Bradykinin and Neurogenic Inflamation – a possible aetiology ?

Written by on December 8, 2005 in neurogenic rosacea, research, What Causes Rosacea? with 3 Comments

Seth Kendall has been a member of rosacea-support for a few years. He posted a message in March 2003 with the subject “A new explanation for rosacea”. This looked like a draft paper that was titled A NOVEL METHOD FOR INDUCING REMISSION IN ROSACEA AND A NEW HYPOTHESIS TO ACCOUNT FOR ITS AETIOLOGY.

Since then Seth has succeeded in getting his ideas from this draft paper published in a journal. Well done Seth ! Seth’s ideas about the aetiology of rosacea centre around intestinal health and bradykinin (a vasoactive nonapeptide) acting on sensory neurons which then release vasodilatory substances.

Feel free to contact me for a full copy of the article (see the About page for my email address). I hope we get to hear some more from Seth in the future.

Remission of rosacea induced by reduction of gut transit time, Clinical & Experimental Dermatology Volume 29 Issue 3 Page 297 – May 2004, Experimental dermatology, S. N. Kendall

Rosacea is a chronic disorder characterized by hypersensitivity of the facial vasculature, presenting with intense flushing eventually leading to chronic erythema and telangiectasia.

Although the precise aetiology of rosacea is not known, numerous associations with inflammatory gastrointestinal tract disorders have been reported. Furthermore, substance P-immunoreactive neurones occur in considerably greater numbers in tissue surrounding affected blood vessels suggesting involvement of neurogenic inflammation and moreover plasma kallikrein–kinin activation is consistently found in patients.

In this report, a patient without digestive tract disease is described, who experienced complete remission of rosacea symptoms following ingestion of a material intended to sweep through the digestive tract and reduce transit time below 30 h.

It is possible that intestinal bacteria are capable of plasma kallikrein–kinin activation and that flushing symptoms and the development of other characteristic features of rosacea result from frequent episodes of neurogenic inflammation caused by bradykinin-induced hypersensitization of facial afferent neurones.

The possible relevance of this hypothesis to other conditions featuring afferent hypersensitivity, such as fibromyalgia, is considered.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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3 Reader Comments

  1. Barbara says:

    David, I thought the same thing. But . . . having not much luck with all I have tried. . . I happened on a paper on the web, written by microbiology researchers.

    Then I read many more papers that, quite frankly, were above my chemistry level of comprehension . . But I was certainly able to master the conclusion !

    I guess I had an “AHA” moment. What I have been trying to do is fix the result of inflamation & bacteria that has its origin somewhere else. The mess I have with my skin now is the result of something much bigger. . . located somewhere else (gut) !

    There is quite a lot in current publication, but I found the easiest way to find it was through the biology door.

    Barbara

  2. D. Beales says:

    I read this paper with interest, but I posit a different reason for the positive effect observed at first. I tried to contact the author, but the email address listed in the paper is now defunct. If anyone knows how to contact him, please do share:

    If:

    • Rosacea is a hypersensitivity reaction to a pathogen (several are implicated)

    And:

    • Endotoxins may be the cause of the hypersensitivity

    Then:

    I posit that the initial very positive response to the intervention perhaps wasn’t due to the bran at all, but could have been due to the activated charcoal used to determine gut transit time, which may have absorbed some of the endotoxins.

    Supporting evidence:

    1: Novokreshchenov LB, Dolgushin II, Andrushenko ON, Kuchenkova MA, Chukichev AV,
    Shish VF, Imamov MZ. [Enterosorption as a method of total detoxication and
    nonspecific immune correction in acute surgical infection (a
    clinical-experimental study)]. Pediatriia. 1989;(12):62-6. Russian. PubMed PMID:
    2628913.

    2: Gardiner KR, Anderson NH, McCaigue MD, Erwin PJ, Halliday MI, Rowlands BJ.
    Adsorbents as antiendotoxin agents in experimental colitis. Gut. 1993
    Jan;34(1):51-5. PubMed PMID: 8432452; PubMed Central PMCID: PMC1374100.

    3: Ditter B, Urbaschek R, Urbaschek B. Ability of various adsorbents to bind
    endotoxins in vitro and to prevent orally induced endotoxemia in mice.
    Gastroenterology. 1983 Jun;84(6):1547-52. PubMed PMID: 6341160.

    4: Vega-Franco L, Velasco-Sánchez F, Pérez JE. [Effect of the administration of
    adsorbents on the bacterial flora of the rat intestine]. Bol Med Hosp Infant Mex.
    1982 Apr;39(4):259-63. Spanish. PubMed PMID: 7093032.

    5: Abbès S, Ben Salah-Abbès J, Abdel-Wahhab MA, Ouslati R. Immunotoxicological
    and biochemical effects of aflatoxins in rats prevented by Tunisian
    montmorillonite with reference to HSCAS. Immunopharmacol Immunotoxicol. 2010
    Sep;32(3):514-22. PubMed PMID: 20088648.

    6: Jung BG, Toan NT, Cho SJ, Ko JH, Jung YK, Lee BJ. Dietary aluminosilicate
    supplement enhances immune activity in mice and reinforces clearance of porcine
    circovirus type 2 in experimentally infected pigs. Vet Microbiol. 2010 Jul
    14;143(2-4):117-25. Epub 2009 Dec 22. PubMed PMID: 20022715.

    7: Thieu NQ, Ogle B, Pettersson H. Efficacy of bentonite clay in ameliorating
    aflatoxicosis in piglets fed aflatoxin contaminated diets. Trop Anim Health Prod.
    2008 Dec;40(8):649-56. Epub 2008 Mar 5. PubMed PMID: 18975130.

    8: Wang JS, Luo H, Billam M, Wang Z, Guan H, Tang L, Goldston T, Afriyie-Gyawu E,
    Lovett C, Griswold J, Brattin B, Taylor RJ, Huebner HJ, Phillips TD. Short-term
    safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans.
    Food Addit Contam. 2005 Mar;22(3):270-9. PubMed PMID: 16019795.

    9: Afriyie-Gyawu E, Mackie J, Dash B, Wiles M, Taylor J, Huebner H, Tang L, Guan
    H, Wang JS, Phillips T. Chronic toxicological evaluation of dietary NovaSil clay
    in Sprague-Dawley rats. Food Addit Contam. 2005 Mar;22(3):259-69. PubMed PMID:
    16019794.

    10: Ducrotte P, Dapoigny M, Bonaz B, Siproudhis L. Symptomatic efficacy of
    beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled
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    Donna L. Beales, MLIS

  3. David Pascoe says:

    Thanks for your thoughts Donna.

    I have forwarded you contact details for Seth.

    I had read the paper, but didn’t dwell on “Whole gut transit time (WGTT) was
    measured by the passage of ingested charcoal capsules”.

    An interesting thought that this could be responsible for some of the benefits that were observed.

    Good Luck,
    davidp.

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