ATP Role in rosacea being studied

Written by on January 6, 2007 in What Causes Rosacea? with 0 Comments

The NRS Blog has a new entry highlighting the Dark Side of ATP. This doesn’t appear to be newly published information, but a chance to highlight the possible role of adenosine 5′-triphosphate (ATP) in the inflammatory pathways that lead to rosacea.

The key to improving therapy is to identify those inflammatory pathways involved with rosacea so they can be better controlled.”

The most evident outward signs and symptoms of inflammation are pain, heat, redness, swelling and loss of function. However, the biochemical processes that accomplish this reaction are complex, and involve dilation of blood vessels accompanied by increased blood flow, release of fluids and the movement of leukocytes — blood cells that engulf and digest bacteria and fungi and are an important part of the body’s defense system, according to Dr. Granstein.

In previous NRS-funded studies, Dr. Granstein’s team demonstrated that ultraviolet B (UVB) radiation, which is found in sunlight and causes sunburn, may increase vascular endothelial growth factor (VEGF), a regulator of blood vessel growth that may cause visible blood vessels (telangiectasia) associated with subtype 1 rosacea. In addition, they found that UVB may increase interleukin 8, which plays a role in inflammation.

Dr Granstein’s previous involvement with the NRS includes ;

Ding W, Wagner JA, Granstein RD. ATP?S enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling, Journal of Investigative Dermatology 2006;126:1017-1027 and Studies on the role of P2 receptors in rosacea.
Dr. Richard Granstein.

Read more about: What Causes Rosacea?

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About the Author: David Pascoe started the Rosacea Support Group in October 1998. .

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