-inflammatory properties on its own, so maybe it might work for that reason as well as any possible anti-demodex properties.

"The most common hypothesis is based on the characteristic presence of the parasite Demodex folliculorum in the case of patients suffering from rosacea."

not sure that I agree with that statement - about demodex being the most common hypothesis, but I guess you want to cover all your bases when creating a product.

of course there are other patents for oral and topical ivermectin on their own.

"U.S. Pat. No. 5,952,372 also describes a method for treating rosacea using ivermectin orally or topically in order to reduce and eliminate the parasite Demodex folliculorum present on the skin of patients. "

"U.S. Pat. No. 6,133,310 describes the use of ivermectin in the treatment of rosacea in order to reduce and eliminate the parasite Demodex folliculorum present on the skin of patients. "

It is probably a good thing that Galderma is taking an interest in this - they have the backing to take such a product through clinical trials. Whether or not this kind of topical is significantly more effective than bog standard metrogel we'll have to see.
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Re: Topical Ivermectin Patent for Rosacea

Postby CrabbyCathy » Fri Jun 26, 2009 4:00 am

Want it!
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Re: Topical Ivermectin Patent for Rosacea

Postby David Pascoe » Fri Jun 26, 2009 6:55 am

I thought ivermectin patents seemed familiar. I put an item in Rosacea News in 2006 after finding a few patents filed. None of these talk about combining with metronidazole though.

some of these are starting to look old now.

http://rosacea-support.org/ivermectin-patents.html

Method of treatment of rosacea
Patent Number: 6,133,310
Inventors: Parks; L. Dean (Ocala, FL)
Filed: August 26, 1999
A method of treatment of acne rosacea consists of the application, in the form of either a lotion or a cream, constituting a mixture of a therapeutically effective amount of invermectin in water, in the case of the lotion, and invermectin and a pharmaceutically acceptable carrier, in the case of the cream. Application to the affected area occurs daily for a period of one week and, thereafter, two to four times per month for a period of up to one year.

Method of treatment of seborrheic dermatitis
Patent Number: 6,433,006
Inventors: Parks; L. Dean (Ocala, FL)
Filed: October 12, 2001
A method of treatment of seborrheic dermatitis includes the application, in the form of either a lotion or a cream, of a mixture including a therapeutically effective amount of ivermectin in water preferably in a concentration of about 750 micrograms per milliliter (mcg/ml), in the case of a lotion, and with a pharmaceutically acceptable carrier if used as a cream. Such a lotion or cream is applied nightly preferably for a period of seven days and then employed on a maintenance basis one to four times per month.

Method for treating rosacea using oral or topical ivermectin
Patent Number: 5,952,372
Inventors: McDaniel; William Robert (Brentwood, TN)
Filed: September 17, 1998
A method of treating rosacea in humans involving orally-administered or topically-applied ivermectin is disclosed. More specifically, oral ivermectin in a regimen of 200 micrograms per kilogram body weight per dose for 2 or 3 consecutive doses at least 3 and not more than 7 days apart as the preferred regimen or, alternatively, topical ivermectin compounded to a 2% concentration by weight in a cream, lotion, or gel carrier vehicle is administered as an effective treatment for all clinical stages and signs of rosacea in affected persons.
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Re: Topical Ivermectin Patent for Rosacea

Postby David Pascoe » Fri Feb 17, 2012 3:05 pm

Seems that there is more activity on the topical ivermectin front.

I am now thinking that Galderma's Large Phase III Trial of CD5024 is in fact Topical 1% Ivermectin.

Everyone involved in the trials are of course not commenting, but this page from the NHS UK seems to spill the beans for me.

http://www.ukmi.nhs.uk/applications/ndo ... rugID=5617

See Massive Rosacea Study (CD5024) Recruiting Underway for more info.
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Re: Topical Ivermectin Patent for Rosacea

Postby David Pascoe » Fri Feb 17, 2012 3:32 pm

and here we go - another patent owned by Galderma specifically mentioning Topical 1% Ivermectin and Rosacea.




Topical application of ivermectin for the treatment of dermatological conditions/afflictions


United States Patent 7,550,440

Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.

Inventors: Vincent Manetta, Gary R. Watkins
Original Assignee: Galderma S.A.
Filed: October 24, 2005

Google Patents 7550440


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Re: Topical Ivermectin Patent for Rosacea

Postby David Pascoe » Fri Feb 17, 2012 3:45 pm

So lets see what Galderma call their new product - here are some suggestions -

  • Dermamectin
  • Ivercream
  • Ivernacea
  • Avernacea
  • Avergel
  • Avercream
  • Averzole
  • Mectacream
  • Rosamectin
  • Lepimectin
  • Rosanacea
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Re: Topical Ivermectin Patent for Rosacea

Postby davem81 » Thu Mar 08, 2012 4:27 pm

Is topical Ivermectin currently available, or are we waiting to for this particular Galderma product to make it to market? (and if that is the case, can anyone hazard an educated guess as to a timescale for that?)

I am very interested in trying Ivermectin, however my Dr refused to presecribe me the oral product. In any case, I would feel happier with a topical version myself.
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Re: Topical Ivermectin Patent for Rosacea

Postby davem81 » Thu Mar 08, 2012 7:01 pm

......I see from the UK NHS link that trials will be continuing well into 2013, so I guess a launch isn't imminent? :-(

I will quiz my derm on this at my next appointment.
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