Azelaic acid 20% (Azelex) superior to Metrogel 0.75%

Written by on April 19, 2010 with 0 Comments

Azelex was originally created as a acne treatment.

A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea.

J Am Acad Dermatol 40:6 Pt 1 961-5, 1999 Jun

BACKGROUND: Although it is important for physicians to have sufficientclinical data on which to base treatment decisions, little comparativedata exist regarding newer treatment modalities for rosacea. OBJECTIVE: The goal of the study was to compare the efficacy and safetyof topical azelaic acid 20% cream and topical metronidazole 0.75% creamin the treatment of patients with papulopustular rosacea. Parameters ofpatient satisfaction to treatment were also assessed.

METHODS: Forty patients with the clinical manifestation of symmetricfacial rosacea were investigated in this single-center, double-blind,randomized, contralateral split-face comparison clinical trial.

RESULTS: After 15 weeks of treatment, both azelaic acid and metronidazole induced significant, albeit equal reductions in the number of inflammatory lesions (pustules and papules).

A significantly higher physician rating of global improvement was achieved with azelaic acid.

Changes in the rosacea signs and symptoms of dryness, burning, telangiectasia, and itching were equal between treatments. A reduction in erythema tended toward significance with azelaic acid at week 15.

A trace amount of stinging on application was noted with azelaic acid; however, such discomfort did not appear to concern patients because their overall impression of azelaic acid was superior to that of metronidazole.

CONCLUSION: Azelaic acid 20% cream provides an effective and safe alternative to metronidazole 0.75% cream with the added benefit of increased patient satisfaction.

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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