Lipid peroxidation and antioxidant protection in patients wi

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Lipid peroxidation and antioxidant protection in patients wi

Postby David Pascoe » Mon Jan 25, 2016 6:07 am

Lipid peroxidation and antioxidant protection in patients with papulopustular rosacea

Prog Health Sci 2015, Vol 5, No 2

Khvoryk D., Yarmolik A, Department of Dermatovenereology, Grodno State Medical University, Grodno, Belarus

Thus, according to the results of a comparative analysis of clinical and laboratory data of patients with papulo-pustular rosacea we can deduct the following conclusions:

  • 1. In patients with papulo-pustular rosacea prooxidant-antioxidant disbalance was found. It was manifested in the activation of lipid peroxidation and in the change of some
    parameters of antioxidant protection, the nature of which depends on the severity of the disease.
  • 2. Patients with different severity of papulopustular rosacea showed increase in primary and secondary lipid peroxidation products (DC and MDA). The concentration level of main
    components of antioxidant system was decreased. Concentration of reduced glutathione showed no change.
  • 3. The revealed disorders of prooxidant-antioxidant balance are accompanied by an increasing concentration of nitric oxide. This reflects that Larginine-NO
    system involved in the observed changes. Obviously, the NO-dependent nature of the oxidative stress is an important part of the pathogenesis of papulo-pustular rosacea for these
    patients.
  • 4. Considering that the level of liposoluble antioxidants (retinol and α-tocopherol) in the blood plasma for the patients with papulopustular rosacea is higher than that for those
    patients in the control group, we raised the question whether it is compulsory to include these antioxidants in the therapy of this disease
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