David Pascoe

David Pascoe started the Rosacea Support Group in October 1998.

VEGF and vasodilation

Written by on September 23, 2005 in research, VEGF with 1 Comment

An in-depth article to do with the effect of VEGF on the vasodilation and vasorelaxation of blood vessels. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature American Journal of Physiology Heart and Circulatory Physiology 286: H946-H954, 2004. Abstract: Various laboratories have reported that local subcutaneous or subdermal injection of […]

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IPL for facial blood vessels (telangiectasias)

Written by on September 20, 2005 in IPL, telangectasia with 1 Comment

This paper is discussing research that shows IPL is an effective and safe treatment for facial blood vessels. After between 1 and 4 treatments, the vast majority of patients had a 50% or better improvement in the number of blood vessels. Intense pulsed light source for treatment of facial telangiectasias, Journal of Cosmetic and Laser […]

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rambazole for acne and psoriasis

Written by on September 20, 2005 in Acne Treatments with 2 Comments

Barrier Therapeutics is developing a class of drugs called based so-called RAMBA (Retinoic Acid Metabolic Blocking Agent) molecules. Rambazole is still in development, having recently reported results in Phase 2a trials for the oral formulation for moderate to severe acne and measuring biological activity for the topical formulation. Their aim is to develop an oral […]

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Subantimicrobial Dose Doxycycline for Acne and Rosacea

Written by on September 19, 2005 in doxycycline, Oracea (40mg doxycycline), tetracyclines with 14 Comments

Some more background about subantimicrobial (sometimes referred to as SD – Subantimicrobial Dosage) doxycycline and rosacea. A dosage of around 50mg per day is enough to see a benefit in rosacea symptoms but also low enough to not affect gut flora or cause other antibiotic related side effects. SD doxycycline can also be take safely […]

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Low Dose Doxycycline as a Rosacea Treatment

Written by on September 19, 2005 in doxycycline, Oracea (40mg doxycycline) with 2 Comments

Given the recent developments in periostat, oracea and COL-3 an interesting article about the applicability of low dose doxycycline. The term SDD refers to `subantimicrobial dose doxycycline hyclate’. From US Pharmacist, Vol. No: 29:04 Posted: 4/15/04. New Applications of Doxycycline Hyclate in Medicine and Dentistry Golub and his colleagues were able to show that tetracycline […]

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