Modulators of trpa1 for the treatment of rosacea

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David Pascoe
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Modulators of trpa1 for the treatment of rosacea

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An in vitro method of screening candidate compounds for the preventive or curative treatment of rosacea is described. The method can include determining the capacity of a compound to modulate the expression or activity of the Transient Receptor Potential (TRP) cation channel, subfamily A, member 1(TRPA1), as well as the use of modulators of the expression or activity of this transcription factor for the treatment of rosacea. The method can also include in vitro diagnosis or prognosis of this pathology.

Publication number EP2654898 A1
Publication type Application
Application number EP20110805005
Publication date Oct 30, 2013
Filing date Dec 19, 2011
Inventors Jérôme AUBERT, Martin Steinhoff
Applicant Galderma Research & Development, Universitat Munster



The family of closely related cation channels, denoted Transient Receptor Potential (TRP) are known to be molecular sensors for distinct pain, temperature, chemaesthesis, and taste modalities. The first implication of TRP channels in pain and sensation was emphasized by the identification of TRPV1 at the genetic and functional level (Caterina et al; 1997).

Among the TRPs family, the transient receptor potential cation channel, subfamily A, member 1 , also known as TRPA1 , is a protein which in humans is encoded by the TRPA 1 (and in other species by the Trpal) gene.

TRPA1 , contains 14 N-terminal ankyrin repeats and is believed to function as a mechanical stress sensor. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

The invention relates to the use of TRPA1 modulators and especially antagonists, diagnostic application and monitoring application involving TRPA1 , in order to treat, diagnose and monitor rosacea in patients.
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