Bionect improves Rosacea Symptoms


A recent paper in the Journal of Drugs in Dermatology suggests that Bionect may be helpful for the symptoms of rosacea.

The study found that after 4 weeks the burning or stinging and dryness of rosacea was much improved, while papules and redness were also improved.

What is Bionect?

Bionect is a prescription only cream, gel and spray that contains the active ingredient hyaluronic acid sodium salt 0.2%. The active ingredient is also styled as Low Molecular Weight Hyaluronic Acid (LMW-HA).

The publicy for Bionect say that it is `Ideal for Managing Redness, Inflammation & Discomfort Associated with Irritations of the Skin’.

Bionect Cream Ingredients

Hyaluronic acid sodium salt (Hyalastine),  polyethyleneglycol 400 monostearate, decyl ester of oleic acid,  emulsifying wax, glycerol, sorbitol solution 70%, sodium dehydroacetate, methylparaben, propylparaben, fragrance, purified water.

Article Abstract

Efficacy and tolerability of low molecular weight hyaluronic Acid sodium salt 0.2% cream in rosacea.

Schlesinger TE, Powell CR.

J Drugs Dermatol. 2013 Jun 1;12(6):664-7.

Rosacea is a chronic cutaneous disorder characterized by flushing, erythema, telangiectasia, edema, papules, and pustules.

The cause of this inflammatory disorder is unknown, but is thought to be multifaceted.

Primary treatments for rosacea are typically oral antibiotics and topical therapies.

Hyaluronic acid sodium salt cream 0.2% is a topical device containing low molecular weight hyaluronic acid (LMW-HA) that is effective in normalizing the cutaneous inflammatory response.

The objective of this study was to evaluate the efficacy and safety of hyaluronic acid sodium salt cream 0.2%.

DESIGN and SETTING: Prospective, observational, non-blinded efficacy and tolerability study in an outpatient setting.

PARTICIPANTS: Individuals 18 to 75 years of age with mild to moderate facial rosacea.

MEASUREMENTS: Outcome measures included papules, pustules, erythema, edema, telangiectasia, burning or stinging, dryness and provider global assessment (PGA), which were all measured on a five-point scale. Subjects were assessed at baseline, week 2, week 4, and week 8.

RESULTS: Final data for 14 of 15 subjects are presented. Through visual grading assessments, hyaluronic acid sodium salt cream 0.2% was shown to improve the provider global assessment by 47.5 percent from baseline to week 4.

Reductions in papules, erythema, burning or stinging, and dryness were 47, 51.7, 65, and 78.8 percent, respectively at week 4.

At week 8, the provider global assessment was improved from baseline in 78.5 percent of subjects.

CONCLUSION: Improvement was noted in measured clinical parameters with use of topical low molecular weight hyaluronic acid.

Topical low molecular weight hyaluronic acid is another option that may be considered for the treatment of rosacea in the adult population.

Compliance and tolerance were excellent. Consideration should be given to use for individuals with rosacea characterized by an erythematous and/or papular component.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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6 Reader Comments

  1. ruben says:

    I don’t believe that parabens can help our rosácea…sorry 🙁

  2. Lisamouries says:

    Why on earth did they put fragrance in there too????

  3. Sven says:

    Bionect is sold in Austria for about 7$ and it’s prescription free…. in the US it costs around 100$!

  4. Carmk says:

    I looked on their site and the gel and the spray have no fragrance in their ingredient lists, only the cream (however, they do have the parabens) I’m in Europe so I’ll check it out and will report back….

    • Carmk says:

      Verdict: no effect on my skin. It was a good non-irritating moisturizer for me and I suppose if you were using an irritating topical before and switched to using Bionect, it would improve your symptoms. But for me it didn’t result in any improvement as I had already a non-irritating skin care routine before the Bionect.

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